Chemical Biology and Drug Design

AUGUST 23, 2023

We hypothesized that ligustrazine could protect liver by decreasing the inflammation response, protein production, and apoptosis in THS rats. The protein expressions were detected via western blot. It also decreases the platelets' bioactivity and reduces reactive oxygen species formation.

Protein Expression 100

Protein Expression Protein Production Treatment Production 100

Broad Institute

JUNE 29, 2023

They found key differences between where mRNAs are made and where the corresponding proteins are being translated in several cell types, suggesting that cells are regulating translation in ways that existing transcriptomic methods, which analyze mRNA production, aren’t able to detect. By Sarah C.P. and Virginia W.

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Protein Production RNA Regulations Science 105

Drug Target Review

OCTOBER 10, 2023

The focus of this new centre will be on the development and production of research- and diagnostic-grade proteins and antibodies utilising mammalian cells, which possess the unique machinery to yield natural, in vivo -like products with high bioactivity,” stated Dr Rob Burgess, Chief Business Officer for Sino Biological.

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Protein Production Science Production Research 98

Drug Target Review

MARCH 15, 2024

Advancements in cell line development (CLD), including screening and selection of final clones, scale up, automation and digitalisation have enabled precision and enhanced productivity. Efforts have focused on Chinese hamster ovary (CHO) cell line improvements since it is a commonly used host for the expression of therapeutic proteins.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

FDA Law Blog: Biosimilars

JULY 11, 2023

Koblitz — One of the most important questions FDA has to answer is whether a given product is appropriately characterized as a drug, biologic, device, food, cosmetic, or something entirely different. As we have explained before , that distinction is critical to assigning a particular product to the appropriate regulatory scheme.

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FDA Regulations Production Small Molecule 95

FDA Law Blog: Biosimilars

MARCH 5, 2024

Gaulkin & Riëtte van Laack — As readers of this blog know, there is a lot of contention about the naming of alternative protein products (APPs), including both plant-based and cell-cultured alternatives for (traditional) animal products. We’ve previously blogged about this ongoing battle here , here , here , and here.

Protein Production 59

Protein Production Production DNA Regulations 59

Agency IQ

APRIL 12, 2024

Draft guidance on potency assays for CGT products garners extensive stakeholder input Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue. How does “potency” apply to cell and gene therapy (CGT) products?

Production 40

Production FDA Therapies Biochemical Assays 40

The Pharma Data

JANUARY 16, 2021

Etta Biotech”), to set up a high titer transient protein expression platform for high quality protein production using JS Bio’s transient transfection media. JS Bio becomes the exclusive cell culture supplier for Etta Biotech’s transient transfection high titer protein expression platform. JS Bio’s parent company.

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Protein Expression Protein Production Production Drug Development 52

Drug Target Review

JULY 5, 2023

A good introduction to the use of CHO cells for biotherapeutics production can be found in an article commemorating the 20th anniversary of the approval of a product produced using CHO cells. Over time, there may also be a cost benefit with developing a proprietary system if there is a pipeline of multiple products to produce.

Engineering 105

Engineering DNA Laboratories Production 105

Codon

MARCH 24, 2024

The market for semaglutide-based products is projected to swell to $71B in less than a decade. All of this future value, of course, relies upon these companies actually making enough of their product to meet the growing demand. In November, Novo Nordisk invested $6B in additional production capacity.

Engineering 84

Engineering Vaccine Production RNA 84

Sygnature Discovery

SEPTEMBER 12, 2024

Protein Purification Standard chromatography methods for purification of high grade protein. In vivo biotinylation of target protein. Dedicated Membrane protein production team. Protein refolding from inclusion bodies. Low endotoxin batches. Low endotoxin batches.

Science 52

Science Protein Production RNA Packaging 52

Sygnature Discovery

SEPTEMBER 11, 2024

We’ve successfully tackled targets for: Unprecedented membrane proteins Intrinsically disordered proteins Refolding from inclusion bodies Large protein complexes Labelled proteins for NMR studies RNA structures by crystallography Across our capabilities Protein Expression & Purification Vast diversity of proteins produced.

Science 52

Science Compound Screening RNA Protein Expression 52

Sygnature Discovery

APRIL 26, 2022

Sygnature have acquired Peak Proteins Ltd. Following an extensive partnership between the two companies, this deal will enable seamless integration of protein production and related structure determination projects within Sygnature. The Peak Proteins leadership team will also remain with the business.

Fragment Screening 40

Fragment Screening Protein Production Protein Expression Production 40

Sygnature Discovery

SEPTEMBER 12, 2024

High quality protein production in-house Protein quality is the key factor for structure projects. We have extensive experience in producing difficult proteins, including membrane proteins. PANDDA analysis for rapid delivery of a hit list. Fragment analogs identified for rapid follow-up.

