Presentation - Drug Discovery Digest

Recorded Presentations: CDD 20th Anniversary User Group Meeting

Collaborative Drug

APRIL 22, 2024

Recorded Presentations from CDD Experts

CDD Presenting at COMP Together, November 14 – UCSF Campus

Collaborative Drug

NOVEMBER 1, 2023

CDD Presenting at COMP Together, November 14 -UCSF campus

Scientists Developing Vaccine Against Present and Future COVID Viruses

Drugs.com

MAY 6, 2024

MONDAY, May 6, 2024 -- Scientists are busy working on a vaccine that might fight strains of the COVID virus SARS-CoV-2 that haven't even emerged yet.The effort from a British team at the University of Cambridge is already showing promise in mouse.

Virus

Virus Vaccine

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

CDD Exhibiting and Presenting at ACS Fall 2023, August 13th to 17th

Collaborative Drug

AUGUST 1, 2023

CDD Exhibiting and Presenting at ACS Fall 2023, August 13th to 17th.

CDD Exhibiting and Presenting at Discovery on Target 2023, Boston, September 25-28

Collaborative Drug

SEPTEMBER 21, 2023

Join CDD at Discovery on Target 2023, Sept 25-28. Explore CDD vault at Booth 209 and accelerate your product development.

Production

Models show intensifying wildfires in a warming world due to changes in vegetation and humidity; only a minor role for lightning

Science Daily: Pharmacology News

FEBRUARY 12, 2025

Climate scientists present a realistic supercomputer simulation that resolves the complex interactions between fire, vegetation, smoke and the atmosphere. The authors find that increasing greenhouse gas emissions will likely increase the global lightning frequency by about 1.6%

Milk on ice: Antarctic time capsule of whole milk powder sheds light on the enduring qualities--and evolution--of dairy products past and present

Science Daily: Pharmacology News

MARCH 27, 2024

In a remarkable discovery, whole milk powder manufactured in New Zealand in 1907 and transported to Antarctica with explorers seeking the South Pole was unveiled after more than a century. The find has allowed dairy researchers to answer the question: Is the milk we enjoy today different from the milk consumed in previous generations?

Production

Production Research

New data showcase promise, growing pains of CAR-T in autoimmune disease

BioPharma Drive: Drug Pricing

JUNE 17, 2024

One expert described trial results presented at EULAR last week as “unprecedented.” ” But reports of relapses in some patients drew questions about the therapies’ ultimate potential.

Disease

Disease Therapies Trials

Methods for Kinetic Evaluation of Reversible Covalent Inhibitors from Time-Dependent IC50 Data

Covalent Modifiers

MARCH 24, 2025

Herein, we present an implicit equation that can estimate these constants from incubation time-dependent IC50 values and a numerical modelling method, EPIC-CoRe, that can fit these kinetic parameters from pre-incubation time-dependent IC50 data.

Drugs

The risk of global water scarcity is greater when accounting for the origin of rain

Science Daily: Pharmacology News

SEPTEMBER 2, 2024

Researchers are now presenting an alternative method for quantifying the global risk of water scarcity. Securing the world's water supply is one of the greatest challenges of our time.

Government

Government Research

Forever Chemicals found in bottled and tap water from around the world

Science Daily: Pharmacology News

OCTOBER 17, 2024

Scientists have discovered toxic 'Forever Chemicals' present in samples of drinking water from around the world.

Organic material from Mars reveals the likely origin of life's building blocks

Science Daily: Pharmacology News

JULY 1, 2024

The study presents solid evidence for a prediction made over a decade ago that could be key to understanding how organic molecules, the foundation of life, were first formed here on Earth. Two samples from Mars together deliver clear evidence of the origin of Martian organic material.

First conclusive evidence that a terrestrial leech species can jump

Science Daily: Pharmacology News

JUNE 20, 2024

A new study presents video evidence that at least one species of terrestrial leech can jump, behavior that scientists have debated for more than a century.

Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Covalent Modifiers

FEBRUARY 10, 2025

This work presents the identification and early-stage optimization of small molecule fragment-like stabilizers for a specific binding site of the 14-3-3/Tau PPI.

Biophysical Assays

Biophysical Assays Small Molecule Engineering Regulations

An ant that selectively amputates the infected limbs of wounded sisters

Science Daily: Pharmacology News

JULY 2, 2024

When experimentally testing the effectiveness of these 'treatments,' not only did they aid in recovery, but the research team found the ants' choice of care catered to the type of injury presented to them.

Treatment

Treatment Research

New evidence pushes back arrival of early hominins in Europe

Science Daily: Pharmacology News

JANUARY 24, 2025

Research reveals new evidence of early hominin activity in Europe, suggesting that hominins were present on the continent far earlier than previously thought.

Research

Dinosaurs roamed the northern hemisphere millions of years earlier than previously thought, according to new analysis of the oldest North American fossils

Science Daily: Pharmacology News

JANUARY 7, 2025

A newly described dinosaur whose fossils were recently uncovered is challenging the existing narrative, with evidence that the reptiles were present in the northern hemisphere millions of years earlier than previously known.

Return of the elephants seals: From a few to thousands

Science Daily: Pharmacology News

SEPTEMBER 27, 2024

The research shows that this species narrowly escaped extinction by hunting, resulting in lasting genetic effects in the present population. A new international study has revealed the genetic impact of hunting in northern elephant seals.

International

International Research

Some mice may owe their monogamy to a newly evolved type of cell

Science Daily: Pharmacology News

MAY 15, 2024

Scientists discover the cells and hormones that inspire mice to nurture their young; the same hormones are also present in humans. The answer may be a previously unknown hormone-generating cell.

Genetic tracing at the Huanan Seafood market further supports COVID animal origins

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC).

Marketing

Marketing Virus Disease

CG follows big IPO with new results for bladder cancer drug

BioPharma Drive: Drug Pricing

MAY 3, 2024

Newly disclosed Phase 3 results presented Friday match findings the biotech disclosed last year, while offering a more comprehensive look at how its drug stacks up to rival therapies.

Drugs

Drugs Therapies

When did human language emerge?

Science Daily: Pharmacology News

MARCH 18, 2025

Humans' unique language capacity was present at least 135,000 years ago, according to a survey of genomic evidence. As such, language might have entered social use 100,000 years ago.

More plants on the menu of ancient hunter-gatherers

Science Daily: Pharmacology News

APRIL 29, 2024

A new study challenges this notion by presenting compelling isotopic evidence of a strong preference for plants among 15,000-year-old hunter-gatherers from Morocco. However, due to the scarcity of well-preserved human remains from Paleolithic sites, little information exists about the dietary habits of pre-agricultural human groups.

Ancient DNA reveals Indigenous dog lineages found at Jamestown, Virginia

Science Daily: Pharmacology News

AUGUST 16, 2024

Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day. To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs.

DNA

DNA Research

Biodegradable 'living plastic' houses bacterial spores that help it break down

Science Daily: Pharmacology News

APRIL 30, 2024

Researchers have developed a biodegradable form of thermoplastic polyurethane (TPU) filled with bacterial spores that, when exposed to nutrients present in compost, germinate and break down the material at the end of its life cycle. A new type of bioplastic could help reduce the plastic industry's environmental footprint.

Research

Roche weighs whether speedy approval path is open for latest Alzheimer’s drug

BioPharma Drive: Drug Pricing

OCTOBER 31, 2024

In an investor presentation, executives hinted at the possibility of seeking an accelerated approval of trontinemab if it can significantly lower levels of amyloid in a Phase 3 trial.

Trials

Trials Drugs

Global retreat of glaciers has strongly accelerated

Science Daily: Pharmacology News

FEBRUARY 19, 2025

Researchers present a global assessment of ice loss since the beginning of the millennium. In a global comparison, the glaciers in the Alps and Pyrenees are melting the fastest.

