Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

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Drug Discovery World

DECEMBER 12, 2023

Exonate has now regained full rights to its complete portfolio of ophthalmology assets from Janssen Pharmaceuticals EXN407 is reportedly well placed to be the first topical treatment for retinal vascular diseases, including diabetic retinopathy and diabetic macular oedema. EXN407 is a small molecule inhibitor of splice factor kinase SRPK1.

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The Pharma Data

JANUARY 19, 2021

Precision medicine developer Kura Oncology is positioned to make a meaningful difference in the treatment of cancer in the next few years with its two, wholly-owned, small molecule compounds. Photo courtesy of Kura. It’s in the spotlight, the data is stunning, and it has a lot of promise,” Troy Wilson, Ph.D., CEO, told BioSpace.

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Drug Discovery World

OCTOBER 20, 2022

They are called “ The potential of small molecules and biologics for new therapeutics ”, “ AE reporting turnarounds and the translation issue ” and “ Why we are on the cusp of a golden age of medicine ”. Dr Seth Lederman is a physician-scientist, entrepreneur, and CEO of Tonix Pharmaceuticals.

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Drug Discovery World

AUGUST 29, 2024

Now, with HT-SPR, researchers have the ability to screen entire antibody and small molecule libraries, along with characterising epitopes, so there is way more data available at the earliest stages of drug discovery than ever before.” The post Tech Focus: How is HTS accelerating early-stage drug discovery?

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Drug Discovery Today

APRIL 20, 2023

Global integrated drug discovery company, Sygnature Discovery and global healthcare group Daewoong Pharmaceutical, have entered into a research collaboration agreement to accelerate the discovery of a novel small molecule to target autoimmune disease.

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Drug Discovery World

NOVEMBER 1, 2022

Researchers at the University of Illinois Urbana-Champaign and collaborators in Poland and Canada doubled the average yield of a special, hard-to-optimise type of reaction linking carbon atoms together in pharmaceutically important molecules.

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Drug Discovery World

OCTOBER 20, 2022

They are called “ The potential of small molecules and biologics for new therapeutics ”, “ AE reporting turnarounds and the translation issue ” and “ Why we are on the cusp of a golden age of medicine ”. Dr Seth Lederman is a physician-scientist, entrepreneur, and CEO of Tonix Pharmaceuticals.

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Drug Discovery World

AUGUST 29, 2024

Yunovia (a subsidiary of Ildong Pharmaceutical Group) has received permission from the Ministry of Food and Drug Safety (MFDS) of Korea to begin a Phase I study for its small molecule glucagon-like peptide-1 (GLP-1) agonist for obesity and diabetes.

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Drug Discovery World

MAY 31, 2024

Plant-based drug reduces symptoms in functional diarrhoea patients This World Digestive Health Day, Napo Pharmaceuticals has announced positive results of a third-party, investigator-initiated study of crofelemer, Napo’s novel plant-based prescription drug.

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Drug Discovery World

MARCH 12, 2024

These confounding factors limit the opportunity for big pharma, especially considering the poor access to the complex small molecule pharmacophores known to have a link to the target disease and from which drug discovery programmes can be rolled out. RA: Could you discuss the concept of new-to-nature?

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Drug Patent Watch

DECEMBER 13, 2023

The small molecule drug covered by this patent is AMITIZA. Takeda Pharmaceutical Company… The post New patent lawsuit: Walgreen CO v. Takeda Pharmaceutical Company Limited – Drug patent: 7,795,312 appeared first on DrugPatentWatch - Make Better Decisions. A new lawsuit citing drug patent 7,795,312 has been filed.

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Drug Patent Watch

DECEMBER 13, 2023

The small molecule drug covered by this patent is AMITIZA. Takeda Pharmaceutical Company… The post New patent lawsuit: Walgreen CO v. Takeda Pharmaceutical Company Limited – Drug patent: 8,779,187 appeared first on DrugPatentWatch - Make Better Decisions. A new lawsuit citing drug patent 8,779,187 has been filed.

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Drug Discovery World

FEBRUARY 12, 2024

Cameron Ross, SVP, Generative AI, Elsevier “AI has the potential to dramatically shorten one of the most costly areas of early drug development – small molecule discovery. We’re already seeing biotechs making breakthroughs with AI in this area, with more than 150 small molecule drugs discovered and 15 already in clinical trials.

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Drug Hunter

JUNE 11, 2023

Small molecule drugs make up most of the drugs we take conveniently as pills, including painkillers like ibuprofen (Advil), antibiotics like penicillin and amoxicillin, or cholesterol-lowering drugs like atorvastatin (Lipitor). The small molecules drugs of today look nothing like the molecules of the 1970s.

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Drug Discovery World

FEBRUARY 5, 2024

Opening keynote Following a change to the schedule, Juliet Williams of Kymera Therapeutics launched the event with a popular keynote talk ‘Solving Big Problems with Small Molecule Degraders’.

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Drug Discovery World

DECEMBER 9, 2022

The event is focused on discovery and optimisation challenges of small molecule drug candidates, with various content tracks running concurrently across the three days. . Drug Discovery Chemistry is a conference for medicinal and biophysical chemists working in pharma, biotech, and academia.

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Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 2 However, when dosed at the MTD, ADCs display improved efficacy over small molecules in oncology trials. 3D rendering of Antibody Drug Conjugate Molecules.

