The Pharma Data

OCTOBER 14, 2020

is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates (designed to be eukaryotic ribosomal selective glycosides) that are formulated to treat rare and ultra-rare premature stop codon diseases. Premature stop codons are point mutations that disrupt protein synthesis from messenger RNA.

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Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. I wanted to use molecular biology to create drugs.

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The Pharma Data

MARCH 23, 2022

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. “The virus hijacks this protein and makes it do something different than its normal job in cells.

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Virus Small Molecule Protein Production Research 52

Broad Institute

AUGUST 24, 2022

Data from standard DNA and RNA sequencing approaches were integrated with mass spectrometry-based proteomics and phosphoproteomic analyses to derive more complete molecular portraits of treatment-responsive versus treatment-resistant tumors.

DNA 52

DNA Protein Expression Treatment Protein Production 52

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

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RNA Production Molecular Biology Laboratories 84

PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Coincidence? I’ve never thought so. b) in an abandoned mine shaft?

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Virus RNA DNA Science 52

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

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Engineering Protein Production RNA Vaccine 140

Codon

MARCH 20, 2023

Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Point-of-care peptide hormone production enabled by cell-free protein synthesis. Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment. Szymczak P. Nature Communications.

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Virus Engineering RNA Small Molecule 52

Codon

MARCH 24, 2024

The market for semaglutide-based products is projected to swell to $71B in less than a decade. All of this future value, of course, relies upon these companies actually making enough of their product to meet the growing demand. In November, Novo Nordisk invested $6B in additional production capacity.

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Engineering Vaccine Production RNA 87

Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods. coli cells.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods. coli cells.

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DNA RNA Engineering Vaccine 52

Broad Institute

FEBRUARY 5, 2025

PELO encodes a protein responsible for restarting ribosomes when they stall on defective mRNA sequences during protein production. The FOCAD and TTC37 proteins are part of and help stabilize an assembly called the superkiller complex, which extracts RNA from stalled ribosomes.

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Protein Production DNA Drugs RNA 100

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Nature Biotechnology (2009). Nature (2017). & Ueda T.

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DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Nature Biotechnology (2009). Nature (2017). & Ueda T.

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DNA Cell Biology Engineering Molecular Biology 52