Covalent Modifiers

MAY 10, 2023

Liganded sites were enriched for RNA-binding and protein–protein interaction (PPI) domains, including several sites found in RNP granule-forming proteins. In summary, we present a chemical strategy for the systematic discovery of condensate-modulating covalent small molecules.

Small Molecule 130

Small Molecule RNA 130

ASPET

JULY 19, 2023

Ras- G TPase-activating protein (SH 3 domain)- b inding p roteins (G3BP) are RNA binding proteins that plays a critical role in stress granule (SG) formation. Recent evidence suggests that G3BPs can also regulate mRNA expression through interactions with RNA outside of SGs.

RNA 100

RNA Virus Regulations Disease 100

Conversations in Drug Development Trends

MAY 30, 2024

This approach is facilitated by developing ASOs and RNA interference (RNAi) therapies, which target the various molecular and genetic mechanisms contributing to ALS pathophysiology and disease progression. The post Present Treatments & Hopeful Future Directions for ALS Pharmacotherapies appeared first on Worldwide Clinical Trials.

Treatment 81

Treatment Clinical Trials Small Molecule Therapies 81

Fierce BioTech

JULY 1, 2024

Streamlining the Path from Discovery to Patient – Simpler RNA Manufacturing with Aldevron’s Codex® HiCap RNA Polymerase swheeler Mon, 07/01/2024 - 17:17 Wed, 08/07/2024 - 10:00 Resource Type Webinar Kyle Studey, M.S. Codex ® is a trademark of Codexis, Inc. Listing Image aldevron 250x190.png

RNA 40

RNA Engineering Research 40

Drug Target Review

JULY 24, 2023

Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma. The initial subject of my research carrier was RNA polymerase principal sigma factors in bacteria. What is the role of the apicoplast in the malaria parasite Plasmodium falciparum ?

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Drug Target Review

APRIL 7, 2025

Haemoglobin A1c (HbA1c) is a validated surrogate endpoint for the reduction of microvascular complications associated with diabetes mellitus; reduced HIV-RNA levels serve as an endpoint for HIV disease control; and a reduction in low-density lipoprotein (LDL) cholesterol is used as an endpoint indicating lower likelihood of cardiovascular events.

Clinical Development 59

Clinical Development Clinical Trials Clinical Pharmacology Trials 59

Drug Target Review

JULY 5, 2023

At PEGS Europe, Drug Target Review spoke to Victoria Goldenshtein, a PhD candidate in Biomedical Engineering at Duke University, US, who presented an engaging poster on her lab’s novel in vitro library display platform for directed protein evolution termed GRIP Display, which entails Gluing RNA to Its Proteins.

RNA 97

RNA Engineering Disease Drugs 97

Chemical Biology and Drug Design

DECEMBER 28, 2023

The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. In present study, LINC00460 was screened out through bioinformatics analysis. Abstract The acquired resistance of cancer to cisplatin (DDP) limits the efficacy of chemotherapy.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

Small Molecule 52

Small Molecule RNA Clinical Trials Drugs 52

The Pharma Data

FEBRUARY 8, 2021

The amended protocol being implemented for all ongoing adult and adolescent fitusiran clinical studies was presented today at the 14 th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD). Sanofi’s priority is the safety of patients.

RNA 52

RNA Treatment Vaccine Therapies 52

Codon

AUGUST 26, 2024

For this reason, developing broad-spectrum antivirals presents an enormous scientific challenge. Remdesivir and other broad-spectrum antivirals work by jamming up RNA-dependent RNA polymerase (RdRp), an enzyme that nearly all RNA viruses use to replicate their genomes. Existing medicines only pose a partial solution.

RNA 97

RNA Virus DNA Vaccine 97

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. Using genetic sequencing technologies, Whiteley and Cao measured the levels of all types of mRNA present in the bacteria. They named the small RNA SicX (sRNA inducer of chronic infection X).

RNA 40

RNA Regulations Treatment Research 40

Chemical Biology and Drug Design

DECEMBER 1, 2023

At present, it has not been reported whether BD inhibits the malignancy of colorectal cancer (CRC) cells. circinteractome, and CircBank and validated using dual-luciferase reporter and RNA pull-down assays. BD could restrain CRC growth through repressing the circ_0068464/miR-520h/ATG5 axis.