Research

After years of disappointment, cancer vaccines show new promise

BioPharma Drive: Drug Pricing

JUNE 8, 2023

Moderna presented new data at ASCO for its melanoma shot, highlighting progress with a personalized approach that’s also being pursued by BioNTech and Gritstone.

Vaccine

Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM

Covalent Modifiers

FEBRUARY 6, 2025

Herein, we present mutational and structural investigations on understudied ubiquitous MtCK that showed closure of the loop comprising His61 is specific to and relies on creatine binding and mechanism of phosphoryl transfer depends on electrostatics of active site.

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Science Daily: Pharmacology News

OCTOBER 17, 2024

The work presents a method for manipulating the photonic states of light in a never-before-seen way, offering greater control over the evolution of photon propagation. This control makes it possible to improve the detection and number of photon coincidences, as well as the efficiency of the system.

Research

Rewriting the evolutionary history of critical components of the nervous system

Science Daily: Pharmacology News

AUGUST 13, 2024

The study shows that the Shaker family of ion channels were present in microscopic single cell organisms well before the common ancestor of all animals and thus before the origin of the nervous system.

Neuroscientists spark shelter-seeking response by reactivating memory circuit

Science Daily: Pharmacology News

OCTOBER 1, 2024

Using a sophisticated brain-imaging system, neuroscientists say they have successfully reactivated a specific memory circuit in mice, causing them to seek out shelter when no shelter is actually present.

Weight-Loss Pill Saxenda Helps Kids as Young as 6

Drugs.com

SEPTEMBER 11, 2024

11, 2024 -- The weight-loss drug liraglutide helped obese children lower their BMI and reach a healthier weight, researchers report.The findings, published Tuesday in the New England Journal of Medicine and presented. WEDNESDAY, Sept.

Research

Research Drugs

Alcohol raises heart disease risk, particularly among women

Science Daily: Pharmacology News

MARCH 28, 2024

Young to middle-aged women who reported drinking eight or more alcoholic beverages per week--more than one per day, on average--were significantly more likely to develop coronary heart disease compared with those who drank less, finds a study presented at the American College of Cardiology's Annual Scientific Session.

Disease

1 In 15 Americans Have Survived A Mass Shooting, Survey Says

Drugs.com

MARCH 10, 2025

MONDAY, March 10, 2025 -- A startling number of Americans have witnessed a mass shooting in their lifetime, a new study suggests.About 1 in 15 adults have been present at the scene of a mass shooting, and more than 2% have been injured in one.

Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

These compounds bring together two proteins in the cell that might not normally find each other a target protein (often the one altered in disease), and a presenter protein that has some effect on the target. For their presenter protein, they chose FKBP12, a well-studied protein that is abundant in human cells.

Disease

Disease Research DNA Small Molecule

New Hope Against a Rare, Aggressive Form of Thyroid Cancer

Drugs.com

OCTOBER 28, 2024

But some patients can present with what's known as an anaplastic thyroid carcinoma (ATC) -- a rare and very aggressive tumor with a very poor prognosis. MONDAY, Oct. 28, 2024 -- Most thyroid cancers are slow-moving and, if caught early, curable.

Space oddity: Most distant rotating disc galaxy found

Science Daily: Pharmacology News

OCTOBER 7, 2024

Dubbed REBELS-25, this disc galaxy seems as orderly as present-day galaxies, but we see it as it was when the Universe was only 700 million years old. Researchers have discovered the most distant Milky-Way-like galaxy yet observed.

Research

Nanosized blocks spontaneously assemble in water to create tiny floating checkerboards

Science Daily: Pharmacology News

JUNE 13, 2024

The work presents a simple approach to create complex nanostructures through a technique called self-assembly. Researchers have engineered nanosized cubes that spontaneously form a two-dimensional checkerboard pattern when dropped on the surface of water.

Engineering

Engineering Research

Weather-changing El Nino oscillation is at least 250 million years old

Science Daily: Pharmacology News

OCTOBER 21, 2024

A new modeling study shows that the El Nino event, a huge blob of warm ocean water in the tropical Pacific Ocean that can change rainfall patterns around the globe, was present at least 250 million years in the past, and was often of greater magnitude than the oscillations we see today.

