The Open Targets Blog

SEPTEMBER 21, 2023

This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way. Process chemistry is incredibly multidisciplinary: in addition to chemists, you need analytical teams to make sure everything is 99.9%

Organic Chemistry 82

Organic Chemistry Process Chemistry Small Molecule Science 82

Metabolite Tales Blog

JULY 5, 2023

A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Figure 2 Human metabolism of glecaprevir Involvement of gut bacteria Grazoprevir (MK5172) is also used as part of combination therapy to treat chronic hepatitis C. Journal of Medicinal Chemistry 62 (21), 9418-9437.

Drugs 52

Drugs Metabolic Stability FDA Approval Treatment 52

Metabolite Tales Blog

JULY 5, 2023

A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Figure 2 Human metabolism of glecaprevir Involvement of gut bacteria Grazoprevir (MK5172) is also used as part of combination therapy to treat chronic hepatitis C. Journal of Medicinal Chemistry 62 (21), 9418-9437.

Metabolic Stability 52

Metabolic Stability Drugs FDA Approval Treatment 52

Drug Target Review

MARCH 8, 2025

Dr Lopa Bakrania brings over 18 years of experience in pharmaceutical process chemistry and CMC regulatory affairs. As Executive Director of CMC Regulatory Affairs at Biohaven , she leads efforts to develop innovative therapies from the clinic to market approval. She is the head of CMC regulatory affairs at Biohaven.

Science 59

Science Organic Chemistry Process Chemistry Therapies 59