Sygnature Discovery

SEPTEMBER 12, 2024

Protein Purification Standard chromatography methods for purification of high grade protein. In vivo biotinylation of target protein. Dedicated Membrane protein production team. Protein refolding from inclusion bodies. Low endotoxin batches.

Science 52

Science Protein Production RNA Packaging 52

Broad Institute

JANUARY 14, 2025

His lab had just developed base editing, a gene-editing approach that makes single-letter changes in DNA and can shut down protein production using strategies including installing a stop signal in the genetic code. They then administered the AAVs to mice infected with the human prion protein.

Disease 144

Disease DNA Protein Production Treatment 144

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production 40

Production FDA Therapies Biochemical Assays 40

Codon

MARCH 24, 2024

In the case of semaglutide, those cells are Saccharomyces cerevisiae— also known as Baker’s yeast — engineered to secrete a peptide precursor that is later purified, chemically modified, packaged into an injectable or tablet form, and then shipped around the world. Continuing this method may not scale.

Engineering 86

Engineering Vaccine Production RNA 86

Codon

MAY 30, 2023

The wild-type IscB protein only has 500 amino acids. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies. 3/ Cell Membrane Editor A cell is a lipid shell with lots of DNA, proteins, and RNA molecules inside. This paper is a big deal!

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

The wild-type IscB protein only has 500 amino acids. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies. 3/ Cell Membrane Editor A cell is a lipid shell with lots of DNA, proteins, and RNA molecules inside. This paper is a big deal!

DNA 52

DNA RNA Engineering Vaccine 52