Broad Institute

JANUARY 14, 2025

His lab had just developed base editing, a gene-editing approach that makes single-letter changes in DNA and can shut down protein production using strategies including installing a stop signal in the genetic code. But the researchers needed to deliver the base editors to the brain.

Disease 144

Disease DNA Protein Production Treatment 144

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

Engineering 140

Engineering Protein Production RNA Vaccine 140

The Pharma Data

MARCH 23, 2022

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.

Virus 52

Virus Small Molecule Protein Production Research 52

Codon

MARCH 20, 2023

The molecular grammar of protein disorder guiding genome-binding locations. Nucleic Acids Research. Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. Krypotou E.

Virus 52

Virus Engineering RNA Small Molecule 52

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. A year before the initial outbreak, Wuhan researchers proposed nurturing a coronavirus with enhanced ability to attach onto, and enter, human cells. An altered virus could have escaped. Her points: 1. Coincidence?

Virus 52

Virus RNA DNA Science 52

Broad Institute

MAY 14, 2024

Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory. Then, during graduate school at the California Institute of Technology in the early 1960s, he was introduced to bacteriophage T7, a virus that infects Escherichia coli bacteria.

RNA 84

RNA Production Molecular Biology Laboratories 84

The Pharma Data

JANUARY 24, 2021

This new approach has been achieved through a close partnership with the University of Minnesota , USA and represents an excellent example of the new spirit of research collaboration that has accelerated the global fight-back against COVID-19.

Research 40

Research Virus Medical Schools Government 40