Drug Target Review

MARCH 15, 2024

Advancements in cell line development (CLD), including screening and selection of final clones, scale up, automation and digitalisation have enabled precision and enhanced productivity. Efforts have focused on Chinese hamster ovary (CHO) cell line improvements since it is a commonly used host for the expression of therapeutic proteins.

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Engineering Molecular Biology Protein Expression Medical Schools 105

Drug Target Review

NOVEMBER 1, 2023

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. With all these diverse methods we characterise protein-ligand interactions in many ways. You need to be resilient because science is difficult and things will fail.

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Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Codon

MARCH 24, 2024

The market for semaglutide-based products is projected to swell to $71B in less than a decade. All of this future value, of course, relies upon these companies actually making enough of their product to meet the growing demand. In November, Novo Nordisk invested $6B in additional production capacity.

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Engineering Vaccine Production RNA 87

Codon

MARCH 20, 2023

. 🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Evolutionary-scale prediction of atomic-level protein structure with a language model. DeepBindGCN: Integrating molecular vector representation with graph convolutional neural networks for accurate protein-ligand interaction prediction.

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Virus Engineering RNA DNA 52

The Pharma Data

DECEMBER 22, 2020

Comment from Mikihiko Shinozaki, Vice-Director of the Life Sciences Division at Mitsubishi UFJ Capital] “I am pleased that the series A round ended up as a success. Comment from Fumiharu Muroga, Growth Manager at Real Tech Fund] “Proteins are an important structural component of living things.

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Engineering Pharmaceuticals Drugs Protein Production 52

PLOS: DNA Science

JUNE 13, 2024

Ruling Out Alternate Explanations Requires Logic and Science Soon after Fauci’s grilling, Alina Chan, a molecular biologist at the Broad Institute of MIT and Harvard, succinctly explained the converging evidence in a compelling Opinion piece in the June 9 New York Times. I tuned much of that out, focusing on clues in the science. (I

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Virus RNA DNA Science 52

Codon

MAY 30, 2023

Biosynthesis of cannabigerol and cannabigerolic acid, the gateways to further cannabinoid production. Science Advances. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Science Advances. Science Advances. Synthetic Biology. coli cells.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Biosynthesis of cannabigerol and cannabigerolic acid, the gateways to further cannabinoid production. Science Advances. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Science Advances. Science Advances. Synthetic Biology. coli cells.

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DNA RNA Engineering Vaccine 52

Dark Matter Blog

JULY 16, 2021

At Biogen, my group’s work covered a range of technology development areas including protein production in mammalian cells, intracellular protein delivery (our work on HIV Tat started the field of cell-penetrating peptides) and novel gene delivery vehicles, as well as biological drug discovery and development.

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Small Molecule RNA Clinical Trials DNA 52

The Pharma Data

JANUARY 13, 2021

The deal will provide Biogen the rights to use the technology across their portfolio of gene therapy products. This product complements Cellectis’ portfolio of technologies involved in manufacturing allogeneic CAR T-cells. Few details of the deal were disclosed in the announcement.

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Licensing Licensing Clinical Trials Trials 52

Drug Target Review

DECEMBER 10, 2024

Today, I lead an incredible team of engineers, leveraging my natural talents alongside my education in our pursuit of making bio-produced products more accessible. When I said I did, he replied, “well, science is hard.” Additionally, I hope to see our approach to automated, small-footprint manufacturing adopted globally.

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Protein Production Production Engineering Vaccine 98

PLOS: DNA Science

AUGUST 8, 2024

Imprinting disorders can also result from differences between parental genders in gene expression – that is, protein production from the encoded information. The post An “Unsilencer” Drug May Treat Angelman Syndrome – Someday appeared first on DNA Science. ” And that’s good news indeed!

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Small Molecule DNA Drugs Protein Production 52

BMG Labtech

FEBRUARY 24, 2025

In this context, microplate readers also provide an important resource to perform complementary biological assays that build a wider picture of the levels of different biological molecules that are involved in the highly interconnected processes that lead to specific protein nitration.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Science (2018). Science (2017). Science (2010). Science (2016). Science (2023). Link Biocontainment of genetically modified organisms by synthetic protein design , by Mandell D.J. Politics and the Life Sciences (2009).

DNA 96

DNA Cell Biology Molecular Biology Engineering 96

Codon

AUGUST 10, 2023

Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Science (2018). Science (2017). Science (2010). Science (2016). Science (2023). Link Biocontainment of genetically modified organisms by synthetic protein design , by Mandell D.J. Politics and the Life Sciences (2009).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52