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Target-directed cancer: protein-ligand interactions  

Drug Target Review

The mission of the CCDD is to discover novel small-molecule therapeutics for the treatment of cancer and progress them to hypothesis testing phase 1 clinical trials. We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production.

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The Active Ingredient Stands Alone

FDA Law Blog: Biosimilars

To set the stage for this case, we need to go back to March 2020 , when a new definition of “biological product” threw the world of protein products into a tizzy. And, like it has before , the District Court of D.C. recently grappled with this very question in Ipsen v.

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A Look Back

Dark Matter Blog

My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules. I was enticed by Arrakis’ founder Jen Petter to serve in one more operational role, leading the research group at Arrakis as the company launched as one of the first biotechs to target RNA with drug-like small molecules.

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Eloxx Pharmaceuticals to Report Third Quarter 2020 Financial Results and Provide Business Update on November 5, 2020

The Pharma Data

Premature stop codons are point mutations that disrupt protein synthesis from messenger RNA. As a consequence, patients with premature stop codon diseases have reduced or eliminated protein production from the mutation bearing allele accounting for some of the most severe phenotypes in these genetic diseases.

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Targeting a human protein may stop Ebola virus in its tracks

The Pharma Data

Without the stop sign, viral transcription no longer follows the correct order, which has a negative impact on viral protein production,” says Fang. “The virus hijacks this protein and makes it do something different than its normal job in cells. “We weren’t expecting to see this,” says Fang.

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Codon Digest: Bacteria Resist Every Virus

Codon

Point-of-care peptide hormone production enabled by cell-free protein synthesis. Marine biofilm engineered to produce current in response to small molecules. Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. DeWinter MA. ACS Synthetic Biology. ACS Synthetic Biology.

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Codon Digest: Discovering Antibiotics with Deep Learning

Codon

Read Programming inactive RNA-binding small molecules into bioactive degraders. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Molecular Therapy. Read Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.

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