Diverse gut bacteria communities protect against harmful pathogens by nutrient blocking

Science Daily: Pharmacology News

DECEMBER 14, 2023

However, this protective effect is lost when only single species of gut bacteria are present. New study demonstrates that diverse communities of resident bacteria can protect the human gut from disease-causing microorganisms.

Disease

Disease Research

Oldest-known evolutionary 'arms race'

Science Daily: Pharmacology News

JANUARY 3, 2025

A new study presents what is believed to be the oldest known example in the fossil record of an evolutionary arms race.

Two of the Milky Way's earliest building blocks identified

Science Daily: Pharmacology News

MARCH 21, 2024

The new find is the astronomical equivalent of archeologists identifying traces of an initial settlement that grew into a large present-day city.

Beyond the 'Dragon Arc', a treasure trove of unseen stars

Science Daily: Pharmacology News

JANUARY 6, 2025

Taking advantage of a cosmic 'double lens,' astronomers resolved more than 40 individual stars in a galaxy so far away its light dates back to when the universe was only half its present age.

Recorded Presentations: CDD 20th Anniversary User Group Meeting

CDD Presenting at COMP Together, November 14 – UCSF Campus

Webinars

Trending Sources

Scientists Developing Vaccine Against Present and Future COVID Viruses

Webinars

CDD Exhibiting and Presenting at ACS Fall 2023, August 13th to 17th

CDD Exhibiting and Presenting at Discovery on Target 2023, Boston, September 25-28

Models show intensifying wildfires in a warming world due to changes in vegetation and humidity; only a minor role for lightning

Milk on ice: Antarctic time capsule of whole milk powder sheds light on the enduring qualities--and evolution--of dairy products past and present

New data showcase promise, growing pains of CAR-T in autoimmune disease

Methods for Kinetic Evaluation of Reversible Covalent Inhibitors from Time-Dependent IC50 Data

The risk of global water scarcity is greater when accounting for the origin of rain

Forever Chemicals found in bottled and tap water from around the world

Organic material from Mars reveals the likely origin of life's building blocks

First conclusive evidence that a terrestrial leech species can jump

Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

An ant that selectively amputates the infected limbs of wounded sisters

New evidence pushes back arrival of early hominins in Europe

Dinosaurs roamed the northern hemisphere millions of years earlier than previously thought, according to new analysis of the oldest North American fossils

Return of the elephants seals: From a few to thousands

Some mice may owe their monogamy to a newly evolved type of cell

Genetic tracing at the Huanan Seafood market further supports COVID animal origins

CG follows big IPO with new results for bladder cancer drug

When did human language emerge?

More plants on the menu of ancient hunter-gatherers

Ancient DNA reveals Indigenous dog lineages found at Jamestown, Virginia

Biodegradable 'living plastic' houses bacterial spores that help it break down

Roche weighs whether speedy approval path is open for latest Alzheimer’s drug

Global retreat of glaciers has strongly accelerated

After years of disappointment, cancer vaccines show new promise

Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Rewriting the evolutionary history of critical components of the nervous system

Neuroscientists spark shelter-seeking response by reactivating memory circuit

Weight-Loss Pill Saxenda Helps Kids as Young as 6

Alcohol raises heart disease risk, particularly among women

1 In 15 Americans Have Survived A Mass Shooting, Survey Says

Researchers devise new way to target and correct disease-related proteins

New Hope Against a Rare, Aggressive Form of Thyroid Cancer

Space oddity: Most distant rotating disc galaxy found

Nanosized blocks spontaneously assemble in water to create tiny floating checkerboards

Weather-changing El Nino oscillation is at least 250 million years old

Diverse gut bacteria communities protect against harmful pathogens by nutrient blocking

Oldest-known evolutionary 'arms race'

Two of the Milky Way's earliest building blocks identified

Beyond the 'Dragon Arc', a treasure trove of unseen stars

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