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Drug Discovery World

JUNE 1, 2023

The independent Data Monitoring Committee (DMC) has recommended the continuation of Algiax Pharmaceuticals’ Phase IIa study with lead candidate AP-325 in chronic neuropathic pain. AP-325 is a small molecule drug candidate that binds and modulates the GABAA receptor, reducing the excitability of the respective neurons.

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Drug Discovery World

JANUARY 12, 2023

X-Chem provides services to pharmaceutical and biotech companies for screening, hit validation and lead optimisation. Its DEL platform is designed to discover novel small molecule leads against challenging, high-value therapeutic targets. .

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The Pharma Data

NOVEMBER 19, 2020

The Company is also aiming to leverage the highly conserved structure of the SARS-CoV-2 M pro protease as a basis for the design of novel oral small molecules against predicted future variants of SARS-CoV-2 and other related human viruses.

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Drug Discovery World

JANUARY 17, 2023

The study, led by OSU Associate Professor of Pharmaceutical Sciences Gaurav Sahay, Oregon State doctoral student Marco Herrera-Barrera, and Oregon Health & Science University Assistant Professor of Ophthalmology Renee Ryals, was published in Science Advances. . “We Limitations of AAV gene therapy . Sahay and Ryals have received a $3.2

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DrugBank

MAY 15, 2024

One approach is to look beyond the traditional drug molecule. Researchers are experimenting with biologics—larger biological molecules that can do things small molecules can't, like targeting larger, more complex structures on cell surfaces or even inside cells.

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The Pharma Data

NOVEMBER 30, 2020

Biohaven acquires exclusive global rights to a portfolio of novel, small-molecule CGRP antagonists. NURTEC is a trademark of Biohaven Pharmaceutical Ireland DAC. Sosei Heptares will receive an upfront payment of US$10 million, plus downstream payments of up to US$370 million, plus tiered royalties.

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Drug Target Review

JULY 6, 2023

1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecule to degrader a protein of interest in the early 2000s.

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Drug Discovery World

FEBRUARY 19, 2024

This move indicates that, despite the financial downturn, there are still acquisitions and funding releases, particularly in the gene therapy space and for those developing promising small molecule or biologic products that are potentially transformative for patients and where a relatively short timeline to market is likely (e.g.

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Drug Discovery World

SEPTEMBER 29, 2022

In this listicle, SAMDITech outlines the benefits of outsourcing models in the pharmaceutical industry, looking past perceived costs to the value outsourcing can bring. . protein-protein or small molecule-target interactions). Compound libraries: Small molecules, large roles.

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Drug Discovery World

DECEMBER 26, 2023

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe.

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Drug Discovery World

FEBRUARY 13, 2024

The attention on this tool brought further waves of interest into how AI could be deployed across the pharmaceutical and drug discovery sectors. But is AI the answer to the industry’s development challenges? Progress isn’t stagnant though.

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Broad Institute

OCTOBER 4, 2023

By Allessandra DiCorato October 4, 2023 Credit: AbbVie The new small molecule inhibitor (green) sits inside the PTPN2 protein, where acidic sites are marked in red and basic sites are marked in blue. A new small-molecule drug candidate being tested in an early-stage clinical trial aims to improve patient responses to immunotherapy.

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Drug Discovery World

OCTOBER 21, 2022

Enanta Pharmaceuticals, a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, has dosed the first subject in its Phase I clinical trial of EDP-323, a novel, oral L-protein inhibitor in development for the treatment of respiratory syncytial virus (RSV). .

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Drug Discovery World

FEBRUARY 22, 2023

Gary Connors , Partner at business consulting company Oliver Wight EAME looks at some of the most important factors that will affect the pharmaceutical industry going forward. We advise all our clients to make assumptions and think about scenarios that could affect their business at least five years in advance.

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FDA Law Blog: Biosimilars

JULY 24, 2024

Each fall, leading pharmaceutical patent litigators for brand-name and generic drug companies gather at the Paragraph IV Disputes Master Symposium in Chicago to receive up-to-the-minute information on the latest developments affecting Hatch-Waxman litigation and participate in significant peer-to-peer networking opportunities.

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Drug Discovery World

FEBRUARY 16, 2023

Dr Ouvry will be responsible for managing internal and external resources to advance the company’s pre-clinical pipeline of small molecule assets which inhibit the mitochondrial permeability transition pore (mPTP) through a novel MOA. Wang Zilong, H.E.L Group: H.E.L

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Drug Discovery World

APRIL 10, 2023

India is traditionally known as ‘the pharmacy of the world’ due to its huge pharmaceuticals manufacturing capacity and high quantity of exports, particularly generic medicines and vaccines. It is emerging markets like India that analysts expect to spearhead the global growth of the pharmaceutical sector 1.

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Zobio

MARCH 12, 2024

This event serves as a premier gathering for medicinal chemists in the pharmaceutical and biotech industries, focusing on the challenges and advancements in small molecule drug discovery and optimization. This year Johan Veerman presented Site.

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Zobio

MARCH 12, 2024

This event serves as a premier gathering for medicinal chemists in the pharmaceutical and biotech industries, focusing on the challenges and advancements in small molecule drug discovery and optimization. This year Johan Veerman presented Site.

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