Factors influencing the Central Nervous System (CNS) distribution of the ATR inhibitor elimusertib (BAY1895344): Implications for the treatment of CNS tumors [Metabolism, Transport, and Pharmacogenetics]
ASPET
SEPTEMBER 16, 2024
Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemo-sensitizers.
100 
Let's personalize your content