Drug Discovery World

JUNE 23, 2023

The Food and Drug Administration (FDA) has granted accelerated approval to Elevidys (delandistrogene moxeparvovec-rokl), an adeno-associated virus (AAV) based gene therapy for the treatment of DMD. The FDA’s accelerated approval is based on an increase in Elevidys micro-dystrophin protein expression in skeletal muscle.

FDA Approval 243

FDA Approval Therapies FDA Protein Expression 243

Chemical Biology and Drug Design

DECEMBER 20, 2023

As such, triptolide is expected to be a potential drug for colorectal cancer treatment. The protein expression levels of nuclear factor-erythroid 2-related factor 2 (Nrf2), matrix metalloproteinase (MMP)-2, and MMP-9 were detected by western blotting. Its mechanism of action may be related to the inhibition of Nrf2 signaling.

Protein Expression 100

Protein Expression Treatment Drugs Research 100

Chemical Biology and Drug Design

AUGUST 2, 2023

Group 1: the control group, Group 2: STZ-induced diabetes+insulin treatment group, Group 3: STZ-induced diabetes+linagliptin treatment group, Group 4: STZ-induced diabetes+linagliptin+insulin treatment group, Group 5: STZ-induced diabetes+TUDCA treatment group, Group 6: STZ-induced diabetes+TUDCA+insulin treatment group.

Protein Expression 100

Protein Expression Therapies Treatment Research 100

Chemical Biology and Drug Design

FEBRUARY 15, 2024

However, the DE disease pathogenesis remains unclear, thereby affecting its clinical treatment. RT-qPCR and western blotting were used to test the mRNA and protein expression levels of IL-17 and retinoid-related orphan receptor-γt (RORγt). PGE2 was highly expressed in the DE mouse model.

Disease 100

Disease Protein Expression Regulations Treatment 100

Chemical Biology and Drug Design

JUNE 8, 2023

Compared with the control group (0 mM SAS), the proliferation of TE-1 cells was significantly inhibited by different concentrations of SAS for different time lengths, and 4 mM SAS treatment for 48 h could obtain the maximum inhibition rate (53.9%).

Protein Expression 100

Protein Expression Treatment Research 100

Drug Discovery World

SEPTEMBER 8, 2022

Pleco claims that its novel Plecoid therapies have the potential to positively change the balance of protein expression within the cancer microenvironment, removing the burden of toxic metals within the cell, thereby improving the effectiveness of existing chemotherapy. cases per 100,000 population).

Protein Expression 130

Protein Expression Drugs Government FDA 130

Chemical Biology and Drug Design

SEPTEMBER 25, 2023

Vinp treatment promotes Wnt proteins to connect the receptors complex on the cell membrane (consisting of FZD and LRP5/6), and then β-catenin is subsequently dissociated from the complex and translocated to the nucleus, activating transcription of downstream target genes. The mechanism diagram of Vinp on PD.

Disease 100

Disease Protein Expression Treatment Research 100

Chemical Biology and Drug Design

SEPTEMBER 24, 2023

This finding provides new ideas for the development of drug targets for the treatment of ischemic stroke. This research is powered to probe whether the molecular mechanism of JAS for IS treatment is coupled with microglia polarization. The polarization of microglia affects IS process.

Regulations 100

Regulations Protein Expression Treatment Research 100

Chemical Biology and Drug Design

MARCH 4, 2024

Abstract Anlotinib is used for the treatment of advanced non-small cell lung cancer; however, the emergence of drug resistance limits its clinical application. The expression of miR-181a-3p was inhibited; however, SHQ1 expression was increased by β-sitosterol treatment of A549/anlotinib cells.

Protein Expression 100

Protein Expression Regulations Treatment Drugs 100

Chemical Biology and Drug Design

AUGUST 9, 2023

A label-free proteomics technology was employed to investigate alterations in protein expression in LoVo cells treated with plumbagin. The LC-MS/MS proteomics assay revealed 78 proteins that were differentially expressed upon treatment with plumbagin.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

Chemical Biology and Drug Design

DECEMBER 6, 2023

However, the pharmacodynamic mechanism and molecular target of SP-FC in the treatment of HS are still unclear. Therefore, this study is intended to explore the mechanism and target of SP-FC in the treatment of HS through network pharmacology combined with in vitro cell and molecular biology experiments.

Molecular Biology 100

Molecular Biology Protein Expression Treatment Regulations 100

Chemical Biology and Drug Design

AUGUST 23, 2023

The protein expressions were detected via western blot. The THS showed increased inflammation response proteins, mitochondria-dependent apoptosis proteins, and had a compensation effect on the Akt pathway. Ligustrazine at doses of 100 and 1000 μg/mL was administrated in Kupffer cells isolated from THS rats.

