Broad Institute

JULY 17, 2024

Researchers at the Broad Institute of MIT and Harvard have developed AI models that can screen the potential biological effects of drugs before they ever enter a living organism. Drug developers also assess pharmacokinetic effects, or how an organism absorbs, distributes, metabolizes, and clears a drug. A fourth is in the works.

Pharmacokinetics 124

Pharmacokinetics Molecular Biology Drugs FDA 124

Alta Sciences

JANUARY 31, 2024

Pharmacokinetics, Pharmacodynamics and Toxicokinetics Demystified pmjackson Wed, 01/31/2024 - 14:55 Understanding the effects of a drug, and how it interacts with the body, and vice versa, is critical to ensure it is safe for human use. This is where pharmacokinetic (PK), pharmacodynamic (PD) , and toxicokinetic (TK) analyses step in.

Pharmacokinetics 52

Pharmacokinetics Clinical Trials Drug Development Trials 52

PPD

JULY 29, 2024

The benefits of utilizing AI in clinical research Patient recruitment and diversity AI is increasingly being utilized in the recruitment process for clinical trials , aiming to connect individuals with potential benefits from investigational treatments.

Clinical Research 98

Clinical Research Clinical Trials Research Trials 98

Alta Sciences

AUGUST 22, 2023

34 — Toxicokinetics, Pharmacokinetics, and Pharmacodynamics mecabana Tue, 08/22/2023 - 17:31 Publication the-altascientist-issue-34-toxicokinetics-pharmacokinetics-and-pharmacodynamics.pdf URL [link] Weight 1 Tags Research Support

Pharmacokinetics 40

Pharmacokinetics Research 40

Drug Target Review

APRIL 7, 2025

As pharmacological indicators, biomarkers overcome the static nature of traditional in vitro cellular studies by providing more dynamic models of pharmacokinetic processes that reflect active biological mechanisms. Trial design and statistical methods are also key to determining the utility and validity of biomarkers.

Clinical Development 59

Clinical Development Clinical Trials Clinical Pharmacology Trials 59

Conversations in Drug Development Trends

JANUARY 21, 2025

Jayaprakash Kotha, MBBS, PhD, ASCP (SH), Vice President, Bioanalytical Laboratory Satish Kumar, MBB, Head of Process Improvement Continuous Innovation is a Cornerstone of Bioanalysis Approximately 80% of drugs that begin the research process fail to reach approval. What is one contributing factor that sets the 20% that do apart from the rest?

Clinical Trials 78

Clinical Trials Laboratories Trials Drug Development 78

Chemical Biology and Drug Design

AUGUST 18, 2024

The present work systematically gives a comprehensive review in current developments of benzimidazole–oxadiazole hybrid compounds in the whole range of medicinal chemistry and the perspectives that they hold for future research. Benzimidazole and oxadiazole cores can either be fused or incorporated using either functional groups/bonds.

Pharmacokinetics 100

Pharmacokinetics Drugs Research 100

Elrig

MARCH 25, 2025

There will also be a poster award for early-career professionals recognising the research that the next generation of scientists bring to drug discovery. In addition, the conference comprises poster presentations, networking sessions, a vendor exhibition and a tour of AstraZenecas R&D centre.

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Chemical Biology and Drug Design

MARCH 7, 2024

Abstract The research involves the synthesis of a series of new pyridine analogs 5(i-x) and their evaluation for anti-epileptic potential using in silico and in vivo models. The physicochemical, pharmacokinetic, drug-like, and drug-score features of all synthesized compounds were assessed using the online Swiss ADME and Protein Plus software.

Pharmacokinetics 100

Pharmacokinetics Drugs Research 100

Chemical Biology and Drug Design

DECEMBER 19, 2024

ADMET prediction analysis indicated that compounds 5h and 5k showed good pharmacokinetic properties. Investigation of the mechanism of action indicated that 5k down-regulated NF-B expression, possibly by suppressing LPS-induced expression of the p65 protein.

Pharmacokinetics 100

Pharmacokinetics Regulations Treatment Drugs 100

DrugBank

MARCH 19, 2025

At DrugBank, we provide researchers and clinicians with the resources they need to navigate the complexities of precision medicine. Our mission is to provide researchers and clinicians with the tools they need to navigate this complex landscape, enabling them to unlock precision medicine’s full potential.

Therapies 90

Therapies Clinical Trials Pharmacokinetics Treatment 90

The Pharma Data

NOVEMBER 17, 2020

The study demonstrated favorable proof-of-concept for LYT-100’s tolerability and pharmacokinetic (PK) profile, which will also enable twice-a-day (BID) dosing of LYT-100 in future studies. ERJ Open Research , 4(4), 00084-2018. 1 Cottin, V., Koschel, D., Günther, et al. doi:10.1183/23120541.00084-2018. Source link.

