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Metabolism of macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders. A multitude of macrocyclic antiviral drugs The antiviral drug simeprevir (TMC435) was approved for the treatment of chronic hepatitis C in 2013 but has since been discontinued in favour of more effective drugs.

Drugs 52
Drugs Metabolic Stability FDA Approval Treatment 52
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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders. A multitude of macrocyclic antiviral drugs The antiviral drug simeprevir (TMC435) was approved for the treatment of chronic hepatitis C in 2013 but has since been discontinued in favour of more effective drugs.

Metabolic Stability 52
Metabolic Stability Drugs FDA Approval Treatment 52
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