Protein Expression 100

Protein Expression Protein Production Production Treatment 100

Chemical Biology and Drug Design

AUGUST 21, 2023

Further, the study detected the effect of SA on cell apoptosis, lipid peroxidation, Fe 2+ level, and ferroptosis-related proteins expression. Finally, the effect of HMGB1 expression on SA in H/R stimulation was studied. Such effects of SA on H/R-induced cells were rescued by HMGB1 overexpression.

Protein Expression 100

Protein Expression Treatment Research 100

Chemical Biology and Drug Design

SEPTEMBER 21, 2023

Concretely, CPT-11 induced delayed diarrhea rat model and intestinal epithelial cell (IEC)-6 cell injury model with Baicalein treatment as needed. Colonic pathological changes were analyzed by hematoxylin–eosin staining, and inflammatory factor expressions in serum were determined by enzyme-linked immunosorbent assay.

Protein Expression 100

Protein Expression Treatment Research 100

Chemical Biology and Drug Design

DECEMBER 8, 2023

ELANE knockdown offset CAMP silencing-mediated inhibition of viability and promotion of inflammatory factors and pyroptosis-related protein expression in LPS/ATP/BoNT/A-treated rat DRG neurons. Conclusively, BoNT/A alleviates rat DRG neuron pyroptosis during PHN by upregulating CAMP to inhibit ELANE.

Protein Expression 100

Protein Expression Treatment Research 100

Drug Discovery World

SEPTEMBER 13, 2023

A Translational Psychiatry publication indicates that SARS-CoV-2 infection, even when unnoticed or asymptomatic, can have an influence on the activation of the Human Endogenous Retrovirus W (W-ENV) protein in psychotic patients, in a context of innate immune inflammation.

Protein Expression 130

Protein Expression Clinical Trials Hospitals Trials 130

ASPET

OCTOBER 20, 2023

Western blotting was utilized for protein expression and epigenetic studies utilized chromatin immunoprecipitation methods. Furthermore, KET restored acetylated histone occupancy at the Bdnf promoter IV and induced BDNF protein expression in DFP rats. mg/kg s.c., At 6-m following DFP exposure, KET (10 mg/kg, i.p.)

Protein Expression 40

Protein Expression Clinical Trials Therapies FDA 40

ASPET

AUGUST 31, 2023

Proteomic analysis with the use of the Q Exactive HF mass spectrometer, combined with biostatistic tests, performed on UVA-irradiated keratinocytes indicated enhanced and lowered expression of 186 and 160 proteins, respectively.

Protein Expression 40

Protein Expression Treatment 40

Drug Target Review

MAY 22, 2024

Secondly, circRNAs can be engineered for more efficient protein expression by carefully selecting and optimising the IRES element, a sequence motif derived from viruses and used to initiate cap-independent translation from circRNA. What improvements in protein expression and durability have been demonstrated by the circVec 2.1

Therapies 58

Therapies RNA Protein Expression DNA 58

Advarra

JANUARY 11, 2024

The applications of mRNA-based therapies in cancer research represent one of the next groundbreaking steps toward improved cancer treatments. Adoptive T Cell therapies, therapeutic antibodies, and immunomodulatory proteins represent just some of the potentially beneficial treatment strategies for successful mRNA cancer trials.

Vaccine 52

Vaccine Therapies Clinical Trials Small Molecule 52

Drug Target Review

OCTOBER 6, 2023

This interview explores how CoRegen’s innovative techniques are not only transforming cancer treatment but also hold promise for a wide range of medical applications, all while minimising the side effects often associated with traditional therapies.

Small Molecule 110

Small Molecule Engineering Protein Expression Regulations 110

Drug Target Review

JANUARY 26, 2024

Dr Freimuth stated: “These infectivity assays showed that the human ACE2 protein expressed on these mouse cells is fully functional.” They also investigated the placement of ACE2 proteins onto nanoparticles for possible applications in rapid virus detection or infection treatment.

Production 113

Production DNA Virus Protein Expression 113

The Pharma Data

JANUARY 15, 2021

for the treatment of adult patients with locally advanced or metastatic HER2 positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. .–(BUSINESS WIRE) January 15, 2021 — Daiichi Sankyo Company, Ltd. In the U.S., Sammons Cancer Center and the W.W. Caruth, Jr.

Treatment 52

Treatment Trials Disease Therapies 52

PPD

OCTOBER 12, 2023

These treatments use a vector to introduce the desired nucleic acid code to replace or modify protein expression or use cells to alter/restore a specific cell type. Cell and gene therapies (CGTs) are one of the fastest growing areas in human therapeutics.

