ASPET

JUNE 10, 2024

We previously reported that short-term treatment with SLO at relatively high concentrations (10-1000 ng/mL) diminished acetylcholine-induced, endothelial-dependent relaxation in a concentration-dependent manner. In this study, treatment of rat aorta with endothelium with SLO (0.1-10 In vivo SLO treatment (46.8

Treatment 100

Treatment Production 100

Drug Target Review

JANUARY 15, 2024

Could you provide insights into the driving factors behind exploring novel treatments for cancer types? Additionally, in evaluating the effectiveness of our initial pipeline asset, we sought tumours suitable for intratumoural injection that present surface-accessible lesions. What aspects prompted this research direction?

Treatment 105

Treatment Immune Response Therapies Clinical Trials 105

Chemical Biology and Drug Design

SEPTEMBER 20, 2023

The combined treatment successfully enhanced cisplatin cytotoxicity and helped to overcome cisplatin resistance in CR-Caov3 cells. Most patients experience recurrence and succumb eventually to resistant disease, underscoring the need for an alternative treatment option.

Treatment 190

Treatment Disease Research 190

Drug Target Review

DECEMBER 13, 2024

These types differ in their etiology, natural history, and present distinct challenges in disease management. 2 Unmet needs in lung cancer treatment Recent decades have seen significant advancements in lung cancer treatment, especially with the introduction of targeted therapies and immunotherapies, which have notably improved survival rates.

Therapies 98

Therapies Treatment Clinical Trials Drugs 98

Covalent Modifiers

JULY 25, 2024

Our results highlight advantages in developing covalent inhibitors, such as USP30-I-1, for targeting USP30 as treatment of disorders with impaired mitophagy.

Biochemical Assays 182

Biochemical Assays Small Molecule Treatment Disease 182

SCIENMAG: Medicine & Health

JUNE 26, 2023

CDT, Tuesday, June 27, 2023)—By monitoring early-response biomarkers in men undergoing 177Lu-PSMA prostate cancer treatment, physicians can personalize dosing intervals, significantly improving patient outcomes.

Treatment 82

Treatment 82

Drug Target Review

MARCH 7, 2024

1 Although pancreatic cancer is rarer than the abovementioned cancers, it claims over 50,000 lives each year in the United States because of a lack of effective treatments. Since then, two therapies have been approved for use in lung and breast cancer but it did not advance pancreatic cancer treatment.

Treatment 98

Treatment Therapies Clinical Trials Research 98

Chemical Biology and Drug Design

FEBRUARY 25, 2025

A combination of network pharmacology and invitro validation was used to reveal the potential targets and molecular mechanisms of resveratrol for CRS treatment. Together, the present study systematically clarified the possible mechanisms of RES in the treatment of CRS and provided new ideas for the drug research of this disease.

Treatment 100

Treatment Disease Drug Research Research 100

ASPET

JUNE 4, 2024

The goal of the present study was to determine the antiarthritic potential of the minor cannabinoid 8 -THC using the collagen-induced arthritis (CIA) mouse model. The 8 -THC treatment (30 mg/kg) reduced paw swelling and qualitative signs of arthritis.

Treatment 186

Treatment Disease Production 186

Drug Target Review

OCTOBER 25, 2023

Their findings may result in new treatments for reproductive conditions. He stated that this could inform new treatments for reproductive conditions like recurrent pregnancy loss and preeclampsia. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester.

Treatment 105

Treatment Virus Research Science 105

Chemical Biology and Drug Design

OCTOBER 25, 2023

UAN rats possessed prominent levels of serum creatinine, UA, cys-C, and NGAL, which all reduced after hispidulin treatment in a dose-dependent manner. HE staining determined the improvement of kidney injury after treatment, which was comparable to the efficacy of febuxostat.

Treatment 100

Treatment Drugs Research 100

Chemical Biology and Drug Design

FEBRUARY 2, 2024

Abstract Existing chemotherapy for neglected tropical diseases (NTDs) can often be toxic and ineffective, highlighting the necessity for new treatments. Their use in combination therapy decreases the concentration of the reference drug used. Terpenes are secondary metabolites with pharmacological potential.

