Pharmacogenetics, Pharmacokinetics and Trials

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Pharmacogenetics

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Central Nervous System Distributional Kinetics of Selected Histone Deacetylase Inhibitors [Metabolism, Transport, and Pharmacogenetics]

ASPET

APRIL 26, 2024

In this study, we investigated the systemic pharmacokinetics and subsequent CNS distribution of two potent HDACIs, vorinostat and quisinostat, in the murine model. A knowledge of CNS exposure (K p,uu ), time to peak, and duration can inform dosing strategies in preclinical and clinical trials in selected CNS tumors.

Pharmacogenetics

Pharmacogenetics Pharmacokinetics Clinical Trials Trials

Inside The Altascientist: Understanding Drug Interaction Factors for Safer, More Effective Therapies

Alta Sciences

DECEMBER 31, 2024

The issue also features a drug-drug interaction case study, in which the effects of two doses of a sponsors investigational product on the pharmacokinetics of multiple oral doses of clopidogrel, and a single dose of warfarin in healthy adult subjects were evaluated. The Altascientist, Issue 7, pg. The Altascientist, Issue 7, pg.

Therapies

Therapies Pharmacokinetics Pharmacogenetics Clinical Trials

Drug Discovery Digest

Central Nervous System Distributional Kinetics of Selected Histone Deacetylase Inhibitors [Metabolism, Transport, and Pharmacogenetics]

Inside The Altascientist: Understanding Drug Interaction Factors for Safer, More Effective Therapies

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