Broad Institute

JANUARY 14, 2025

His lab had just developed base editing, a gene-editing approach that makes single-letter changes in DNA and can shut down protein production using strategies including installing a stop signal in the genetic code. They then administered the AAVs to mice infected with the human prion protein.

Disease 144

Disease DNA Protein Production Treatment 144

Codon

MAY 30, 2023

The wild-type IscB protein only has 500 amino acids. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies. 3/ Cell Membrane Editor A cell is a lipid shell with lots of DNA, proteins, and RNA molecules inside. This paper is a big deal!

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

The wild-type IscB protein only has 500 amino acids. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies. 3/ Cell Membrane Editor A cell is a lipid shell with lots of DNA, proteins, and RNA molecules inside. This paper is a big deal!

DNA 52

DNA RNA Engineering Vaccine 52