Molecule Blog

MARCH 17, 2023

The university then licenses the IP to an existing pharmaceutical company or a biotech startup, which takes on Investigational New Drug (IND) enabling studies. Funding typically comes from a mix of government agencies, venture capitalists (VCs), and pharmaceutical companies.

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The Pharma Data

NOVEMBER 4, 2020

(Nasdaq: CNTG), a commercial-stage company focused on rare diseases that transforms real-world clinical and genetic data into actionable information for patients, physicians, and pharmaceutical companies, announced today the opening of its walk-in COVID-19 testing facility at the newly opened Berlin Brandenburg Airport (BER).

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Laboratories Pharmaceutical Companies Disease Pharmaceuticals 40

Metabolite Tales Blog

JANUARY 26, 2023

Table 1 – Small molecule drugs approved by the FDA in 2022 and the major reported route of biotransformation *Note: 17 small molecule drugs as classified in C&EN ( [link] i.e. excluding antibody-drug conjugates, antibodies, proteins, radioligands and small interfering RNA).

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Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

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The Pharma Data

JANUARY 21, 2021

21, 2021 /PRNewswire/ — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 Two percent of patients in both treatment arms had an HIV-1 RNA count ?50

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FDA Approval Treatment RNA FDA 52

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

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Drug Target Review

MARCH 6, 2024

LSD1 acts as an epigenetic modifier but also forms a variety of complexes with transcription factors, promoters, activators, corepressors and non-coding RNA. What are the specific mechanisms through which LSD1 inhibition leads to tumour cell death?

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The Pharma Data

MARCH 4, 2021

Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) (“Takeda”) and Ovid Therapeutics Inc. About Takeda Pharmaceutical Company Limited. A replay of the call will be available on the Ovid Therapeutics website following the completion of the call and will be archived for 30 days.

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Treatment Clinical Trials Pharmaceutical Companies Trials 52

The Pharma Data

OCTOBER 27, 2020

These include blocking viral binding to the human ACE2 receptor (Receptor Binder Domain or RBD), the primary docking mechanism to host cells, as well as allosteric inhibition or “molecular handcuffing”, of the spike protein, preventing the conformational change it undergoes prior to injection of viral RNA into the human cell.

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DrugBank

NOVEMBER 25, 2024

Products like Onpattro® highlight how nanoparticles can safely and effectively deliver RNA-based therapies, with the potential to revolutionize treatments for a range of diseases. Similarly, nanomedicine is expanding its reach beyond oncology, addressing solubility, stability, and targeted delivery issues.

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Drugs Therapies Pharmaceuticals Vaccine 52

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. And given that RNA and lipid nanoparticle synthesis is highly efficient compared to typical bioproduction, it’s likely that the company could have scaled to billions of doses.

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Engineering Vaccine Production RNA 86

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

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DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. It uses single-molecule RNA fluorescence to measure mRNAs and fluorescent reporters to measure the proteins. RNA-guided nucleases, called HERMES, are common across eukaryotes and the viruses that infect them. Paper by Sha G. in Nature.

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DNA Therapies Engineering Clinical Trials 52

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). The single remaining pharmaceutical company was thus nationalized, data was collected, and the trained model deployed in full force. First, the models targeted the oceans.

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Engineering Virus DNA Therapies 144

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. A drug called thalidomide, initially made by a West German pharmaceutical company called Chemie Grünenthal, was manufactured and given to patients as a mixture containing both enantiomers.

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RNA DNA Vaccine Virus 104

The Pharma Data

NOVEMBER 29, 2021

About Eisai Eisai is a leading global exploration and development- grounded pharmaceutical company headquartered in Japan, with roughly workers worldwide. Eisai aspires to discover innovative new medicines with new targets and mechanisms of action from these Ricchi, with the end of contributing to the cure of cancers.

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Treatment RNA Pharmaceutical Companies Vaccine 52

The Pharma Data

SEPTEMBER 8, 2020

About the Janssen Pharmaceutical Companies of. We’re the Pharmaceutical Companies of. is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Forward-Looking Statement of the Janssen Pharmaceutical Companies of. Learn more at Learn more at.

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Science Vaccine Clinical Trials Pharmaceutical Companies 52

The Pharma Data

SEPTEMBER 8, 2020

About the Janssen Pharmaceutical Companies of Johnson & Johnson At Janssen, we’re creating a future where disease is a thing of the past. About Moderna Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Learn more at Learn more at www.jnj.com.

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Drug Target Review

NOVEMBER 27, 2024

11 Pharmaceutical companies are increasingly outsourcing due to resource and capacity constraints, the need for specialised expertise, and the flexibility outsourcing offers in project management. The global biomarker discovery outsourcing service market was estimated at $2.7 billion in 2016 and continues to grow.

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Codon

NOVEMBER 3, 2024

Based on these results, Waksman asked the pharmaceutical company Merck to mass-produce streptomycin for further tests that could provide clearer evidence of its efficacy and safety. The drug didn’t cure the animals at such low doses, but their health did improve, hinting at the drug’s efficacy.

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The Pharma Data

DECEMBER 23, 2020

So far, only two pharmaceutical companies — Pfizer and Moderna — have won emergency approval for their COVID-19 vaccines. The deal calls for the government to invoke the Defense Production Act to give the company better access to roughly nine specialized products it needs to make the vaccine.

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The Pharma Data

DECEMBER 28, 2020

So far, only two pharmaceutical companies — Pfizer and Moderna — have won emergency approval for their COVID-19 vaccines. The deal calls for the government to invoke the Defense Production Act to give the company better access to roughly nine specialized products it needs to make the vaccine.

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Vaccine Government Virus Medical Schools 52

Codon

FEBRUARY 23, 2025

In 2024, the pharmaceutical company Gilead announced that a single injection of lenacapavir protected 96 to 100 percent of recipients from HIV for up to six months. Since zidovudine failed to interfere with DNA-to-DNA replication, Ostertag wondered if it could block RNA-to-DNA replication instead.

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