Treatment 100

Treatment Disease Immune Response Therapies 100

SCIENMAG: Medicine & Health

JUNE 8, 2023

ECU Centre for Precision Health Clinical Professor Adnan Khattak presented the trial’s latest results at the 2023 American Society of Oncology (ASCO) congress in Chicago this week, the biggest […]

Treatment 90

Treatment Vaccine Trials Research 90

PLOS: DNA Science

MARCH 28, 2024

FDA classifies it as a “nonsteroidal treatment” – not a gene therapy, but it affects gene expression. A Scant Protein with Outsize Importance Slowing the muscle decline of DMD presents two huge challenges: the ubiquity of muscle and a giant gene. The gene presents a complex landscape. million DNA bases.

FDA Approval 97

FDA Approval Treatment FDA DNA 97

ASPET

OCTOBER 23, 2024

The delayed nature of cerebral ischemia secondary to SAH-related vasculopathy presents a window of opportunity for the evaluation of well-tolerated neuroprotective agents administered soon after ictus. Based on allometric scaling of both toxicological and efficacy data, the therapeutic margin in man should be at least 2.

Clinical Development 100

Clinical Development Treatment Pharmacokinetics Drugs 100

Drug Target Review

JULY 12, 2023

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). How does the DCI mechanism compare to the design of other drugs for cancer treatment?

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

Codon

NOVEMBER 3, 2024

In the 1924 novel, The Magic Mountain , Thomas Mann describes a sanatorium patient named Anton Ferge as he undergoes a painful tuberculosis (TB) treatment. tuberculosis ’ cellular architecture, however, presents an additional challenge for scientists developing new antibiotics. million people every year. tuberculosis.

Vaccine 98

Vaccine Trials Therapies Treatment 98

Chemical Biology and Drug Design

DECEMBER 15, 2023

Due to the complex pathological processes underlying neurodegeneration, at present, there is no viable therapy available for neurodegenerative disorders. Abstract Neurodegenerative disorders, which affect millions worldwide, are marked by a steady decline of neurons that are selectively susceptible.

Disease 189

Disease Therapies Treatment Research 189

Covalent Modifiers

AUGUST 8, 2023

3c05899 Owing to their remarkable pharmaceutical properties compared to those of noncovalent inhibitors, the development of targeted covalent inhibitors (TCIs) has emerged as a powerful method for cancer treatment. Herein, we present the first compound capable of covalently engaging both K-Ras(G12D) and K-Ras(G12C) mutants.

Treatment 130

Treatment Pharmaceuticals Drugs 130

Covalent Modifiers

DECEMBER 22, 2023

APOD53 forms a covalent adduct with a reactive cysteine residue present in the TRF2TRFH domain and induces phenotypes consistent with TRF2TRFH domain mutants. These include induction of a telomeric DNA damage response, increased telomeric replication stress, and impaired recruitment of RTEL1 and SLX4 to telomeres.

DNA 162

DNA Regulations Treatment 162

National Institute on Drug Abuse: Nora's Blog

MARCH 6, 2025

Advancing reduction of drug use as an endpoint in addiction treatment trials astewart Thu, 03/06/2025 - 09:59 Nora's Blog March 18, 2025 Image Getty Images/ SolStock This blog was also published in the American Society of Addiction Medicine (ASAM) Weekly on March 18, 2025.&

Treatment 68

Treatment Trials Clinical Trials Drugs 68

SCIENMAG: Medicine & Health

MARCH 20, 2024

Milan, Italy: Using a combined scanning technique on patients with early-stage breast cancer improved treatment in almost three out of ten cases in a trial presented at the 14th European Breast Cancer Conference today (Thursday). [1]

Treatment 68

Treatment Doctors Trials 68

ASPET

SEPTEMBER 22, 2023

These results suggest that brain damage can be long-lasting or permanent if nerve agent-induced SE in infant victims is treated with midazolam at a delayed timepoint after SE onset, while antiglutamatergic treatment with tezampanel and caramiphen provide significant neuroprotection.

Treatment 100

Treatment FDA Drugs 100

Drug Patent Watch

DECEMBER 9, 2024

” – Dr. Vandana Shiva, Environmental Activist and Author Navigating the Patent Landscape for Natural Products Patenting natural products presents unique challenges. Taxol: From Pacific Yew to Cancer Treatment Taxol (paclitaxel), a widely used cancer drug, was originally isolated from the bark of the Pacific yew tree.

