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I worked on a project that required development of a highly sensitive method and analysis of an active pharmaceutical ingredient to determine accurate levels of two potential genotoxic impurities. We are responsible for formulating a long-term strategy for addressing nitrosamine impurities in pharmaceuticals.
That’s the part of the process that’s analgous to the library evolution phase of Galaxy The classical approach beloved of large pharmacompanies is really a brute-force method: make as many molecules as you can to assemble the SAR.
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