Fragment Screening 52

Fragment Screening RNA Protein Production DNA 52

The Pharma Data

OCTOBER 14, 2020

Premature stop codons are point mutations that disrupt protein synthesis from messenger RNA. As a consequence, patients with premature stop codon diseases have reduced or eliminated protein production from the mutation bearing allele accounting for some of the most severe phenotypes in these genetic diseases.

Pharmaceuticals 52

Pharmaceuticals RNA Small Molecule Protein Production 52

Drug Target Review

NOVEMBER 1, 2023

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. With all these diverse methods we characterise protein-ligand interactions in many ways.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

The Pharma Data

OCTOBER 18, 2021

Tofersen binds to SOD1 mRNA, allowing for its declination by RNase-H in an trouble to reduce conflation of SOD1 protein product. About Tofersen Tofersen is an antisense medicine being estimated for the implicit treatment of SOD1-ALS.

Biosimilars 40

Biosimilars Protein Production Licensing Licensing 40

The Pharma Data

DECEMBER 22, 2020

Using the obtained sequencing data, Kao Corporation was able to produce an antibody sample in one week using protein production technology such as enzymes cultivated by our technology. Comment from Fumiharu Muroga, Growth Manager at Real Tech Fund] “Proteins are an important structural component of living things.

Engineering 52

Engineering Pharmaceuticals Protein Production Drugs 52

The Pharma Data

MARCH 23, 2022

Without the stop sign, viral transcription no longer follows the correct order, which has a negative impact on viral protein production,” says Fang. “The virus hijacks this protein and makes it do something different than its normal job in cells. “We weren’t expecting to see this,” says Fang.

Virus 52

Virus Small Molecule Protein Production Research 52

Broad Institute

AUGUST 24, 2022

LIG1 ’s protein product is a critical component of lagging strand DNA synthesis that connects Okazaki fragments (small DNA segments that must be connected to complete the synthesis reaction).

DNA 52

DNA Protein Expression Treatment Protein Production 52

The Pharma Data

JANUARY 24, 2021

Elasmogen is unique in its capacity to isolate and develop soloMERs, with a multi-layered IP position covering the platform, humanisation, formats, products and process including over 25 patents granted in the US, Europe and other territories.

Research 40

Research Virus Medical Schools Protein Production 40

Codon

MARCH 20, 2023

Point-of-care peptide hormone production enabled by cell-free protein synthesis. Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. Murakami K. DeWinter MA.

Virus 52

Virus Engineering RNA Small Molecule 52

Codon

MAY 30, 2023

Biosynthesis of cannabigerol and cannabigerolic acid, the gateways to further cannabinoid production. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. He took products to market at prices people were willing to pay. Synthetic Biology. coli cells.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Biosynthesis of cannabigerol and cannabigerolic acid, the gateways to further cannabinoid production. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. He took products to market at prices people were willing to pay. Synthetic Biology. coli cells.

DNA 52

DNA RNA Engineering Vaccine 52

Dark Matter Blog

JULY 16, 2021

At Biogen, my group’s work covered a range of technology development areas including protein production in mammalian cells, intracellular protein delivery (our work on HIV Tat started the field of cell-penetrating peptides) and novel gene delivery vehicles, as well as biological drug discovery and development.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Coincidence? I’ve never thought so.

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Virus RNA DNA Science 52

The Pharma Data

JANUARY 13, 2021

The deal will provide Biogen the rights to use the technology across their portfolio of gene therapy products. This product complements Cellectis’ portfolio of technologies involved in manufacturing allogeneic CAR T-cells. Aker BioMarine will supply the company with all its LPC product needs.

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Licensing Licensing Clinical Trials Vaccine 52

The Pharma Data

DECEMBER 3, 2020

These forward-looking statements may be accompanied by such words as “aim,” “anticipate,” “believe,” “could,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “possible,” “will,” “would,” and other words and terms of similar meaning.

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Clinical Trials Protein Expression Pharmacokinetics Trials 52

Drug Target Review

DECEMBER 10, 2024

Today, I lead an incredible team of engineers, leveraging my natural talents alongside my education in our pursuit of making bio-produced products more accessible. The main challenge right now is cost; we need to find ways to produce these products affordably enough for widespread adoption.

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Protein Production Production Engineering Vaccine 98

PLOS: DNA Science

AUGUST 8, 2024

Imprinting disorders can also result from differences between parental genders in gene expression – that is, protein production from the encoded information. In Prader-Willi and Angelman syndromes, a tiny section of the same chromosome is absent.

Small Molecule 52

Small Molecule DNA Drugs Protein Production 52

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. Nature Biotechnology (2009). Nature (2017).

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DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. Nature Biotechnology (2009). Nature (2017).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52