BioPharma Drive: Drug Pricing

SEPTEMBER 20, 2023

Targeted protein degradation has emerged as one of the more competitive areas of pharmaceutical research in recent years as scientists develop new ways to reach difficult-to-drug targets.

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Targeted Protein Degradation Drugs Pharmaceuticals Research 280

Drug Target Review

JULY 6, 2023

Unlike traditional drug discovery, which focuses on inhibiting or activating proteins, TPD offers a more precise and efficient way to alter cellular pathways. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecule to degrader a protein of interest in the early 2000s. How does TPD work? Nature News.

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Targeted Protein Degradation Small Molecule Clinical Trials Science 98

The Pharma Data

DECEMBER 16, 2020

Evotec and Bristol Myers Squibb (the successor in interest to Celgene ) initiated their long-term strategic drug discovery and development partnership in the field of targeted protein degradation in 2018 with the goal to identify novel drug targets.

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Targeted Protein Degradation Bioinformatics Disease Drugs 40

Sygnature Discovery

SEPTEMBER 25, 2023

Sygnature Discovery identifies potent SHP2 degrader compounds using its proprietary targeted protein degrader platform, CHARMED, in collaboration with Japanese specialty chemical company, UBE Corporation.

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Targeted Protein Degradation Small Molecule Science Disease 52

The Pharma Data

DECEMBER 21, 2020

Targeted protein degradation (TPD) is an approach whereby the body’s natural process for degrading proteins is diverted using small molecule drugs to eliminate disease-causing proteins. . TOKYO and CAMBRIDGE, England , Dec. No further financial details are disclosed.

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Targeted Protein Degradation Small Molecule Structure Based Drug Design (SBDD) Drugs 40

Drug Target Review

OCTOBER 4, 2023

Before joining Abzena in 2015, he held multiple positions of increasing responsibility in Biotech including Head of Cellular Immunology at Cantab Pharmaceuticals, Director of Programs at Piramed Pharma, and R&D Director at Immune Targeting systems. 102 , 1–6 (2016). link] Park H-K, et al.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

Drug Target Review

JULY 5, 2024

Pharmaceutics. Pharmaceutics. Her research interest is in the neuroscience and oncology areas using both traditional and targeted protein degradation approaches. Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output. Nature Neuroscience. 22:669-679 (2019). 12(3) (2023).

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Drugs Targeted Protein Degradation Disease FDA Approval 64