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Metabolism of macrocyclic drugs

Metabolite Tales Blog

Figure 1 Metabolism of simeprevir Glecaprevir (ABT493/A-1282576) is another antiviral drug for the treatment of chronic hepatitis C which also undergoes limited CYP3A4/5 mediated metabolism in vitro , and for which all human metabolites were present in at least one animal species. Journal of Medicinal Chemistry 62 (21), 9418-9437.

Drugs 52
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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

Figure 1 Metabolism of simeprevir Glecaprevir (ABT493/A-1282576) is another antiviral drug for the treatment of chronic hepatitis C which also undergoes limited CYP3A4/5 mediated metabolism in vitro , and for which all human metabolites were present in at least one animal species. Journal of Medicinal Chemistry 62 (21), 9418-9437.