addgene Blog

JULY 25, 2023

For safety and production reasons, multiple plasmids with many components are used to package lab grown viruses. So, if you’ve ever wondered what goes into ‘making virus’ or what gag and pol stand for, we demystify all components of viral vectors here! It can be intimidating at first to look at so many plasmid maps and protocols!

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The Pharma Data

JANUARY 17, 2021

Environmental Protection Agency (EPA) for use on hard non-porous surfaces against the SARS-CoV-2 virus that causes COVID-19. Official tests submitted to the EPA prove that Thymox disinfectant spray kills SARS-CoV-2 virus (the virus that causes COVID-19) in only 55 seconds on hard surfaces. ” continued Auray.

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The Pharma Data

MARCH 23, 2022

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.

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Drug Discovery Today

DECEMBER 5, 2020

OVO’s technology allows manufacturers of both established and novel viral vaccines and gene therapies to maximise the production of the target virus used to produce each therapy. The technology can be applied to any virus that is grown to produce a vaccine or therapy.

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addgene Blog

AUGUST 15, 2024

What do a viral vector production facility, food allergy testing lab, and the grad student down the hall from you have in common? All of them rely on standard curves in their day-to-day work.

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Advarra

AUGUST 31, 2022

These injuries are often associated with occupational exposure to human bloodborne pathogens such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). The post Safe Sharps Handling When Dispensing Investigational Products appeared first on Advarra.

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NIOSH Science Blog: Drugs

FEBRUARY 3, 2023

Air filtration units were widely used during large wildfire outbreaks in the western United States,[1] and their use surged nationwide during the COVID-19 pandemic as a way to reduce exposure to aerosols containing the SARS-CoV-2 virus.

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The Pharma Data

MAY 26, 2023

Recognizing existing national capacities for the prevention and response to epidemics and pandemics while reflecting on recent COVID-19 experiences provides insights on how countries can further strengthen pandemic preparedness and response capacities.

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The Pharma Data

NOVEMBER 27, 2020

UK firm develops solution for identifying whether patients are actually infectious from a virus or not. Iceni Diagnostics has revealed it is developing a new technology that can disclose if patients are actually infectious with a live virus or not. Save your seat at IDBS’s upcoming webinar. Source link.

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Codon

OCTOBER 13, 2024

.” From their first intrepid steps into the fields, GM crops have become a scapegoat for distrust in science and its overextension into formerly “unadulterated” products. Genetic engineering in the medicine cabinet is one thing; allowing it at the dinner table is another. Yields were devastated.

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Engineering Virus Production DNA 101

Drug Target Review

APRIL 5, 2024

However, there is significant variability within the various CHO cell lines, and CDMOs often have differing levels of success in optimising their cells for protein production. Skilled CDMOs can also locate or create favourable genomic microenvironments where transcription factors are efficiently recruited, further boosting protein production.

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Alta Sciences

SEPTEMBER 20, 2023

NASDAQ:VRPX) (“Virpax”), a company specializing in developing non-addictive products for pain management, PTSD, central nervous system (CNS) disorders, and viral barrier indications, to conduct nonclinical studies in support of their development of quaternary ammonium palmitoyl glycol chitosan (GCPQ, under the trade name of AnQlar™).

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The Pharma Data

MARCH 2, 2021

Bayer will introduce Vynyty Citrus ® , its latest biological and pheromone-based crop protection product to control pests on citrus farms during the International Symposium on Horticulture in Europe – SHE2021 , March 8-11. Promising results were achieved in tomato production in Spain. More than 500 are expected to attend.

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Agency IQ

SEPTEMBER 6, 2023

EPA issues guidance for disinfectant product claims used on soft surface textiles in non-residential settings The Environmental Protection Agency has issued guidance and test methods to support disinfectant efficacy claims for products intended for use on soft surface textiles in clinical and institutional (non-residential) settings.

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Broad Institute

MAY 16, 2024

The team said that the new AAVs are ideal for gene therapy because they target a human protein and have similar production and purification yields as AAV9 using scalable manufacturing methods. Gene therapy could potentially treat a range of severe genetic brain disorders, which currently have no cures and few treatment options.

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PLOS: DNA Science

FEBRUARY 8, 2024

They write: “Genome engineering of probiotics, including the editing of the genome to introduce, remove, or modify phenotypes, will improve their tolerance to stress during food production, promote their survival in the gastrointestinal tract, or enhance their probiotic function. But will it, can it, improve upon nature?

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Drug Target Review

DECEMBER 5, 2024

However, the production process of fully assembled rAAV particles generates by-products and requires thorough characterisation to ensure efficacy while minimising the potential for immunogenicity and off-target effects. Therefore, vectors based on these serotypes may enable targeted gene delivery and optimal transduction efficiency.

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FDA Law Blog: Drug Discovery

DECEMBER 7, 2022

This product was developed by uniQure prior to being licensed to CSL Behring. We know, for example, the use of viral vectors results in antibody production that could inhibit future administration of gene therapies using the same or similar viruses, which will inform treatment decisions by patients with their doctors.