Pharmacokinetics 52

Pharmacokinetics Treatment Trials Production 52

Alta Sciences

FEBRUARY 19, 2025

Researchers must characterize the anti-drug-antibody (ADA) response in preclinical and clinical studies and report any ADA-positive samples as a risk-based approach. An oligonucleotide is a short strand of nucleotides, the building blocks of DNA or RNA, used in genetic research and therapy.

Drug Development 52

Drug Development Clinical Pharmacology Immune Response Drugs 52

Drug Target Review

JUNE 5, 2023

With a commitment to advancing novel medicines and leveraging strategic partnerships, he provides valuable insights into their cutting-edge research and development efforts. It also displayed favourable pharmacokinetics (PK) and is well tolerated in non-human primates (NHP) at exposure levels above those projected to be efficacious.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

PPD

SEPTEMBER 19, 2023

Our early development organization expanded offerings in Phase Ib patient trials to characterize the pharmacokinetics and pharmacodynamics in patients and to assess safety and early efficacy signals. We have three PPD clinical research units, located in Austin, Texas , Orlando, Florida , and Las Vegas, Nevada.

Clinical Trials 98

Clinical Trials Pharmacokinetics Drug Development Clinical Development 98

Chemical Biology and Drug Design

MAY 31, 2023

Finally, in silico results and pharmacokinetic parameters of ADME showed that these compounds have good oral bioavailability properties. According to the docking result, the most stable conformation of AChE and compound 3i showed that it has a binding affinity of −10.82 kcal/moL.

Pharmacokinetics 100

Pharmacokinetics Research 100

Chemical Biology and Drug Design

JANUARY 29, 2024

In-silico ADME studies significant values of pharmacokinetic parameters and demonstrated good drug like characteristics based on Lipinski's rule of five. In addition, the QSTR study of new compounds were carried out with the help of Toxicity Estimation Software Tool (T.E.S.T). The results showed slight toxic nature of new compounds.

Pharmacokinetics 100

Pharmacokinetics Production Drugs Research 100

DrugBank

SEPTEMBER 19, 2024

However, translating a promising therapeutic candidate into a successful oral medication presents pharmacokinetic and pharmacodynamic challenges.    Pharmacokinetics of Oral Drugs  Orally administered drugs undergo a series of biochemical processes that can affect their bioavailability and their clinical efficacy.

Pharmacokinetics 98

Pharmacokinetics Drugs Treatment Disease 98

The Pharma Data

JULY 21, 2021

These data were shared as a late-breaking oral presentation during the virtual 11 th International AIDS Society Conference on HIV Science (IAS 2021) and are a follow-up to the interim analysis that was presented earlier this year at the virtual 2021 HIV Research for Prevention Conference (HIVR4P 2021). Our Commitment to HIV.

Clinical Trials 52

Clinical Trials Pharmacokinetics Trials International 52

Drug Hunter

MAY 18, 2023

From a childhood in a small village in China’s northeast Shandong province to her work examining the drug metabolism and pharmacokinetics (DMPK) of antibody-drug conjugates (ADCs) and Bicycle toxin conjugates ® (BTCs), Dian has always looked to forge something new. researching DNA photoproducts related to skin cancer. Proteomics!

Small Molecule 131

Small Molecule DNA Pharmacokinetics Engineering 131

Drug Target Review

DECEMBER 12, 2023

We use hydrophilic linkers, which prevent ADC aggregation and generate highly stable ADCs, in combination with a unique attachment site on the antibody to create ADCs that retain pharmacokinetic properties similar to the original unconjugated antibody. This helps to maximize the targeted payload delivery to tumor cells.

Treatment 114

Treatment Engineering Pharmacokinetics Doctors 114

Chemical Biology and Drug Design

MARCH 5, 2024

The potent compounds 5d , 5e , and 5f were subjected to in silico pharmacokinetic assessment by SWISS, ADME, and pkCSM. In addition to this, molecular docking studies of compounds 5d , 5e , and 5f demonstrated that these compounds had more EGFR-binding interactions.

Pharmacokinetics 100

Pharmacokinetics Drugs Research 100

BMG Labtech

MARCH 11, 2024

They are often the method of choice to detect or measure specific biological molecules (analytes) for diagnostics, drug discovery or fundamental research. Early beginnings ELISAs were first developed in the mid-1970s independently by two research groups. Many proven applications The use of ELISAs has flourished in the life sciences.

Vaccine 98

Vaccine Molecular Biology Laboratories Virus 98

The ChEMBL-og

DECEMBER 13, 2023

Assays des cribe the experimental set-up when testing the activity of drug-like compounds against biological targets; they provide useful context for researchers interested in drug-target relationships. ADME (type A) and toxicity (type T) assays Pharmacokinetic studies provide an insight into the action and processing of a drug in vivo.

