Science Daily: Pharmacology News

AUGUST 30, 2023

Disrupted connections between memory and appetite regulating brain circuits are directly proportional to body mass index (BMI), notably in patients who suffer from disordered or overeating that can lead to obesity, such as binge eating disorder (BED), according to new research.

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Science Daily: Pharmacology News

MARCH 26, 2025

Tropical marine low clouds play a crucial role in regulating Earth's climate. Now, researchers have developed a groundbreaking method that significantly improves accuracy in climate predictions. However, whether they mitigate or exacerbate global warming has long remained a mystery.

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Science Daily: Pharmacology News

DECEMBER 6, 2023

Although this had already been observed in the local universe, an international research team has just revealed the existence of the phenomenon in galaxies which are more than 7 billion years old and actively forming stars, the category to which most galaxies belong.

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Regulations International Research 217

Science Daily: Pharmacology News

MAY 10, 2024

Researchers describe the risks of deception by AI systems and call for governments to develop strong regulations to address this issue as soon as possible. Many artificial intelligence (AI) systems have already learned how to deceive humans, even systems that have been trained to be helpful and honest.

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Government Regulations Research 353

Science Daily: Pharmacology News

AUGUST 9, 2024

Catastrophic volcanic eruptions that warmed the planet millions of years ago shed new light on how plants evolve and regulate climate. Researchers reveal the long-term effects of disturbed natural ecosystems on climate in geological history and its implications for today.

Regulations 327

Regulations Research 327

Science Daily: Pharmacology News

AUGUST 20, 2024

The research could reshape scientists' understanding of gene regulation and how genetic variations may influence gene expression in development or disease. A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome.

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Science Daily: Pharmacology News

SEPTEMBER 12, 2024

Researchers have shown unprecedented control of SIV replication and decay of viral reservoirs by combining a stringent model of infection with the interruption of antiretroviral therapy (ART).

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Regulations Therapies Research 296

Science Daily: Pharmacology News

JULY 2, 2024

But new research shows that, for some, it may be just as important to consider the proteins and fats in their diet. When it comes to managing blood sugar levels, most people think about counting carbs.

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Production Regulations Research 327

Science Daily: Pharmacology News

JANUARY 21, 2025

The research team found that these neurons regulate key aspects of the brain-heart-gut axis. A new study has identified a group of neurons that, when activated, can induce a hypometabolic state, akin to hibernation.

Regulations 299

Regulations Disease Research 299

Science Daily: Pharmacology News

DECEMBER 12, 2024

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.

Immune Response 285

Immune Response Regulations Therapies Research 285

Science Daily: Pharmacology News

JANUARY 8, 2025

Nations must better safeguard health and reduce childhood diseases linked to exposures to toxic chemicals, according to researchers. Governments need to test and regulate chemicals and chemical products as closely as they safeguard prescription drugs, the researchers write.

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Production Government Regulations Disease 270

Science Daily: Pharmacology News

SEPTEMBER 26, 2024

Now, new research has unveiled a critical timing factor -- specifically how long cells actively respond to injury -- involved in regulating regeneration. Yet, some animals have an extraordinary capacity to regenerate after injury, a response that requires a precise sequence of cellular events.

Regulations 301

Regulations Research 301

Science Daily: Pharmacology News

OCTOBER 24, 2024

Researchers discovered potentially far-reaching effects of a particular gut bacterium that was linked to better growth in Bangladeshi children receiving a therapeutic food designed to nurture healthy gut microbes.

Immune Response 290

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Science Daily: Pharmacology News

JULY 27, 2023

A gene encoding a protein linked to tau production -- tripartite motif protein 11 (TRIM11) -- was found to suppress deterioration in small animal models of neurodegenerative diseases similar to Alzheimer's disease (AD), while improving cognitive and motor abilities, according to new research.

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Disease Regulations Treatment Production 189

Drug Target Review

SEPTEMBER 8, 2023

New researched published in the journal Immunity , T cells exhibit an unusual, yet vital behaviour in their battle against pathogens and cancer cells, involving a nuclear receptor. This receptor, referred to as retinoic acid receptor alpha (RARα), is recognised for its regulation of gene expression within the nucleus.

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Regulations Research DNA Immune Response 98

Drugs.com

NOVEMBER 11, 2024

11, 2024 -- Thousands of Americans with heart trouble have small implanted defibrillators, to help regulate their heartbeat and keep cardiac events at bay. But new research finds that on extremely hot days, people with the devices face. MONDAY, Nov.

Regulations 246

Regulations Research 246

Science Daily: Pharmacology News

JANUARY 24, 2024

Despite strict EU regulations on plastic recycling, there is little oversight on plastic waste shipped from the EU to Vietnam. A large percentage of the exported European plastic cannot be recycled and gets dumped in nature, according to recent research.

Regulations 260

Regulations Research 260

Science Daily: Pharmacology News

SEPTEMBER 2, 2024

New research suggests that alternative splicing may have an even greater influence on biology than just by creating new protein isoforms. The study shows that the biggest impact of alternative splicing may come via its role in regulating gene expression levels.

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Regulations Research 233

Science Daily: Pharmacology News

MARCH 25, 2025

Although many metabolic changes have been studied, body temperature regulation and environmental temperature preference during and after pregnancy remain poorly understood. Researchers show that postpartum female mice develop new environmental temperature preferences and reveal brain changes mediating these changes.

