Drug Patent Watch

DECEMBER 13, 2023

The small molecule drug covered by this patent is AMITIZA. Takeda Pharmaceutical Company… The post New patent lawsuit: Walgreen CO v. Takeda Pharmaceutical Company Limited – Drug patent: 7,795,312 appeared first on DrugPatentWatch - Make Better Decisions. See more details at Walgreen CO v.

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Pharmaceutical Companies Small Molecule Pharmaceuticals Drugs 45

Drug Patent Watch

DECEMBER 13, 2023

The small molecule drug covered by this patent is AMITIZA. Takeda Pharmaceutical Company… The post New patent lawsuit: Walgreen CO v. Takeda Pharmaceutical Company Limited – Drug patent: 8,779,187 appeared first on DrugPatentWatch - Make Better Decisions. See more details at Walgreen CO v.

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Drug Target Review

JULY 6, 2023

1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecule to degrader a protein of interest in the early 2000s.

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Targeted Protein Degradation Small Molecule Clinical Trials Science 98

The Pharma Data

JANUARY 19, 2021

Dr. Clark Cheng, Chief Medical Officer and Executive Director of Aptorum Group, commented, “The clearance of our CTA application for ALS-4 drug represents a significant milestone for the company and one of a number of targeted strategic goals for 2021. About ALS-4. About Aptorum Group.

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The Pharma Data

NOVEMBER 19, 2020

To date, the Company has applied its world-leading structure-based drug design (SBDD) capabilities and cutting-edge technologies to precision-design new inhibitors of the SARS-CoV-2 M pro protease, which plays a crucial role in viral replication 1-4.

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Small Molecule Structure Based Drug Design (SBDD) Molecular Biology International 40

The Pharma Data

NOVEMBER 30, 2020

Biohaven acquires exclusive global rights to a portfolio of novel, small-molecule CGRP antagonists. The lead candidate, HTL0022562, has advanced through preclinical development demonstrating promising and differentiated properties for further investigation in human trials. Vlad Coric , M.D.,

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Conversations in Drug Development Trends

APRIL 4, 2024

Stability Tests: For small molecule, only -20°C stability testing is required, while large molecule need both -20°C and -70°C tests if samples are intended for storage at these temperatures. Quality Control Batches : These batches are utilized to ensure the assay’s accuracy when measuring various study samples.

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Drug Target Review

JUNE 19, 2024

Also, many companies never reached the point where they received validation from big pharmaceutical companies. Transplanting cells could prove to be more beneficial than treating a particular condition with a small molecule or an antibody, and that really speaks to the power of cell therapy.

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Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

DrugBank

MAY 22, 2024

In the dynamic world of drug discovery, the notion of "undruggable" targets presents both a significant challenge and an intriguing frontier for researchers and pharmaceutical companies. Strategies to Tackle PPIs Despite these challenges, some wins in targeting PPIs with small molecules have emerged.

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Small Molecule RNA DNA Pharmaceutical Companies 66

The Pharma Data

NOVEMBER 29, 2020

(Headquarters: Cambridge, UK, “Wren”) today announced that the companies have entered into an exclusive research collaboration agreement aiming to advance the discovery of novel small molecules that target ?-synuclein is a leading global research and development-based pharmaceutical company headquartered in Japan.

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Small Molecule Research Pharmaceutical Companies Drugs 52

Drug Target Review

APRIL 16, 2024

Peptides are relatively small molecules compared to mAbs, making them easier and less costly to produce and modulate. Nevertheless, mAbs are often considered superior to peptides or small molecules in RLT if their long accumulation and excretion profile could be accelerated.

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Small Molecule Therapies Treatment Pharmaceutical Companies 59

KIF1A

JULY 1, 2023

Making drug repositioning a part of therapeutic development is a complicated endeavor relying on interactions between regulatory bodies, pharmaceutical companies, rare disease researchers, and patients. It requires a deep look at former products that ended at various stages of research and development.

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Small Molecule FDA Approval Disease Pharmaceutical Companies 98

The Pharma Data

AUGUST 7, 2021

(Vividion), a US-headquartered biopharmaceutical company utilizing novel discovery technologies to unlock high value, traditionally undruggable targets with precision therapeutics. Vividion’s platform is able to produce a variety of small molecule therapies across indications, with initial focus on targets relevant to oncology and immunology.

