Codon

DECEMBER 10, 2023

Natural science can learn a great deal from physics, where progress is made by proposing new models and then demonstrating their veracity through experiments. Predictive models for biology will span all scales, from individual proteins to the culture conditions in which cells grow. So why stop there?

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Broad Institute

SEPTEMBER 26, 2024

Yes, it changed me as a researcher: I gained the skills to overcome obstacles in science, plan and execute my experiments, and dive deep into the background of a project to build confidence in my research area. We hypothesized that these small molecules would similarly decrease the expression of chromatin proteins in hiPSC-derived astrocytes.

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Small Molecule Protein Expression Disease Science 52

Drug Target Review

SEPTEMBER 4, 2023

10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. He has over two years of experience in research and laboratory work. References: Antunes Luisa (2023).

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The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

SynBioBeta is one of synthetic biology’s premier events, bringing together a diverse community of thought leaders, technology innovators, engineers, scientists, and policy makers to explore the exciting new advancements that are shaping the future of science. coli extract-based cell-free protein expression assays.

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Engineering Protein Expression Research Laboratories RNA 52

The Pharma Data

MAY 2, 2022

Gilead Sciences, Inc. The target of DF7001 is 5T4, a protein expressed on cancer cells and stromal cells that support tumor growth associated with poor prognosis in several cancers, including non-small cell lung cancer (NSCLC), pancreatic cancer, breast cancer, and head and neck squamous cell carcinomas (HNSCC).

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Licensing Licensing Research Protein Expression 52

Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues. Tags Science and Health About Altasciences Weight 1

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Broad Institute

OCTOBER 4, 2023

One individual who is now a member of the US National Academy of Sciences said, ‘Marv, why in the world are you wondering how to synthesize DNA? His work demonstrates the type of technology used in the life sciences that impacts patients’ care. You’re a bright guy, why don’t you find something else to do?’

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DNA RNA Science Protein Expression 52

The Pharma Data

APRIL 26, 2022

This investigational multivalent protein subunit vaccine uses an established mechanism of action for a Lyme disease vaccine that targets the outer surface protein A (OspA) of Borrelia burgdorferi, the bacteria that cause Lyme disease. OspA is one of the most dominant surface proteins expressed by the bacteria when present in a tick.

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The Pharma Data

DECEMBER 8, 2020

December is bringing frost in the North and plenty of cold hard cash for these life sciences companies. . European venture capital firm Forbion rounded up $545 million for its fifth life sciences fund. Investments will be made in about 15 therapeutics companies, with a third created by Forbion through its “Build” opportunities.

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RNA Therapies Disease Protein Expression 52

The Pharma Data

JULY 21, 2021

This investigational multivalent protein subunit vaccine uses an established mechanism of action for a Lyme disease vaccine that targets the outer surface protein A (OspA) of Borrelia burgdorferi , the bacteria that cause Lyme disease. OspA is one of the most dominant surface proteins expressed by the bacteria when present in a tick.

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Vaccine Disease Trials Protein Expression 52

The Pharma Data

SEPTEMBER 28, 2021

In addition, results from Part 1 of Study SRP-9001-102, an ongoing, randomised, double-blind, placebo-controlled clinical test evaluating the security , efficacy, and tolerability of one dose of SRP-9001 in 41 boys with DMD, showed that the study met its primary biological endpoint of change in micro-dystrophin protein expression from baseline.

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Clinical Trials Protein Expression Therapies FDA 52

The Pharma Data

SEPTEMBER 10, 2020

Based on preclinical studies, OCREVUS binds to CD20 cell surface proteins expressed on certain B cells, but not on stem cells or plasma cells, suggesting that important functions of the immune system may be preserved. This nerve cell damage can lead to disability in people with MS. Subsequent doses are given as single 600 mg infusions.

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Treatment Disease FDA Approval Clinical Trials 52

Drug Target Review

MAY 4, 2023

The researchers then use CRISPR to target each of the regions of the genomes implicated by GWAS and conduct single-cell sequencing to evaluate gene and protein expression. In their study, the researchers illustrated the use of STING-seq to discover target genes of noncoding variants for blood traits.

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Disease Small Molecule Protein Expression Research 52

The Pharma Data

SEPTEMBER 8, 2020

We remain committed to advancing the science in MS by investigating potential new medicines such as fenebrutinib, with the ultimate goal of halting progression of this disease,” said Levi Garraway, M.D., About Roche Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives.

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Clinical Trials Trials Disease FDA Approval 52

Codon

APRIL 9, 2023

“Computer science is to biology what calculus is to physics.” AI + Bio *Transfer learning for cross-context prediction of protein expression from 5’UTR sequence. Read Basic Science *mRNA decoding in human is kinetically and structurally distinct from bacteria. Science Translational Medicine.

