Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. ADCs have the potential to redress the poor balance between safety and efficacy seen with traditional cancer treatment options.

Small Molecule 145

Small Molecule Drugs Clinical Pharmacology Trials 145

New Drug Approvals

MARCH 26, 2025

Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i. Bavtavirine is part of highly active antitiretroviral therapy (HAART) treatment regimen. Benzonitrile, 4-[[4-amino-8-[4-[(1 E )-2-cyanoethenyl]-2,6-dimethylphenyl]-2-quinazolinyl]amino]- Gilead Sciences, Inc.;

Organic Chemistry 62

Organic Chemistry Science Therapies Treatment 62

Drug Target Review

MAY 1, 2024

How have advancements in antibody-drug conjugates (ADCs) expanded treatment options for different types of cancer? For example, enfortumab vedotin in combination with anti-PD-1 pembrolizumab reshaped the first-line treatment of patients with previously untreated metastatic urothelial cancer, doubling OS compared to standard of care.

Drugs 69

Drugs FDA Approval Organic Chemistry Small Molecule 69

The Open Targets Blog

SEPTEMBER 21, 2023

After completing my PhD in organic chemistry at the University of Cambridge, I went to Canada as a Leverhulme Trust postdoctoral fellow. For example, there are often many potential targets you could consider developing a treatment against for a given disease; how do you choose between them? I’m a chemist by training.

Organic Chemistry 82

Organic Chemistry Process Chemistry Small Molecule Science 82

The Pharma Data

OCTOBER 23, 2020

A graduate of the Hebrew University of Jerusalem, he earned a Bachelor of Science in chemistry and physics and a Master of Science in physical organic chemistry before completing a Doctor of Philosophy in 1971. Dr. Elmaleh has contributed to more than 130 book chapters, scientific papers, and professional journal articles.

Organic Chemistry 52

Organic Chemistry Clinical Trials Science Pharmaceuticals 52

Drug Target Review

MAY 31, 2024

Coupling my desire to be a scientist with my keen sense of adventure, I moved to Alaska out of high school to begin my undergraduate studies in chemistry, applying myself to my STEM classes whilst also climbing mountains and chasing Northern Lights.

Organic Chemistry 45

Organic Chemistry Computational Chemistry Small Molecule Disease 45

PLOS: DNA Science

APRIL 17, 2025

If they are detected shortly after birth with a few drops of blood from the heel, treatment is possible. Adding these two conditions, experts say, would identify 400 to 450 babies a year whose lives could be saved, with gene therapy. That’s the case for some gene therapies. But it must begin ASAP.

Therapies 96

Therapies Bioethics DNA Organic Chemistry 96