How to Get Drugs Into the Brain
Drug Hunter
AUGUST 21, 2023
A) Progression of a Novartis HAT program from a screening hit to brain-penetrant leads. This program started from an HTS screen of 3M compounds, resulting in a singleton hit (Figure 17). Figure 18. B) Results from a computational model of brain-penetration correlated well with actual K p ’s across the series.
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