Pharmacokinetics 125

Pharmacokinetics Drugs Drug Development Science 125

Drug Target Review

NOVEMBER 1, 2023

2 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. 1-5 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. He is a researcher at University of Oldenburg, Germany.

Clinical Trials 134

Clinical Trials Trials Small Molecule Disease 134

DrugBank

OCTOBER 17, 2024

Computational chemistry and molecular modeling techniques can predict potential drug candidates' binding affinity and pharmacokinetic properties, enabling the selection of the most promising compounds for further development.

Drug Development 98

Drug Development Metabolic Stability Clinical Trials Drugs 98

Chemical Biology and Drug Design

MARCH 6, 2024

Thus, polonilignan has been identified as a new pan-cytokine and NO inhibitor, it is recommended to optimise a method for the synthesis of this small molecular weight lignan and explore its pharmacokinetic characteristics, toxicity and therapeutic effect under various chronic inflammatory disease models.

Pharmacokinetics 100

Pharmacokinetics Regulations Disease Production 100

Drug Target Review

DECEMBER 11, 2024

As a contract research organisation, we have supported numerous clients in overcoming matrix interference, particularly small and emerging biotherapeutics developers who may lack the in-house expertise to navigate such complex problems. This highlights its vital role in modern biotherapeutic research.

International 52

International Laboratories Drugs Pharmacokinetics 52

Alta Sciences

SEPTEMBER 27, 2024

Featuring two scenarios that explore the complexities of bioanalysis for immunomodulators, The Altascientist offers practical considerations for ensuring accurate bioanalysis, as well as pharmacokinetic, pharmacodynamic , and safety data in clinical trials. WHAT IS THE ALTASCIENTIST?

Clinical Trials 52

Clinical Trials Trials Pharmacokinetics Small Molecule 52

Drug Target Review

MARCH 17, 2025

The drug’s pharmacokinetics (PK) and pharmacodynamics (PD) are closely linked. Prior to this, he held the position of Vice President, overseeing various research functions responsible for identifying new targets, technologies and programme development through Phase II.

Treatment 52

Treatment Licensing Licensing Science 52

DrugBank

MARCH 7, 2024

Pharmaceutical researchers, in particular, have a keen interest in understanding the unfolding dynamics of this market. Looking Ahead As we navigate through the complexities of the weight loss drug market in 2024, pharmaceutical researchers must remain vigilant and adaptive. Let’s delve into what lies ahead in the coming year.

Pharmaceutical Companies 98

Pharmaceutical Companies Clinical Trials Pharmaceuticals Therapies 98

biobide

SEPTEMBER 29, 2023

Nowadays, the development of informatic models and the advances in Artificial Intelligence (AI) allow accurate predictions on complex biological processes such as pharmacokinetics or vast screenings of Drug candidates, based on the prediction of their pharmacological effects.

Animal Testing 106

Animal Testing Drugs Pharmacokinetics Regulations 106

Drug Target Review

JUNE 12, 2023

Leveraging AI-guided structure-based drug design, Insilico’s research and development team generated an impressive portfolio of over 6,000 molecules and identified three highly promising hit series. He is an adjunct professor of artificial intelligence at the Buck Institute for Research on Aging.

Metabolic Stability 92

Metabolic Stability Clinical Trials Small Molecule Pharmacokinetics 92

New Drug Approvals

OCTOBER 14, 2024

Avenciguat can be used in research of chronic kidney disease (CKD) and diabetic kidney disease (DKD). “Safety, tolerability, pharmacodynamics and pharmacokinetics of the soluble guanylyl cyclase activator BI 685509 in patients with diabetic kidney disease: A randomized trial” Diabetes, Obesity and Metabolism.

Pharmacokinetics 57

Pharmacokinetics Disease Trials Clinical Trials 57

Drug Target Review

NOVEMBER 15, 2023

Drug discovery is an interdisciplinary process that relies heavily on expert input from diverse and multifaceted teams, from medicinal, synthetic, and computational chemists to biologists and drug metabolism and pharmacokinetics (DMPK) scientists.

Pharmacokinetics 105

Pharmacokinetics International Laboratories Drugs 105

Drug Target Review

JUNE 6, 2023

Difficult-to-treat and rare, complicated cancers remain a perplexing challenge for IO researchers. Research has shown that these immune system proteins have the ability to trigger anti-cancer immune pathways. Currently he is Alkermes’ Oncology Fellow and Head of a Oncology Preclinical Research at the company.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

The Pharma Data

DECEMBER 17, 2020

Previous technologies have been constrained by dose-limiting toxicities, poor pharmacokinetic profiles, and attenuated efficacy. Janux’s proprietary TRACTr technology is designed to integrate tumor-specific activation with crossover pharmacokinetics to produce best-in-class T cell engager therapeutics.

Immune Response 52

Immune Response Pharmacokinetics Engineering Licensing 52