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Drug Target Review

SEPTEMBER 10, 2024

For example, advances in media and feeds have contributed to higher cell protein expression by optimising nutrient availability and reducing accumulation of waste products within a culture. Novel vector design and synthetic promoters have been designed to maximise productivity and enhance gene expression stability.

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The Pharma Data

JANUARY 13, 2021

The project aims to develop novel protein expression systems by leveraging recent advances in direct cell reprogramming to help improve the production of proteins which are not produced sufficiently well in existing expression systems. Mogrify – U.K.-based

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Licensing Licensing Clinical Trials Trials 52

The Pharma Data

MARCH 26, 2021

PD-L1 is a protein expressed on tumour cells and tumour-infiltrating cells, which suppresses the immune response and enables tumour cells to avoid detection by binding to proteins on the surface of immune cells. Median OS in the Tecentriq arm was the same as observed at the previous analysis (20.2

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The Pharma Data

JANUARY 13, 2021

Dr. Lederman added, “We believe the development risk of TNX-1500 is mitigated by previous clinical data and extensive preclinical science with ruplizumab. CD40-ligand is a protein expressed on the surface of activated T lymphocytes that mediates T cell helper function. 175:1091-1101 (1992) 2 Karpusas, M et al., Structure.

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Pharmaceuticals Small Molecule Vaccine Protein Expression 52

The Pharma Data

MAY 4, 2021

PD-L1 is a protein expressed on tumour cells and tumour-infiltrating cells, which suppresses the immune response and enables tumour cells to avoid detection by binding to proteins on the surface of immune cells. Median OS in the Tecentriq arm was the same as observed at the previous analysis (20.2

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Treatment Therapies Disease Pharmaceuticals 52

The Pharma Data

AUGUST 9, 2021

HER2 is a tyrosine kinase receptor growth-promoting protein expressed on the surface of many types of tumours, including breast, gastric, lung and colorectal cancers. 3 HER2 protein overexpression may occur as a result of HER2 gene amplification and is often associated with aggressive disease and a poor prognosis in breast cancer.

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Trials Treatment Clinical Trials Protein Expression 52

The Pharma Data

SEPTEMBER 22, 2020

About Zolgensma ® ( onasemnogene abeparvovec ) Zolgensma ® is designed to address the genetic root cause of SMA by providing a functional copy of the human SMN gene to halt disease progression through sustained SMN protein expression with a single, one-time IV infusion.

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Clinical Development Therapies Clinical Trials Treatment 52

The Pharma Data

SEPTEMBER 2, 2020

“While conditions of the nervous system are some of the most complex to understand and treat, we are committed to following the science to reduce relapses in NMOSD and slow and eventually stop disease progression in MS,” said Levi Garraway, M.D., Roche’s Chief Medical Officer and Head of Global Product Development.

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Clinical Trials Disease Treatment Therapies 52

The Pharma Data

APRIL 8, 2021

Roche is continuing to advance the science in MS and is exploring the investigational medicine fenebrutinib. Based on preclinical studies, OCREVUS binds to CD20 cell surface proteins expressed on certain B cells, but not on stem cells or plasma cells, suggesting that important functions of the immune system may be preserved.

Clinical Trials 52

Clinical Trials Trials Disease Therapies 52

The Anticancer Fund

SEPTEMBER 29, 2021

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer Published in Science Translational Medicine A drug screen identifies floxacin antibiotics as inhibitors of RSK4, a kinase which is associated with drug resistance and metastasis.

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Clinical Trials Drugs Trials Protein Expression 40

The Pharma Data

OCTOBER 28, 2020

Professor of Pediatrics, Neurological Sciences and Biochemistry, Rush University Medical Center, and investigator in the GTX-102 clinical study. “It In almost all cases of Angelman syndrome, the maternal UBE3A allele is either missing or mutated, resulting in limited to no protein expression. Berry-Kravis, M.D.,

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Protein Expression Therapies Treatment Disease 40

The Pharma Data

JANUARY 15, 2021

3 HER2 is a tyrosine kinase receptor growth-promoting protein expressed on the surface of many types of tumors including breast, gastric, lung and colorectal cancer. 2,5 In the U.S., it is estimated that 27,600 new cases of gastric cancer were diagnosed in 2020 and more than 11,000 people died from the disease.

Treatment 52

Treatment Trials Disease Therapies 52

The Pharma Data

OCTOBER 26, 2020

Increased infiltrates, expression of immune related genes and higher PD-L1 protein expression were observed across all patients suggesting a remodeling of the tumor microenvironment consistent with a switch toward a “hot tumor” phenotype. Conclusions. Christophe Le Tourneau, M.D.,

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Vaccine Trials Treatment Virus 40

Drug Target Review

JANUARY 20, 2025

Molecular factors Molecular markers, such as protein expression and signalling pathway activation, also guide therapy choices. For example, PD-L1 expression predicts the response to immune checkpoint inhibitors.

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