Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 2 However, when dosed at the MTD, ADCs display improved efficacy over small molecules in oncology trials. 3D rendering of Antibody Drug Conjugate Molecules.

Small Molecule 145

Small Molecule Drugs Clinical Pharmacology Trials 145

NIH Director's Blog: Drug Development

OCTOBER 30, 2018

Now comes word of another absolutely incredible use of cryo-EM: determining with great ease and exquisite precision the structure of the smaller organic chemical compounds, or “small molecules,” that play such key roles in biological exploration and drug development. Also analyzed were eight less-familiar small molecules.

Small Molecule 52

Small Molecule Science Drug Development Organic Chemistry 52

Drug Target Review

MAY 1, 2024

Raffaele Colombo, PhD, is Associate Director, Medicinal Chemistry at Zymeworks Inc. He has more than 14 years of experience in studying the design and synthesis of new payloads and drug-linkers for antibodies, small molecules, and nanoparticles. Dr Rich received a PhD in organic chemistry from the University of Alberta.

Drugs 69

Drugs FDA Approval Organic Chemistry Small Molecule 69

Practical Cheminformatics

OCTOBER 8, 2024

Testing Claude’s Molecule Generation Ability To test the molecule generation ability of Claude, a general-purpose LLM from Anthropic, I prompted it to generate analogs for hits from fragment screens. These fragment hits are small molecules with between 11 and 21 heavy atoms.

Fragment Screening 136

Fragment Screening Packaging Organic Chemistry Small Molecule 136

Drug Target Review

MAY 31, 2024

Coupling my desire to be a scientist with my keen sense of adventure, I moved to Alaska out of high school to begin my undergraduate studies in chemistry, applying myself to my STEM classes whilst also climbing mountains and chasing Northern Lights.

Organic Chemistry 45

Organic Chemistry Computational Chemistry Small Molecule Disease 45

Elrig

APRIL 29, 2024

There, I supported AI-enabled DD efforts in their small molecule portfolio. After graduating, Miles went on to work as a scientist on AstraZeneca’s Research and Development graduate programme, working on projects in biocatalysis, computational organic chemistry and machine learning for drug discovery.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

The Open Targets Blog

SEPTEMBER 21, 2023

After completing my PhD in organic chemistry at the University of Cambridge, I went to Canada as a Leverhulme Trust postdoctoral fellow. I then moved back to the UK to work as a process chemist at GSK, designing the manufacturing routes for small molecule drugs. I’m a chemist by training.

Organic Chemistry 83

Organic Chemistry Process Chemistry Small Molecule Science 83