Process Chemistry Treatment Trials 
Metabolite Tales Blog
JULY 5, 2023
Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders. Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. It’s metabolised to 3 main metabolites by CYP3A with potential additional involvement of CYP2C8 and CYP2C19.
Metabolite Tales Blog
JULY 5, 2023
Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders. Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. It’s metabolised to 3 main metabolites by CYP3A with potential additional involvement of CYP2C8 and CYP2C19.
The Open Targets Blog
SEPTEMBER 21, 2023
This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way. Process chemistry is incredibly multidisciplinary: in addition to chemists, you need analytical teams to make sure everything is 99.9%
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