Drugs 97

Drugs Drug Development Pharmaceuticals Production 97

DrugBank

MARCH 12, 2025

  The Expanding Role of mRNA in Cancer Therapy One of the most exciting applications of mRNA therapeutics lies in cancer treatment, where leveraging the immune system to target tumors offers a novel approach. Once delivered into the body, the mRNA instructs cells to produce these antigens, which are then presented to the immune system.

Vaccine 52

Vaccine Treatment Clinical Trials Therapies 52

Drug Target Review

MAY 23, 2024

What is the main advantage of TriTCE Co-Stim over conventional CD3-engaging bispecific T cell engagers (TCEs) in the treatment of solid tumours? These challenges are related in part to limited intratumoural T cell availability and poor T cell function (T cell anergy) commonly present in solid tumours. The lead CLDN18.2

Treatment 69

Treatment Engineering Therapies Research 69

ASPET

JULY 13, 2023

Significance Statement Results presented in this paper, for the first time, implicate the dynamin DNM2 in ocular surface epitheliopathy. We conclude that exposure to tBHP or nitrogen mustard, two different oxidative stress agents, cause corneal epitheliopathy via different pathological pathways.

Small Molecule 100

Small Molecule Treatment 100

Conversations in Drug Development Trends

NOVEMBER 21, 2023

Despite significant progress, there are more than 6,500 rare diseases without a single approved treatment. There are so many patients suffering from diseases that have no treatments. We are committed to supporting reimbursement and exploring ways to increase patient access to treatments. “We

Disease 78

Disease Treatment Clinical Trials Clinical Development 78

Conversations in Drug Development Trends

NOVEMBER 12, 2024

Cell therapy can be effective, but clinically testing the treatment presents several logistical challenges that require early planning and rigorous management by specialized and experienced teams throughout the clinical trial timeline.

Therapies 72

Therapies Clinical Supply Clinical Trials Trials 72

ASPET

NOVEMBER 17, 2023

Ketamine is a new, potent and rapid-acting antidepressant approved for therapy of treatment-resistant depression, which has a different mechanism of action than currently-available antidepressant therapies. It owes its uniquely potent antidepressant properties to a complex mechanism of action, which currently remains unclear.

Therapies 100

Therapies Treatment Drugs 100

PPD

MARCH 11, 2025

Developing treatments for individuals living with rare diseases is critical, but orphan drug development is laden with unique obstacles that necessitate innovative, multifaceted approaches. This limited pool poses significant barriers to conducting statistically significant studies and validating the efficacy and safety of new treatments.

Drug Development 52

Drug Development Clinical Trials Disease Trials 52

SCIENMAG: Medicine & Health

MARCH 28, 2024

DETROIT – A groundbreaking study published in the journal iScience presents crucial insights into the ocular effects of Zika virus infection during pregnancy and offers promising avenues for therapeutic intervention.

Virus 67

Virus Treatment Research 67

Chemical Biology and Drug Design

APRIL 3, 2024

The present review explores the intricate relationship between autophagy and proteostasis in the pathogenesis of neurodegenerative diseases along with the therapeutic interventions to mitigate the same. Abstract Neurodegenerative disorders are devastating disorders characterized by gradual loss of neurons and cognition or mobility impairment.

Disease 100

Disease Treatment Research 100

Elrig

MARCH 25, 2025

In addition, the conference comprises poster presentations, networking sessions, a vendor exhibition and a tour of AstraZenecas R&D centre. Prof Johnsons keynote presentation on day one will focus on Genomics-powered lncRNA therapeutics for oncology.

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Chemical Biology and Drug Design

MAY 11, 2023

Abstract Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects. The figure depicts the neuroprotective role of crocin in Parkinson's disease.

Disease 100

Disease Research Clinical Trials Treatment 100

ASPET

SEPTEMBER 20, 2024

The present studies evaluated the reinforcing effects of both compounds in monkeys under several conditions. Recently, several modafinil analogues reduced cocaine SA in rats and monkeys, including JJC8-088, characterized as "cocaine like" in rats, and JJC8-091, characterized as "atypical" and not SA by rats. mg/kg/injection), and JJC8-091 (0.1-3.0

FDA Approval 100

FDA Approval Treatment FDA Drugs 100

Drug Target Review

JANUARY 15, 2024

Monoclonal antibodies (mAbs) targeting tumour-specific antigens play an essential role in the treatment of many cancers. An important limitation of antibodies against tumour antigens is that these agents direct responses to molecular targets present on the surface of the cell.

Engineering 110

Engineering DNA Virus Immune Response 110