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Re-Imagining Med Chem Strategies: the Tyranny of the n+1 Compound

DrugBaron

Finding small molecule drugs is much harder than finding a needle in a haystack – discovering the right arrangement of atoms to bind precisely to a protein target to elicit a particular response is a problem of vast dimensionality. Yet the situation with small molecules is even worse.

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Metabolism-Mediated Loss of Radiolabel

Metabolite Tales Blog

The paper, written by a consortium of scientists from several big pharma companies, points out that discussions around multi labelling are happening with more frequency due to the increase in larger molecular weight small molecules being developed. Eur J Drug Metab Pharmacokinet 48 , 411–425 (2023). Drug Metab.

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BioSpace Global Roundup, Oct. 15

The Pharma Data

Talking Medicine uses advanced AI to provide pharmaceutical companies with real-time data intelligence. has expanded its product portfolio to include Blueprint, a self-service, scientific visualization and analytics application for small molecule discovery. Dolmatics – U.K.-based based Dotmatics Ltd.