Chemical Biology and Drug Design

APRIL 1, 2023

Berberine has been shown in in vitro and in vivo studies to inhibit various types of cancer by activating the p-53 and cyclin-B expression, targeting various cell signalling pathways, to regulate the cell cycle. Berberine anticancer properties are demonstrated due to the interaction of berberine with micro-RNA.

Therapies 100

Therapies RNA Regulations Research 100

Chemical Biology and Drug Design

DECEMBER 1, 2023

At present, it has not been reported whether BD inhibits the malignancy of colorectal cancer (CRC) cells. circinteractome, and CircBank and validated using dual-luciferase reporter and RNA pull-down assays. Importantly, circ_0068464 could regulate ATG5 expression by functioning as a miR-520h molecular sponge.

RNA 100

RNA Regulations Treatment Drugs 100

Codon

AUGUST 26, 2024

For this reason, developing broad-spectrum antivirals presents an enormous scientific challenge. Remdesivir and other broad-spectrum antivirals work by jamming up RNA-dependent RNA polymerase (RdRp), an enzyme that nearly all RNA viruses use to replicate their genomes. Existing medicines only pose a partial solution.

RNA 102

RNA Virus DNA Vaccine 102

KIF1A

SEPTEMBER 16, 2023

Note: For simplicity I will use the term KIF1A when referring to UNC-104 Post-translational modifications: When we talk about modifications to proteins, it’s usually in the context of mutations – a modification to the KIF1A gene makes altered RNA, which translates into altered KIF1A protein.

Regulations 105

Regulations RNA Disease Research 105

Drug Target Review

AUGUST 9, 2023

FTD is a neurodegenerative disease characterised by the progressive death of Glutamatergic and GABAergic neurons in the frontal and temporal lobes, with some evidence pointing to decreases in neurotransmitters like GABA contributing to disease presentation. 14 Image modified from Suk et al.

RNA 98

RNA Regulations Disease DNA 98

Drug Target Review

SEPTEMBER 25, 2024

BRAF and downstream mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors are combined to treat BRAF-mutated melanoma, for example. 5 Here, the original oncogene is still present but the transdifferentiated cancer cells are less dependent on it.

Small Molecule 105

Small Molecule Therapies Regulations Treatment 105

Broad Institute

MARCH 6, 2024

In the new study, McCarroll, Berretta, and colleagues used single-nucleus RNA sequencing, which measures gene expression in individual cells, to better understand how the brain naturally varies across individuals. They analyzed 1.2 million cells from 94 people with schizophrenia and 97 without.

Medical Schools 134

Medical Schools RNA Science Research 134

KIF1A

SEPTEMBER 9, 2023

These cells are present in embryos, where they populate the brain by dividing: When a radial glial progenitor (RGP) divides it can make two radial glial progenitor copies to increase cell number, or it can make a single copy as well as a mature neuron. Falnikar et al.

RNA 105

RNA Treatment Research Disease 105

Codon

DECEMBER 12, 2024

It’s important to note that the 300-page report, while presenting detailed evidence for the potential harms of mirrored life, uses painstakingly speculative language. DNA and RNA molecules are also built from exclusively right-handed nucleic acids. It gives humanity time to steer away. This is one of them.

DNA 104

DNA RNA Vaccine Virus 104

Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. When the researchers compared the architecture of regulatory and effector T cells, they found there were many unique Foxp3 binding regions only present in regulatory T cells.

Government 104

Government DNA RNA Regulations 104

Drug Target Review

AUGUST 22, 2023

Today’s researchers are using a wide range of modalities, including advanced approaches such as gene therapy and CRISPR, transcription regulators, RNA and protein degraders as well as more traditional approaches such as vaccines and antibodies. However, this disease has proven a hard nut to crack.

