Drug Discovery World

NOVEMBER 27, 2023

Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production. He has a post-doctorate in virology, viral pathogenesis, viral vector development, and vaccines evaluation from Harvard Medical School and a PhD in Virology/Molecular Biology.

Production 147

Production Engineering Molecular Biology Drug Development 147

Drug Target Review

MARCH 15, 2024

With more than 20 years of experience in business management, strategy, marketing and product management, Anis also has a research background in biotech, pharmaceutical and premier academic organisations. Anis also serves on the scientific and editorial advisory board of Genetic Engineering News at Mary Ann Liebert, Inc. Biotechnol Prog.

Engineering 104

Engineering Molecular Biology Protein Expression Medical Schools 104

The Pharma Data

JANUARY 16, 2021

Etta Biotech”), to set up a high titer transient protein expression platform for high quality protein production using JS Bio’s transient transfection media. JS Bio becomes the exclusive cell culture supplier for Etta Biotech’s transient transfection high titer protein expression platform.

Protein Expression 52

Protein Expression Protein Production Production Drug Development 52

Drug Discovery World

APRIL 30, 2024

The biggest growth driver for mRNA therapeutics came from the Covid-19 pandemic, when mRNA-based vaccines proved effective in treating SARS-CoV-2, and pharmaceutical companies such as Pfizer/BioNTech and Moderna were successful in bringing these treatments to market. mRNA is a molecule made up of a single strand of ribonucleic acid (RNA).

Therapies 130

Therapies RNA Vaccine Small Molecule 130

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

Engineering 140

Engineering Protein Production RNA Vaccine 140

Broad Institute

MAY 14, 2024

His T7 expression technology can be used to make large quantities of nearly any RNA or protein and has been for decades, and continues to be, a mainstay of biomedical research and pharmaceutical production. In 2020, scientists used the T7 platform to produce enough mRNA for COVID-19 vaccines to vaccinate millions of people in the U.S.

RNA 84

RNA Production Molecular Biology Laboratories 84

Drug Discovery World

AUGUST 1, 2023

As per a definition provided by AstraZeneca: “Once inside, ASOs bind with high specificity to target mRNA or pre-mRNA, inducing its degradation – effectively silencing it – to prevent its translation into a detrimental protein product.

RNA 130

RNA Vaccine Drugs Disease 130

Drug Discovery World

NOVEMBER 13, 2023

Next-generation immunotherapies The fourth track of PEGS Europe 2023 on the third day is ‘Next-generation immunotherapies’, which will feature a range of sessions made up of presentations, talks and posters which address cell-based immunotherapies, vaccines, and checkpoints and agonists.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Codon

MARCH 24, 2024

MenAfriVac is a meningococcal vaccine that remains active, without refrigeration, for up to four days and has significantly boosted vaccine coverage in parts of sub-Saharan Africa. Mixing the extracts with a bit of water and genetic material then “reboots” the enzymes, which make conjugate vaccines at a cost of about $0.50

Engineering 87

Engineering Vaccine Production RNA 87

Drug Discovery World

NOVEMBER 8, 2023

The presentations include: Mark Cragg, PhD, Professor of Experimental Cancer Biology, Antibody and Vaccine Group, School of Cancer Sciences, University of Southampton, on: ‘Modulating antibody effector functions in the tumour microenvironment’.

Engineering 162

Engineering Protein Expression Therapies Science 162

Drug Discovery World

NOVEMBER 30, 2023

From a product perspective, RedShiftBio had the Aurora protein analyser with them in Lisbon this year. With a small sample, Aurora fully and rapidly characterises biomolecules of interest, detecting structural changes early and more accurately than traditional spectroscopic methods.

Protein Expression 147

Protein Expression Engineering DNA Therapies 147

The Pharma Data

JANUARY 13, 2021

The Phase II clinical trial will evaluate Ultimovacs’ proprietary universal cancer vaccine, UV1, in combination with AstraZeneca’s durvalumab and olaparib in patients with relapsed ovarian cancer. UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase. Mogrify – U.K.-based

Licensing 52

Licensing Licensing Clinical Trials Vaccine 52

Codon

MAY 30, 2023

Read *An engineered influenza virus to deliver antigens for lung cancer vaccination. Read Meningococcal ACWYX conjugate vaccine in 2-to-29-year-olds in Mali and Gambia. Read | News Improving the soluble expression of difficult-to-express proteins in prokaryotic expression system via protein engineering and synthetic biology strategies.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Read *An engineered influenza virus to deliver antigens for lung cancer vaccination. Read Meningococcal ACWYX conjugate vaccine in 2-to-29-year-olds in Mali and Gambia. Read | News Improving the soluble expression of difficult-to-express proteins in prokaryotic expression system via protein engineering and synthetic biology strategies.

DNA 52

DNA RNA Engineering Vaccine 52

The Pharma Data

JANUARY 24, 2021

As the world begins to see a route out of the pandemic it is worth remembering that a small but significant sub-set of patients will not respond to vaccines effectively because of their underlying health conditions. It is therefore vital that we continue with drug discovery approaches in parallel with the global vaccination role out.”

Research 52

Research Virus Medical Schools Government 52

Codon

MARCH 20, 2023

Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. How cell-free processes could speed up vaccine development. Metabolic Engineering. ACS Synthetic Biology.

Virus 52

Virus Engineering RNA Small Molecule 52

Codon

AUGUST 10, 2023

Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. & Ueda T. Nature Protocols (2015). Molecular Systems Biology (2008).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52