Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 2 However, when dosed at the MTD, ADCs display improved efficacy over small molecules in oncology trials. 3D rendering of Antibody Drug Conjugate Molecules.

Small Molecule 145

Small Molecule Drugs Clinical Pharmacology Trials 145

The Open Targets Blog

SEPTEMBER 21, 2023

After completing my PhD in organic chemistry at the University of Cambridge, I went to Canada as a Leverhulme Trust postdoctoral fellow. I then moved back to the UK to work as a process chemist at GSK, designing the manufacturing routes for small molecule drugs. I’m a chemist by training.

Organic Chemistry 82

Organic Chemistry Process Chemistry Small Molecule Science 82

Drug Target Review

MAY 1, 2024

At Zymeworks we apply a holistic approach to optimise each of the ADC components, leveraging insights gained from clinical trials and real-world clinical experience to inform the design of novel ADCs. Raffaele Colombo, PhD, is Associate Director, Medicinal Chemistry at Zymeworks Inc.

Drugs 69

Drugs FDA Approval Organic Chemistry Small Molecule 69

Drug Target Review

MAY 31, 2024

Coupling my desire to be a scientist with my keen sense of adventure, I moved to Alaska out of high school to begin my undergraduate studies in chemistry, applying myself to my STEM classes whilst also climbing mountains and chasing Northern Lights.

Organic Chemistry 45

Organic Chemistry Computational Chemistry Small Molecule Disease 45