Drug Target Review

NOVEMBER 1, 2023

The mission of the CCDD is to discover novel small-molecule therapeutics for the treatment of cancer and progress them to hypothesis testing phase 1 clinical trials. We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Dark Matter Blog

JULY 16, 2021

My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. I was enticed by Arrakis’ founder Jen Petter to serve in one more operational role, leading the research group at Arrakis as the company launched as one of the first biotechs to target RNA with drug-like small molecules.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Codon

MARCH 20, 2023

. 🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Evolutionary-scale prediction of atomic-level protein structure with a language model. DeepBindGCN: Integrating molecular vector representation with graph convolutional neural networks for accurate protein-ligand interaction prediction.

Virus 52

Virus Engineering RNA Small Molecule 52

Codon

MAY 30, 2023

Read Programming inactive RNA-binding small molecules into bioactive degraders. Science Advances. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Science Advances. Science Advances. Molecular Therapy. Nature Communications.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Read Programming inactive RNA-binding small molecules into bioactive degraders. Science Advances. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Science Advances. Science Advances. Molecular Therapy. Nature Communications.

DNA 52

DNA RNA Engineering Vaccine 52

PLOS: DNA Science

AUGUST 8, 2024

Imprinting disorders can also result from differences between parental genders in gene expression – that is, protein production from the encoded information. We were able to show that (S)-PHA533533 had better uptake and that the same small molecule could be translated in human-derived neural cells, which is a huge finding.

Small Molecule 52

Small Molecule DNA Drugs Protein Production 52