Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. ADCs have the potential to redress the poor balance between safety and efficacy seen with traditional cancer treatment options. 3D rendering of Antibody Drug Conjugate Molecules.

Small Molecule 145

Small Molecule Drugs Clinical Pharmacology Trials 145

Drug Target Review

MAY 1, 2024

How have advancements in antibody-drug conjugates (ADCs) expanded treatment options for different types of cancer? For example, enfortumab vedotin in combination with anti-PD-1 pembrolizumab reshaped the first-line treatment of patients with previously untreated metastatic urothelial cancer, doubling OS compared to standard of care.

Drugs 69

Drugs FDA Approval Organic Chemistry Small Molecule 69

The Open Targets Blog

SEPTEMBER 21, 2023

After completing my PhD in organic chemistry at the University of Cambridge, I went to Canada as a Leverhulme Trust postdoctoral fellow. These very large teams need to stay on track to hit delivery milestones for clinical trials. Photo credit: Jeff Dowling, EMBL-EBI What is your professional background?

Organic Chemistry 82

Organic Chemistry Process Chemistry Small Molecule Science 82

The Pharma Data

OCTOBER 23, 2020

A graduate of the Hebrew University of Jerusalem, he earned a Bachelor of Science in chemistry and physics and a Master of Science in physical organic chemistry before completing a Doctor of Philosophy in 1971. and Pure Tech Health. He also remains active as the chief executive officer and chairperson of AZTherapies Inc.

Organic Chemistry 52

Organic Chemistry Clinical Trials Science Pharmaceuticals 52

Drug Hunter

AUGUST 21, 2023

Overall, only a few prodrugs for CNS disorders have even reached clinical trials , so for the most part traditional property-based drug design remains the best bet for the vast majority of programs. Figure 19: Compound 7 is highly effective in a mouse model of HAT infection, leading to cures after six days of treatment.

Drugs 206

Drugs Disease Targeted Protein Degradation Screening Hits 206

Drug Target Review

MAY 31, 2024

Coupling my desire to be a scientist with my keen sense of adventure, I moved to Alaska out of high school to begin my undergraduate studies in chemistry, applying myself to my STEM classes whilst also climbing mountains and chasing Northern Lights.

Organic Chemistry 45

Organic Chemistry Computational Chemistry Small Molecule Disease 45

PLOS: DNA Science

APRIL 17, 2025

If they are detected shortly after birth with a few drops of blood from the heel, treatment is possible. This is life-saving if no one in the family has the condition to indicate elevated risk, and especially if symptoms do not arise or are recognized for months or years, but a treatment only works if started ASAP.

Therapies 96

Therapies Bioethics DNA Organic Chemistry 96