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New chemical process makes it easier to craft amino acids that don't exist in nature

Science Daily: Pharmacology News

Chemists describe a powerful new way to create new-to-nature, 'unnatural' amino acids, which could find use in protein-based therapies and open up novel branches of organic chemistry.

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Antibody Drug Conjugates: windows of opportunity

Drug Target Review

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. Patients and caregivers also assess the benefits offered by different therapies, weighing the progression-free survival with their off-target effects.

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Bavtavirine

New Drug Approvals

Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i. Bavtavirine is part of highly active antitiretroviral therapy (HAART) treatment regimen. Benzonitrile, 4-[[4-amino-8-[4-[(1 E )-2-cyanoethenyl]-2,6-dimethylphenyl]-2-quinazolinyl]amino]- Gilead Sciences, Inc.;

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Women in Stem with Dr Emily Leproust

Drug Target Review

I started my journey in chemistry – first as an undergraduate and then in my PhD programme at the University of Houston, where I focused on organic chemistry and nucleic acids chemistry. Often, DNA technology is used in the development of new therapies.

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Chemotherapy-free treatment for patients with blood cancer

Drug Target Review

Our vision was to give patients another option that would move away from chemotherapy-based treatments and closer to what we call a “targeted” therapy, meaning one with a more selective impact on the disease that spared normal cells as much as possible. in Organic Chemistry from the University of California, Berkeley.

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Unlocking the potential of antibody drug conjugates

Drug Target Review

T-DM1, for example, is approved in patients with HER2-positive breast cancer and residual invasive cancer following neoadjuvant therapy. As we learn what therapies are more successful within specific patient populations, treatments can be tailored to increase the likelihood of being effective.

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Welcome to new Director David Hulcoop

The Open Targets Blog

After completing my PhD in organic chemistry at the University of Cambridge, I went to Canada as a Leverhulme Trust postdoctoral fellow. Photo credit: Jeff Dowling, EMBL-EBI What is your professional background? I’m a chemist by training. What are some of the challenges of your new role?