Therapies 98

Therapies Disease Treatment RNA 98

Drug Target Review

JUNE 6, 2023

In the context of a tumour microenvironment, Tregs are often present in high numbers, preventing an effective immune response to the tumour. 2 After activation by an antigen presenting cell, a T helper cell segregates the cytokines. Some approaches have already reached the clinical trial stage, with others not far behind.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

DrugBank

JULY 24, 2024

Additionally, while small molecules can target well-defined pockets on enzymes or receptors, targeting PPIs presents a unique challenge due to their flat, featureless interfaces and large interaction areas. Despite these challenges, the progress in PPI-modulating drugs is noteworthy.

Small Molecule 98

Small Molecule Drugs Clinical Trials Therapies 98

Broad Institute

JUNE 30, 2023

LipocyteProfiler is a powerful imaging technique that generates comprehensive microscopy-based profiles of cells using multiple fluorescent dyes chosen specifically for studies of cardiometabolic biology.

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

New Drug Approvals

SEPTEMBER 6, 2024

Toll/IL-1 receptor family members are important regulators of inflammation and host resistance. TLR7-9 are among the set that are endosomally located and respond to single-stranded RNA (TLR7and TLR8) or unmethylated single-stranded DNA containing cytosine-phosphate-guanine (CpG) motifs (TLR9). Nature Immunol., 11:373-384 (2010)).

RNA 62

RNA Clinical Trials Disease DNA 62

KIF1A

OCTOBER 15, 2024

The researchers also reassured my parents about the therapies to follow while waiting for a cure and presented encouraging results from a specific experimental drug that acts on messenger RNA. I also take antiepileptic, mood, and sleep regulators. It was an incredible experience! I met other children and adults like me.

RNA 52

RNA Therapies Treatment Regulations 52

Broad Institute

OCTOBER 4, 2023

Today, scientists use such reactions to produce the customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and more. Wang concluded her presentation by expressing gratitude to Merkin. I’m really thankful for the support of the Merkin Fellowship,” she said. “It

DNA 52

DNA RNA Science Protein Expression 52

Codon

JUNE 25, 2024

Sometimes cells don’t take up the DNA, or unforeseen issues with the modified sequence arise—such as off-target mutations, unexpected protein modifications, or disruptions to gene regulation—that send us back to the drawing board. Proteins are colored blue and RNA molecules are colored orange and yellow.

DNA 82

DNA RNA Laboratories Research 82

BMG Labtech

DECEMBER 20, 2024

Absorbance measurements at this specific wavelength can be used to determine DNA or RNA concentrations quickly. The conversion of a substrate by the enzyme bound to the secondary antibody into a chromophore is used to allow for measurement by absorbance and quantification of the amount of the specific protein present in the sample.

DNA 52

DNA Science Laboratories RNA 52

Drug Target Review

APRIL 3, 2024

So far, GDF-15 has mainly been known as an important factor in feto-maternal tolerance and a regulator of nausea, anorexia, and food aversion in different diseases, including cancer and the pregnancy complication hyperemesis gravidarum. Nevertheless, effectively harnessing the vast volume of generated data remains a formidable challenge.

Science 105

Science Clinical Development Treatment DNA 105

DrugBank

JANUARY 29, 2025

These disorders, often characterized by a loss-of-function mutation in a crucial gene, can manifest with a wide range of clinical presentations, depending on the specific gene and its role in cellular physiology. The system comprises a guide RNA that targets a specific DNA locus and the Cas9 enzyme that cleaves the DNA at the target site.

Therapies 52

Therapies DNA RNA Disease 52

The Pharma Data

JANUARY 21, 2021

In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 50 copies per milliliter [c/mL] at Week 48), with a comparable number of patients receiving either CABENUVA or their daily current antiretroviral regimen (CAR) having an HIV-1 RNA level ?50

FDA Approval 52

FDA Approval Treatment RNA FDA 52

Drug Target Review

JULY 1, 2024

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. The single-cell transcriptomic analysis in the Sci Reports paper 1 provides insights into SRP-001’s pain-relief mechanisms.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Codon

APRIL 2, 2023

Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). By combining this new variant with standard sequencing methods, it’s possible to identify RNA modifications in a really simple way. Nucleic Acids Research. Communications Biology.

