Drug Target Review

MARCH 15, 2024

As discussed above, recent advances in gene editing tools and transposon-based vectors have facilitated targeted and consistent cell line engineering for the development of protein expressing CHO cell lines. Budge JD, Knight TJ, Povey J, et al. Wright C, Alves C, Kshirsagar R, et al. Biotechnol Prog. 2017 Nov;33(6):1468-1475.

Engineering 104

Engineering Molecular Biology Protein Expression Medical Schools 104

Sygnature Discovery

APRIL 26, 2022

Sygnature have acquired Peak Proteins Ltd. Following an extensive partnership between the two companies, this deal will enable seamless integration of protein production and related structure determination projects within Sygnature. The Peak Proteins leadership team will also remain with the business.

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Fragment Screening Protein Production Protein Expression Production 52

Drug Discovery World

APRIL 30, 2024

This is essential to its use as a therapeutic agent and gives the technology a vast versatility making it suitable to treating a wide range of diseases – especially those that have high protein expression. mRNA-based approaches can produce proteins / peptides by using protein synthesis which is processed in a transfected cell 1.

Therapies 130

Therapies RNA Vaccine Small Molecule 130

Drug Discovery World

NOVEMBER 9, 2023

Thereafter, there will be the following presentations: Georgios Skretas, PhD, Director, Institute for Bio-innovation, Biomedical Sciences Research Center “Alexander Fleming;” Founder & CEO, ResQ Biotech, on: ‘Development of specialised bacterial strains for high-level production of recombinant membrane proteins’.

Engineering 130

Engineering Protein Production Therapies Science 130

Drug Discovery World

NOVEMBER 13, 2023

Sandeep Talapatra, PhD, Leader Protein Science, Protein Cell & Structural Sciences, GSK, on: ‘Enhancing success rates and throughput of protein purification for drug discovery: A medium-scale approach’. These topics include: High-throughput (HTP) protein production and AI and automation in bioprocess development.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Broad Institute

AUGUST 24, 2022

The team then conducted analyses that triangulated treatment response, chromosomal deletion or gain, and concordant decreases or increases in mRNA and protein expression. Of the hundreds of genes deleted in this location, the DNA ligase gene LIG1 was one of the mostly consistently suppressed genes at both the mRNA and protein level.

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DNA Protein Expression Treatment Protein Production 52

The Pharma Data

DECEMBER 3, 2020

protein expression by leveraging the non-mutant (wild-type) copy of the SCN1A gene to restore physiological Na V 1.1 These diseases, in which loss of approximately 50% of normal protein expression causes disease, are called autosomal dominant haploinsufficiencies. .–( BUSINESS WIRE )– Stoke Therapeutics , Inc.

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Protein Expression Clinical Trials Pharmacokinetics Trials 52

Drug Target Review

JULY 5, 2023

A good introduction to the use of CHO cells for biotherapeutics production can be found in an article commemorating the 20th anniversary of the approval of a product produced using CHO cells. 1 Another critical component in this first step is the selectable marker that will be inserted into the genome along with the GOIs.

Engineering 105

Engineering DNA Laboratories Production 105

The Pharma Data

JANUARY 13, 2021

The project aims to develop novel protein expression systems by leveraging recent advances in direct cell reprogramming to help improve the production of proteins which are not produced sufficiently well in existing expression systems. Mogrify – U.K.-based

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Licensing Licensing Clinical Trials Vaccine 52