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Small Molecule Drugs Therapies Disease 52

The Pharma Data

SEPTEMBER 22, 2020

We are delighted to close this deal with Roche, an outstanding pharmaceutical company with a broad commitment to multiple indications,” said Matt Cooper, chief executive officer of Inflazome. Roche has plans to further develop Inflazome’s products across a wide range of indications with high unmet medical need.

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Pharma Companies Small Molecule Pharmaceutical Companies Disease 52

Drug Target Review

JULY 18, 2023

With support from pharmaceutical companies, ultimately, the answer to this question should be yes. Pharmaceutical companies are an absolutely pivotal part of the life sciences industry and ecosystem. She also co-founded and sits on the Board of Directors of Sevenless Therapeutics, a small molecule pain company.

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Drug Development Drugs Clinical Development Pharmaceutical Companies 98

The Pharma Data

APRIL 28, 2021

OSAKA, Japan, April 28, 2021 – Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) (“Takeda”) today announced that it was awarded by the International Society for Pharmaceutical Engineering (ISPE) for the 2021 Facility Of the Year Awards (FOYA) in two categories. About Takeda Pharmaceutical Company Limited.

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Packaging Small Molecule Pharmaceutical Companies Pharmaceuticals 52

DrugBank

OCTOBER 17, 2024

By harnessing the vast amounts of data generated throughout the development pipeline, pharmaceutical companies can accelerate the discovery of novel therapies, optimize clinical trial design, enhance drug safety monitoring, and deliver personalized medicine, ultimately improving patient outcomes and transforming the future of healthcare.

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Practical Cheminformatics

JANUARY 8, 2024

While large pharmaceutical companies have data on thousands or even millions of compounds, this data is rarely shared due to intellectual property concerns. Data from 21 million molecules and more than 40,000 assays was securely combined into a multitask model. For classification models, the participants reported a median 2.5-7.5%

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The Pharma Data

AUGUST 18, 2020

In this role, we are helping bring together Europe’s best and brightest scientific minds from 37 renowned academic institutions, research organizations and pharmaceutical companies, together with partners from the United States and China. Small molecule discovery. Virus-neutralizing antibody discovery. Source link.

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Treatment Pharmaceutical Companies Research Small Molecule 52

The Pharma Data

NOVEMBER 23, 2020

At Ultimovacs, he will lead all business and corporate development efforts and continue to maintain and foster connections with leading biotechnology and pharmaceutical companies. “In Berkien will join Ultimovacs from his current position at Amgen as Director Global Business Development.

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Clinical Trials Small Molecule Pharmaceutical Companies Licensing 52

DrugBank

AUGUST 15, 2024

To effectively navigate this ecosystem and expedite the development of new therapies, collaboration between the pharmaceutical industry and academia is proving increasingly vital. This includes funding large-scale clinical trials and establishing robust manufacturing/distribution networks.

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Drug Target Review

JULY 7, 2023

It normally binds to and recycles internalised immunoglobin G (IgG) antibodies, which are important for fighting infections, as well as albumin, which helps move many small molecules through the blood. The result of this ‘recycling’ is that FcRn increases levels of IgG by preventing the body from breaking it down.

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The Pharma Data

APRIL 6, 2021

The product is developed jointly by Bayer and Orion Corporation, a globally operating Finnish pharmaceutical company. o Abstract 1470; April 10, 8:30am EDT. • Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1. About Oncology at Bayer.

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Research Small Molecule Treatment Clinical Trials 52

The Pharma Data

DECEMBER 21, 2020

Program focused on identifying small molecules that target a GPCR for degradation as potential therapeutic agents for gastrointestinal disorders. The principle of TPD is to use small molecules to commit the target protein into the E3 ligase-mediated degradation pathway thereby eliminating or reducing its activity.

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Targeted Protein Degradation Small Molecule Structure Based Drug Design (SBDD) Drugs 40

The Pharma Data

OCTOBER 27, 2020

APRINOIA Therapeutics is currently advancing a pipeline featuring diagnostic and therapeutic programs, collectively targeting brain disorders associated with abnormal accumulation of pathological proteins, including tau and alpha-synuclein, from its proprietary small molecule and antibody discovery platforms.