Laboratories 52

Laboratories Protein Expression Clinical Trials Pharmacokinetics 52

Drug Discovery World

APRIL 17, 2024

CAMP4 is the only company modulating gene expression at the transcriptional level to increase mRNA production and thereby increase healthy protein production. DS: You say on your website that your approach is applicable to any disease where increasing protein expression is beneficial. Can you give some examples?

Science 147

Science RNA Disease Protein Expression 147

Drug Target Review

FEBRUARY 19, 2024

Knowing that the work I was doing could potentially provide a new or improved treatment options helped me to persevere. I did my PhD project on elucidating the role of the p53 protein that is relevant in many cancers. There are many failures and setbacks in drug discovery, and you need a lot of resilience to keep going.

Molecular Biology 109

Molecular Biology Science Protein Expression Production 109

The Pharma Data

JUNE 7, 2023

1,2 While first-line treatment with immune checkpoint inhibitors with or without chemotherapy has improved outcomes for patients with NSCLC without AGAs, like EGFR or ALK, most patients eventually experience disease progression. 3,4,5 TROP2 is a protein expressed in more than 90% of NSCLC tumors. Source link: [link]

Trials 40

Trials Protein Expression Therapies Treatment 40

Conversations in Drug Development Trends

MAY 30, 2024

Since marketing authorization for the first breakthrough treatment in 1994, the steady increase in clinical trials reflects the community’s commitment to finding effective ALS treatments despite the numerous hurdles associated with clinical trial design, from proof-of-concept to pivotal trials. The MAA file in the E.U.

Treatment 81

Treatment Small Molecule Clinical Trials Therapies 81

Broad Institute

AUGUST 24, 2022

Louis have identified biological markers in triple negative breast cancer (TNBC) that are associated with resistance to chemotherapy treatment. It is imperative that we develop approaches to predict response so that only effective treatments are given. 33, was associated with resistance to chemotherapy treatment.

DNA 52

DNA Protein Expression Treatment Protein Production 52

The Pharma Data

MAY 2, 2022

The target of DF7001 is 5T4, a protein expressed on cancer cells and stromal cells that support tumor growth associated with poor prognosis in several cancers, including non-small cell lung cancer (NSCLC), pancreatic cancer, breast cancer, and head and neck squamous cell carcinomas (HNSCC). View the full release here: [link].

Licensing 52

Licensing Licensing Research Protein Expression 52

The Pharma Data

APRIL 27, 2022

HER2 testing is routinely used to determine appropriate treatment options for patients with metastatic breast cancer. Targeting the lower range of expression in the HER2 spectrum may offer another approach to delay disease progression and extend survival in patients with metastatic breast cancer.

Therapies 52

Therapies Trials Protein Expression Treatment 52

Drug Target Review

SEPTEMBER 4, 2023

10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. International research and symposium help to understand and combat regional challenges.

Drugs 110

Drugs RNA DNA Disease 110

PerkinElmer

AUGUST 25, 2019

When PD-L1 interacts with Programmed Death protein 1 (PD-1) on cancer-fighting white blood cells called T cells, it decreases their effectiveness. With no natural enemies left to stop tumor cells, they proliferate and lead to tumors that can even adapt to various treatments to evade immunity.

Protein Expression 52

Protein Expression Immune Response Treatment Research 52

Drug Discovery World

FEBRUARY 28, 2023

With only 10% of these conditions indicated for an approved therapy, there is a sizable opportunity for scientists and companies to develop treatments for patients with no other options to turn to. The post Unlocking the potential of mRNA for the future treatment of rare diseases appeared first on Drug Discovery World (DDW).

Disease 130

Disease Treatment Vaccine DNA 130

ASPET

MARCH 6, 2024

Western blot analysis of rat liver lysates and microsomes confirmed higher rCYP3A1 protein expression in untreated SLCO2B1 +/+ compared to Slco2b1 -/ - rats. The contrary was observed, when microsomes isolated from treatment naive animals were assessed for the OSI-420 formation after erlotinib exposure.

Protein Expression 40

Protein Expression Pharmacogenetics Treatment Drugs 40

The Pharma Data

SEPTEMBER 28, 2021

additionally , all five babies maintained the power to swallow and were ready to feed exclusively orally after 12 months of treatment. Food and Drug Administration (FDA) and European Medicines Agency (EMA) approved Evrysdi for the treatment of SMA in adults and youngsters 2 months aged and older.

Clinical Trials 52

Clinical Trials Protein Expression FDA Therapies 52

The Pharma Data

AUGUST 16, 2021

The vaccine candidate, presently at a preclinical development stage, is a non-chemically modified mRNA, encoding the prefusion stabilized full-length spike protein of the SARS-CoV-2 virus, and formulated within Lipid Nanoparticles (LNPs). CureVac had its initial public offering on the New York Nasdaq in August 2020.

Immune Response 52

Immune Response Vaccine Virus RNA 52