RNA 100

RNA Regulations Treatment Drugs 100

Chemical Biology and Drug Design

APRIL 1, 2023

Berberine anticancer properties are demonstrated due to the interaction of berberine with micro-RNA. The summarized information presented in this review article may help and lead the researchers, scientists/industry persons to use berberine as a promising candidate against cancer.

Therapies 100

Therapies RNA Regulations Research 100

Chemical Biology and Drug Design

SEPTEMBER 15, 2023

CRS rabbit models were constructed by Staphylococcus aureus infection and rabbits were injected with lentiviral vectors of short hairpin RNA-targeting Chemerin (shChemerin), followed by micro-computed tomography (CT) scan. Patients suffering from CRS without/with nasal polyps (CRSsNP/CRSwNP), along with volunteers, were recruited.

RNA 100

RNA Treatment Disease Research 100

DrugBank

MAY 22, 2024

In the dynamic world of drug discovery, the notion of "undruggable" targets presents both a significant challenge and an intriguing frontier for researchers and pharmaceutical companies. Beyond Proteins: DNA and RNA Frontier The story doesn’t end with proteins.

Small Molecule 96

Small Molecule RNA DNA Pharmaceutical Companies 96

The Pharma Data

SEPTEMBER 6, 2021

First data to be presented from the phase II coopERA Breast Cancer study evaluating neoadjuvant giredestrant treatment for oestrogen receptor (ER)-positive, HER2-negative breast cancer. Breast Cancer Highlights. Lung Cancer Highlights.

Treatment 52

Treatment Therapies DNA Trials 52

ASPET

MARCH 26, 2024

The messenger RNA for human H 1 -histamine-receptors was present in cardiac samples from H 1 -TG and absent from WT. In H 1 -TG mice, we ascertained the presence of H 1 -histamine receptors by autoradiography of atrium and ventricle using [ 3 H]mepyramine.

RNA 100

RNA 100

The Pharma Data

MARCH 9, 2021

and Shionogi Limited as shareholders, presented positive data from its phase IIa proof-of-concept study of the investigational maturation inhibitor GSK3640254 (GSK’254). These findings were presented today at the (virtual) 2021 Conference on Retroviruses and Opportunistic Infections (CROI). log 10 and -2.0

Treatment 52

Treatment RNA Pharmacokinetics Virus 52

The Pharma Data

JULY 12, 2021

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced the presentation of data from the company’s HIV clinical development program at the 11th International AIDS Society Conference on HIV Science (IAS 2021) from July 18-21. Late Breaking Oral Presentation OALC01LB03. On-Demand Oral Presentation OAB0304.

Pharmacokinetics 52

Pharmacokinetics Clinical Trials Trials Treatment 52

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Senior Director, R&D Strategy, will be delivering a presentation highlighting how Strateos' smart lab platform accelerated riboswitch engineering to develop novel biosensors. Learn how Strateos’ automated synthetic biology modules supported rapid, iterative screening of RNA sequences in modular pbuE expression system and E.

Engineering 52

Engineering Protein Expression Research Laboratories RNA 52

Codon

DECEMBER 12, 2024

It’s important to note that the 300-page report, while presenting detailed evidence for the potential harms of mirrored life, uses painstakingly speculative language. DNA and RNA molecules are also built from exclusively right-handed nucleic acids. It gives humanity time to steer away. This is one of them.

RNA 102

RNA DNA Vaccine Virus 102

The Pharma Data

OCTOBER 28, 2021

ViiV Healthcare presents positive interim data showing Vocabria (cabotegravir) and Rekambys (rilpivirine) can be enforced successfully in a variety of European healthcare settings. 1), (2), (3) Interim findings were presented at the 18th European AIDS Conference (EACS 2021) being held 27-30 October. 5) HarmonyP.

Pharmaceutical Companies 52

Pharmaceutical Companies Treatment RNA Pharmaceuticals 52

The Pharma Data

MARCH 8, 2021

The data were presented at the 28th Conference on Retroviruses and Opportunistic Infections ( virtual CROI 2021). These data reinforce that Biktarvy provides durable viral suppression, strong efficacy and a high barrier to resistance in both adults that are new to HIV therapy and those replacing their existing treatment.”.

Treatment 52

Treatment Therapies RNA Laboratories 52

The Pharma Data

FEBRUARY 12, 2022

This data will be presented at the 29th Conference on Retroviruses and Opportunistic Infections (virtual CROI 2022) taking place from February 12-16. Veklury directly inhibits viral replication inside of the cell by targeting the SARS-CoV-2 viral RNA polymerase.