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The Pharma Data

OCTOBER 28, 2020

In the overall patient group with detectable virus at baseline, the average daily reduction in viral load through day 7 was a 0.36 About REGN-COV2 REGN-COV2 is a combination of two monoclonal antibodies (REGN10933 and REGN10987) and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19.

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Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

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The Pharma Data

FEBRUARY 22, 2021

State Premier of North Rhine-Westphalia Armin Laschet and Birgitta Radermacher, President of Duesseldorf Administrative District, today visited Bayer AG’s research and production site in Wuppertal to gain an insight into the planned vaccine production there. Effective vaccines are our best weapon to combat the pandemic. About Bayer.

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Agency IQ

JULY 26, 2024

FDA finalizes guidance on electronic submissions for OTC products FDA has fulfilled its commitment under the Over-the-Counter Monograph Drug User Fee (OMUFA) program to issue final guidance on how sponsors can electronically submit monographs and other documents. These products are regulated differently from traditional prescription drugs.

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Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. These are synthetic, not the live virus, so do not pose a risk of infection.

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The Pharma Data

MARCH 21, 2022

Food and Drug Administration is announcing a virtual meeting of its Vaccines and Related Biological Products Advisory Committee (VRBPAC) on Wed., No vote is planned at this meeting and there will not be any discussion of any product-specific applications. director of the FDA’s Center for Biologics Evaluation and Research.

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The Pharma Data

DECEMBER 14, 2020

. Product type: Nucleic acid testing (NAT) technologies that use real-time polymerase chain reaction (RT-PCR) for detection of SARS-CoV-2. Purpose of this notice : To ensure users of certain nucleic acid testing (NAT) technologies are aware of certain aspects of the instructions for use (IFU) for all products.

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The Pharma Data

MAY 5, 2022

In animal studies that mimic human exposures, an investigational COVID vaccine designed to be taken orally not only protects the host, but also decreases the airborne spread of the virus to other close contacts. Because of this, they did not shed as much virus through normal airborne exposures. Langel, Ph.D.,

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PerkinElmer

JULY 13, 2020

The complex relationship between a virus and its host is one of the hottest topics in science right now, and has been given considerable attention in recent weeks as a result of the race to understand the virus that causes COVID-19 and its potential vulnerabilities.

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Drug Target Review

APRIL 17, 2024

HLA-II presents peptides to CD4 T cells thought to be important for indirectly helping immune responses and facilitating antibody production. HLA-I molecules present peptides to CD8 T cells and are thought to be responsible for direct recognition and killing of cells with foreign viruses, bacteria, or oncogenic cancer cells.

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The Pharma Data

DECEMBER 21, 2020

(Nasdaq:BCRX) today announced that data from part 1 of a clinical trial of its broad-spectrum antiviral, galidesivir, showed that galidesivir was safe and generally well tolerated in patients infected with SARS-CoV-2, the virus that causes COVID-19. It is in advanced development for the treatment of Marburg virus disease.

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The Pharma Data

JANUARY 31, 2021

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. Trimer-Tag© is an innovative drug development platform which allows the production of novel, covalently-trimerized fusion proteins. About Dynavax. About GlaxoSmithKline.

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The Pharma Data

OCTOBER 30, 2020

About REGN-COV2 REGN-COV2 is a combination of two monoclonal antibodies (REGN10933 and REGN10987) and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19.

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Advarra

AUGUST 8, 2023

As of June 2023, 416 Phase III studies are listed, representing a growing pipeline of gene therapy products preparing to undergo consideration for FDA approval. Reviewing the site’s plans for disposal of the investigational product and associated biomedical waste allows the IBC to ensure environmental protection.

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The Pharma Data

AUGUST 16, 2021

Still, with the continuing threat of the Delta variant and possible emergence of other variants in the future, we must remain vigilant against this highly contagious virus,” said Albert Bourla, Chairman and Chief Executive Officer, Pfizer. We continuously strive to stay at least one step ahead of the virus.

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The Pharma Data

JANUARY 7, 2021

. “Last month, the Red Cross distributed the greatest number of convalescent plasma products than any other month during the pandemic. People who have recovered from COVID-19 may have antibodies in their plasma that could give a patient’s immune system the boost it needs to beat the virus. More Information.

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The Pharma Data

JANUARY 6, 2021

. “Last month, the Red Cross distributed the greatest number of convalescent plasma products than any other month during the pandemic. People who have recovered from COVID-19 may have antibodies in their plasma that could give a patient’s immune system the boost it needs to beat the virus. © 2021 HealthDay.

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The Pharma Data

SEPTEMBER 3, 2020

S, prevented severe clinical disease in Syrian golden hamsters, upon challenge with SARS-CoV-2, the virus that causes COVID-19 in people. Four weeks later, the animals were exposed to a high dose of SARS-CoV-2 virus. Janssen’s lead SARS-CoV-2 investigational vaccine candidate, Ad26.COV2.S, Mortalities were absent in vaccinated animals.

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The Pharma Data

NOVEMBER 13, 2020

If not enough children are immunized against polio, the weakened virus can pass between individuals and over time genetically revert to a form that can cause paralysis. If not enough children are immunized against polio, the weakened virus can pass between individuals and over time genetically revert to a form that can cause paralysis.

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