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Drug Target Review

APRIL 19, 2024

The discovery of the folding intermediate states to target has been enabled by our proprietary computational platform, and the development of small molecule folding interfering degraders is now accelerated by a proprietary AI platform. We are now in the preclinical stage of developing a proprietary drug pipeline.

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New Drug Approvals

SEPTEMBER 10, 2024

g/mol 1929519-13-0 NBI-1065846 or TAK-041 Phase 2 (S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide Zelatriazin ( NBI-1065846 or TAK-041 ) is a small-molecule agonist of GPR139. Zelatriazin, C 18 H 15 F 3 N 4 O 3 , 392.3 X H NMR (500 MHz, DMSO-i¾) δ ppm 1.40 (d, J=6.8

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Clinical Pharmacology Small Molecule Pharmacokinetics Pharmaceutical Companies 62

Drug Target Review

MAY 23, 2023

Algae – an overlooked resource for new therapies It is only in recent years that algae research has expanded beyond their potential for producing biodiesel, to also consider them as a bio-resource, not only for novel prebiotics but also for compounds with unique structures and pharmaceutically relevant bioactivities.

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The Pharma Data

MAY 2, 2023

The government of our state places a high priority on creating a favourable environment to enable pharmaceutical companies like Boehringer Ingelheim to keep developing and manufacturing locally. Biopharmaceuticals and small molecules each account for approximately half of the company’s research pipeline.

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Small Molecule Clinical Trials Pharmaceuticals Pharmaceutical Companies 40

The Pharma Data

DECEMBER 13, 2020

As a pharmaceutical company with strong R&D and manufacturing capability, Langhua is primarily engaged in CDMO business, working on the production of raw materials, intermediates and APIs for small molecule drugs. Jianguo Ma , introduced Langhua’s current business overview and future development plans.

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The Pharma Data

JULY 15, 2021

Vincent’s Institute of Medical Research (SVI)’s multi-year research collaboration with Janssen Pharmaceuticals, Inc. Vincent’s Institute of Medical Research (SVI)’s multi-year research collaboration with Janssen Pharmaceuticals, Inc.

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The Pharma Data

AUGUST 21, 2020

It’s a coalition of globally renowned academic institutions, pharmaceutical companies and nonprofit research organizations. Novartis has agreed to contribute a carefully curated library of about 1300 small molecules with antiviral activity to the CARE project. CARE stands for Corona Accelerated R&D in Europe.

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The Pharma Data

OCTOBER 19, 2020

a multinational pharmaceutical company, where he was the head of Research & Development and responsible for the R&D strategy (France). At Aduro, he was responsible for all manufacturing and supply chain activities for the company’s biologics and small molecules and managed a transatlantic team.

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Trials Small Molecule Cell Biology Clinical Trials 40

The Pharma Data

APRIL 7, 2023

This is a fine balance to achieve – if the compounds are too large, they may not pass through the cell membrane, and their bioavailability would be affected; if they are too small, they would not retain high specificity to the target protein (or proteins).

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Small Molecule Drugs Pharmaceutical Companies Research 40

The Pharma Data

MARCH 4, 2021

Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) (“Takeda”) and Ovid Therapeutics Inc. About Takeda Pharmaceutical Company Limited. A replay of the call will be available on the Ovid Therapeutics website following the completion of the call and will be archived for 30 days. selective GABA A receptor agonist.

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Treatment Clinical Trials Pharmaceutical Companies Trials 52

The Pharma Data

OCTOBER 14, 2020

AOP Orphan – AOP Orphan Pharmaceuticals took over the Viennese pharmaceutical company Amomed and the Luxembourgish health-tech company SciPharm. Talking Medicine uses advanced AI to provide pharmaceutical companies with real-time data intelligence. Growth Programme. Dolmatics – U.K.-based

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Clinical Trials Trials Pharmaceuticals Therapies 52

The Pharma Data

DECEMBER 15, 2020

SH) was founded in Shenzhen on 2001, specializing in the research and development of novel small molecule drugs. Shenzhen Chipscreen Biosciences Co., Chipscreen Biosciences, Stock Symbol: 688321.SH)

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