Pharmacokinetics 52

Pharmacokinetics RNA Hospitals Laboratories 52

DrugBank

MARCH 12, 2025

Introduction Messenger RNA (mRNA) technology has emerged as one of the most significant medical breakthroughs. Once delivered into the body, the mRNA instructs cells to produce these antigens, which are then presented to the immune system.

Vaccine 97

Vaccine Treatment Clinical Trials Therapies 97

Broad Institute

SEPTEMBER 28, 2023

Macosko knew samples from these living patients presented a rare chance to observe cells exposed to the initial stages of Alzheimer’s pathology. Over the next few years, his team used single-nucleus RNA sequencing, which maps gene expression in individual cell nuclei, to analyze the brain tissue.

Disease 144

Disease Medical Schools Research Hospitals 144

Codon

NOVEMBER 3, 2024

If present before vaccination, memory immune cells primed to destroy the environmental relatives might cross-react with and neutralize the BCG strain before it has a chance to set up an immune response against itself and M. During vaccination, the BCG strain normally primes immune cells to destroy infections, and owing to its similarity to M.

Vaccine 96

Vaccine Trials Therapies Treatment 96

KIF1A

SEPTEMBER 16, 2023

Note: For simplicity I will use the term KIF1A when referring to UNC-104 Post-translational modifications: When we talk about modifications to proteins, it’s usually in the context of mutations – a modification to the KIF1A gene makes altered RNA, which translates into altered KIF1A protein.

Regulations 105

Regulations RNA Disease Research 105

Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. At present, we test discarded human livers deemed not good enough for transplant. When combined with our in-house GMP-level RNA chemistry lab, Ochre Bio is able to progress from a new target to generating human data on a lead therapy in days.

Therapies 102

Therapies Disease RNA Engineering 102

Broad Institute

AUGUST 19, 2024

Using RNA sequencing and working with the Broad’s Metabolomics Platform and collaborators at St. Jude’s, the team identified a group of genes involved in processing uLCFAs that are present only in the non- Lactobacillus iners species.

Hospitals 121

Hospitals Treatment Medical Schools Science 121

Drug Target Review

AUGUST 9, 2023

FTD is a neurodegenerative disease characterised by the progressive death of Glutamatergic and GABAergic neurons in the frontal and temporal lobes, with some evidence pointing to decreases in neurotransmitters like GABA contributing to disease presentation. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.”

RNA 98

RNA Regulations Disease DNA 98

Broad Institute

MARCH 6, 2024

In the new study, McCarroll, Berretta, and colleagues used single-nucleus RNA sequencing, which measures gene expression in individual cells, to better understand how the brain naturally varies across individuals. They analyzed 1.2 million cells from 94 people with schizophrenia and 97 without.

Medical Schools 134

Medical Schools RNA Science Research 134

Drug Target Review

AUGUST 28, 2024

We then incubate the cells to mature into ‘pro-regenerative’ macrophages and insert two RNA messages to produce two human proteins that will be expressed at the site of injury when these ‘engineered’ macrophages are given back to the patient. The patient’s own monocytes, a type of white blood cell, are removed via an apheresis procedure.

Therapies 116

Therapies Disease Engineering Medical Schools 116

Drug Target Review

APRIL 9, 2024

Our approach to investigate the toxicity driven by nucleolar stress was to induce it with certain arginine-rich peptides, present in patients of ALS, which were known to accumulate at nucleoli and cause this type of stress. However, our study was first to show that inducing nucleolar stress in an adult mammal accelerates aging.

RNA 64

RNA Cell Biology Clinical Development Disease 64

The Pharma Data

MARCH 8, 2021

These preliminary findings were presented today during Science Spotlights TM at the 2021 Conference on Retroviruses and Opportunistic Infections (CROI 2021). Findings from the primary efficacy and safety endpoints and additional secondary objectives will be presented at an upcoming medical meeting. About Molnupiravir.

Trials 69

Trials Virus RNA Research Laboratories 69

KIF1A

SEPTEMBER 9, 2023

These cells are present in embryos, where they populate the brain by dividing: When a radial glial progenitor (RGP) divides it can make two radial glial progenitor copies to increase cell number, or it can make a single copy as well as a mature neuron.

RNA 105

RNA Treatment Research Disease 105