Drug Discovery World
FEBRUARY 19, 2024
At all assessed doses, RBI-4000 was well-tolerated and achieved a strong immune response, with protective virus-neutralising antibody titers above the World Health Organization (WHO)-defined immune surrogate level of protection against the rabies virus. Preliminary data show that the surrogate metric of protection (RVNA≥0.5)
The Pharma Data
MARCH 23, 2022
To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.
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Drug Discovery World
OCTOBER 24, 2022
A scientist at Oregon State University has demonstrated in a mouse model that it’s possible to prompt the production of a protein that can block multiple variants of the SARS-CoV-2 virus from entering cells and causing respiratory disease. . This prevents the virus from latching onto cells in the host’s airway. .
Drug Discovery World
FEBRUARY 13, 2023
Using AI, researchers at Chalmers University of Technology, Sweden succeeded in designing synthetic DNA that controls the cells’ protein production. Meanwhile, Poolbeg Pharma and OneThree Biotech have discovered novel drug targets for the treatment of respiratory syncytial virus (RSV) using an AI programme.
PLOS: DNA Science
JUNE 13, 2024
The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. An altered virus could have escaped. Evidence that the virus emerged, or escaped, from the wildlife trade is lacking. Her points: 1. Coincidence? I’ve never thought so. RaTG13 shares about 96.1%
Drug Discovery World
NOVEMBER 17, 2022
For example, when certain immune cells sense a virus, they release sub-compartments to their environment, which act as signal for other types of cells to destroy that virus. . A fundamental feature of biological cells across all forms of life is the compartmentalisation of cells, which can change in response to environmental stimuli.
Drug Target Review
APRIL 5, 2024
Together, these attributes provide a strong foundation for protein expression with enough adaptability to produce much of the commercial and therapeutic protein market. Skilled CDMOs can also locate or create favourable genomic microenvironments where transcription factors are efficiently recruited, further boosting protein production.
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