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Metabolism of macrocyclic drugs

Metabolite Tales Blog

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Journal of Medicinal Chemistry 62 (21), 9418-9437. Balazs et al., Drug Hunter article, June 2023. 20 (March 20, 2014).

Drugs 52
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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Journal of Medicinal Chemistry 62 (21), 9418-9437. Balazs et al., Drug Hunter article, June 2023. 20 (March 20, 2014).

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Welcome to new Director David Hulcoop

The Open Targets Blog

This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way. Process chemistry is incredibly multidisciplinary: in addition to chemists, you need analytical teams to make sure everything is 99.9%