Drug Hunter

JUNE 5, 2023

Interestingly, among the six case studies, none use the well-known Hoveyda-Grubbs II (HG-II) catalyst in the largest scale synthesis disclosed, though several employ HG-II derivatives, highlighting the rapid evolution of catalytic methods and distinct considerations for process chemistry. Gonzalez-Bobes, F. 2023 , 66 , (8), 5377-5396.

Process Chemistry 206

Process Chemistry Drugs Production Clinical Development 206

Fierce BioTech

JULY 27, 2023

Process Chemistry Unleashed: A 'Fit-for-Purpose' Approach to Accelerate IND Filing pesurya Thu, 07/27/2023 - 11:27 Tue, 09/05/2023 - 10:00 Resource Type Webinar Qixuan Lu Duration 60 Minutes Process chemistry plays a pivotal role in various stages of the pharmaceutical R&D cycle.

Process Chemistry 52

Process Chemistry Compliance FDA Drug Development 52

Sygnature Discovery

JANUARY 26, 2024

For instance, small scale batches from chiral SFC might be amorphous and dissolve readily, but process chemistry and scale-up could produce a crystalline form, affecting solubility and in vivo performance. Understanding the solid form properties of a material can significantly impact other studies.

Process Chemistry 52

Process Chemistry 52

Sygnature Discovery

MAY 17, 2024

For instance, small scale batches from chiral SFC might be amorphous and dissolve readily, but process chemistry and scale-up could produce a crystalline form, affecting solubility and in vivo performance. Understanding the solid form properties of a material can significantly impact other studies.

Process Chemistry 52

Process Chemistry 52

Sygnature Discovery

JANUARY 26, 2024

Working closely with our colleagues in Process Chemistry and Scale-Up, Drug Metabolism and Pharmacokinetics (DMPK), Pharmacology, and Separation Science, we can apply the right tools to solve the most complex challenges in your project. This approach helps to overcome even the most complex bioavailability or stability challenges.

Process Chemistry 52

Process Chemistry Pharmacokinetics Clinical Development Laboratories 52

Metabolite Tales Blog

JULY 5, 2023

Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. [link] [3] Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles. Balazs et al.,

Drugs 52

Drugs Metabolic Stability FDA Approval Treatment 52

Metabolite Tales Blog

JULY 5, 2023

Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. [link] [3] Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles. Balazs et al.,

Metabolic Stability 52

Metabolic Stability Drugs FDA Approval Treatment 52