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Regulations Research 229

Drugs.com

JULY 28, 2023

Researchers found that metformin -- a drug that has been around for more than a half-century to regulate blood. FRIDAY, July 28, 2023 -- The diabetes drug metformin might also benefit older patients after an injury or illness, a small study suggests.

Regulations 245

Regulations Research Drugs 245

FDA Law Blog: Drug Discovery

NOVEMBER 10, 2024

Background on the Grants Program Launched as part of the Orphan Drug Act of 1983, this program aims to encourage research and development of drugs, biologics, medical devices, and medical foods for rare diseases, defined as conditions that affect fewer than 200,000 people in the U.S. The seven awardees included six early-stage trials (e.g.,

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Clinical Development Production Clinical Trials Treatment 69

Science Daily: Pharmacology News

OCTOBER 27, 2023

Researchers have discovered a protein that seals plant roots to regulate the uptake of nutrients and water from the soil, the discovery could help develop climate proof crops that require less water and chemical fertilizers.

Regulations 228

Regulations Research 228

Science Daily: Pharmacology News

AUGUST 30, 2023

Researchers have developed a miniature battery that could be used to power tiny devices integrated into human tissues. The device was able to regulate the biological activity of human neurons. The design uses an ionic gradient across a chain of droplets -- inspired by how electric eels generate electricity.

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Regulations Research 239

Drugs.com

AUGUST 8, 2024

8, 2024 -- That vape pen might contain something even worse than nicotine, new research warns.Tobacco companies may be trying to duck federal restrictions on vaping products by replacing nicotine with “nicotine analogs” -- related che. THURSDAY, Aug.

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Regulations Production Research 130

Science Daily: Pharmacology News

OCTOBER 24, 2023

Newly published research proves that it's possible to treat high blood pressure by using specially engineered Lactobacillus paracasei to produce a protein called ACE2 in the gut, reducing gut angiotensin II and, in turn, lowering blood pressure.

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Science Daily: Pharmacology News

NOVEMBER 15, 2023

This marks the first time researchers have used the technology to generate hair follicles, which play an important role in skin healing and function. However, hair follicles are quite important: They produce sweat, helping regulate body temperature, and they contain stem cells that help skin heal.

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Engineering Regulations Research Drugs 244

Science Daily: Pharmacology News

NOVEMBER 29, 2023

Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage.

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Regulations Disease Research 231

Science Daily: Pharmacology News

NOVEMBER 13, 2023

A compound -- one of 27 million screened in a library of potential new drugs -- reversed four types of chronic pain in animal studies, according to new research.

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Small Molecule Regulations Drugs Research 226

Broad Institute

OCTOBER 23, 2024

Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P.

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Research DNA Laboratories Molecular Biology 136

Drug Target Review

NOVEMBER 3, 2023

Organoid group (Hubrecht Institute) researchers, collaborating with researchers at the Princess Máxima Center and Maastricht University, used gut organoids to perform a systematic CRISPR screening of 1800 human transcription factors. Through the process of differentiation, stem cells develop into different cell types of the human gut.

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Research Regulations DNA Government 111

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- An amino acid found in meat, fish and energy drinks might be a key regulator of aging in animals, a new study suggests. Researchers. However, experts warn that no one should start seeing Red Bull as a fountain of youth.

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Regulations Research 214

Science Daily: Pharmacology News

MAY 1, 2024

Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation.

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Regulations Research 177

Science Daily: Pharmacology News

JANUARY 23, 2025

Researchers have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some men don't produce enough sperm and are infertile.

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Regulations Research 177

Advarra

MARCH 6, 2025

Institutional review boards (IRBs) play a crucial role in the ever-evolving field of clinical research. Without clinical research, these medical breakthroughs would remain out of reach for patients. Advarra draws members from leading academic institutions, government agencies, and clinical research organizations.

Clinical Research 52

Clinical Research Research Clinical Trials Bioethics 52

Chemical Biology and Drug Design

NOVEMBER 1, 2023

Kaempferol exerted antioxidant effects in AR-DOR by inhibiting Hsp90 to up-regulate Nrf2. In this study, 36 volunteers and 78 DOR patients (37 patients with EXD treatment) were enrolled in the clinical research. In summary, kaempferol exerts an antioxidant effect on AR-DOR by inhibiting HSP90 expression to up-regulate NRF2 expression.

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Regulations Treatment Clinical Research Research 100

PPD

FEBRUARY 19, 2024

The European Union Clinical Trial Regulation (EU CTR) brings the biggest change in the regulatory landscape since the implementation of the EU Clinical Trials Directive in 2004, requiring vast changes in the way organizations are structured and conduct their day-to-day activities.

Clinical Trials 96

Clinical Trials Regulations Trials Clinical Research 96

Advarra

AUGUST 8, 2024

Artificial intelligence (AI) has taken the world by storm – and regulators are paying attention. The EU AI Act’s implications extend into clinical research, where AI is increasingly utilized for tasks like medical image analysis, natural language process for endpoint analysis, and generating/analyzing data for synthetic control arms.

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Clinical Research Research Clinical Trials Compliance 98