DNA 52

DNA RNA Engineering Licensing 52

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. Because it turns out that at least half of them , in humans, also bind to RNA molecules. How do transcription factors couple up with the correct RNA molecule? No longer.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. Because it turns out that at least half of them , in humans, also bind to RNA molecules. How do transcription factors couple up with the correct RNA molecule? No longer.

Therapies 52

Therapies RNA DNA Engineering 52

The Pharma Data

MAY 7, 2021

Despite PRAC’s ongoing surveillance and review, no safety signal is being found for the low platelet and clotting syndrome with either of the two authorized messenger RNA (mRNA) vaccines. The regulator has asked AstraZeneca for a detailed analysis of these cases when the firm submits its next required monthly safety report. .

Vaccine 40

Vaccine RNA Laboratories Production 40

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

The Pharma Data

MARCH 23, 2022

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. “This presents additional hurdles for polymerase,” says Fang. But targeting Ebola virus polymerase has proven tough.

Virus 52

Virus Small Molecule Protein Production Research 52

The Pharma Data

AUGUST 30, 2021

Results were presented at the ESC Congress 2021, organized by the European Society of Cardiology (ESC). As the first and only small interfering RNA to provide effective and sustained LDL-C reduction, Leqvio helps manage a critical cardiovascular risk factor for ASCVD. It is currently under review by the U.S.

RNA 52

RNA Disease Trials Therapies 52

Codon

APRIL 2, 2024

Hermann Bujard had done careful work analyzing the features of bacterial promoters that could allow them to be both strong and tightly regulated, two of the key properties necessary for the repressilator to work. Slides from a lab talk presented in Heidelberg, Germany in 1998. The exported RNA could transfect just the target cell.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

SugarCone Biotech

MAY 28, 2019

But first, these new papers are gorgeous: The study presented by Petitprez et al. And we must recall that PD-1/PD-L1 interaction in lymphoid organ germinal centers regulates T cell / B cell interactions ( [link] ). is focused on the response of sarcomas to immunotherapy ( [link] ). T and B cell mediated immunity.

Immune Response 52

Immune Response Therapies Production Vaccine 52

Codon

APRIL 30, 2023

Read This paper explains how synthetic biology is regulated in Europe. Read Ribosomes are able to build proteins because they contain a strand of RNA that imbues them with their catalytic power. Read Another browser-based tool, except this one lets you draw RNA strands much like you would paint on a canvas. Synthetic Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read This paper explains how synthetic biology is regulated in Europe. Read Ribosomes are able to build proteins because they contain a strand of RNA that imbues them with their catalytic power. Read Another browser-based tool, except this one lets you draw RNA strands much like you would paint on a canvas. Synthetic Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

The Pharma Data

AUGUST 29, 2020

Presented at the ESC Congress 2020, the annual meeting of the European Society of Cardiology, the analysis evaluated the efficacy and tolerability of inclisiran on top of a maximally tolerated dose of statins, in two studies of more than 2,300 patients (of which 1,164 were on inclisiran) from the Phase III trials. 2020;382:1507-1519.

Treatment 52

Treatment Disease Therapies Trials 52

New Drug Approvals

SEPTEMBER 29, 2024

In addition, older dogs had bacterial antigens and ribosomal RNA in their brains, consistent with systemic infection seen in humans. According to a presentation at the 2020 CTAD, GAIN was fully enrolled. gingivalis DNA, according to data presented at CTAD 2021 in November. This trial involves 93 sites in the U.S. and Europe.

Small Molecule 62

Small Molecule DNA Disease Trials 62

The Pharma Data

JANUARY 6, 2021

Its products and services are designed to benefit people by supporting efforts to overcome the major challenges presented by a growing and aging global population. About Bayer Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Capital expenditures amounted to 2.9 billion euros.

Vaccine 52

Vaccine Production Marketing RNA 52