ASPET

JULY 19, 2023

Ras- G TPase-activating protein (SH 3 domain)- b inding p roteins (G3BP) are RNA binding proteins that plays a critical role in stress granule (SG) formation. SGs protect critical mRNAs from various environmental stress conditions by regulating mRNA stability and translation to maintain regulated gene expression.

RNA 100

RNA Virus Regulations Disease 100

Drug Target Review

JANUARY 2, 2024

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. In the lab, they labelled RNA molecules with fluorescent markers, enabling them to easily locate them within individual cells.

RNA 128

RNA Immune Response Therapies Disease 128

Chemical Biology and Drug Design

NOVEMBER 13, 2023

However, it is not clear whether propofol mediates OSCC progression through regulating circular RNA (circRNA) network. Quantitative real-time PCR was used to detect circ_0008898, miR-545-3p, and CT10 regulator of kinase-like protein (CRKL) expression. RNA interaction was confirmed by dual-luciferase reporter assay and RIP assay.

RNA 100

RNA Regulations Research 100

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. Further tests showed that the gene also regulates bacterial respiration under low oxygen conditions. They named the small RNA SicX (sRNA inducer of chronic infection X).

RNA 40

RNA Regulations Treatment Research 40

Drug Target Review

JULY 24, 2023

Researchers from Tokyo Tech’s World Research Hub Initiative conducted a study to investigate the regulation of gene expression in the apicoplast of the malaria parasite Plasmodium falciparum. Through phylogenetic analysis and microscopy techniques, they identified a nuclear-encoded apicoplast RNA polymerase σ subunit called ApSigma.

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Chemical Biology and Drug Design

JANUARY 23, 2024

A gradient of emodin and long noncoding RNA HCP5 overexpression plasmid/small interfering RNA targeting HCP5 (siHCP5) were used for treating CRC cells. Expression levels of RNAs and proteins were detected by utilizing quantitative real-time polymerase chain reaction and Western blot.

RNA 100

RNA Regulations Research 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

LINC00460 knockdown contributed to DDP sensitivity of cervical cancer by regulating TGFBI, providing a novel mechanism underlying the acquisition of DDP sensitivity. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

ASPET

AUGUST 10, 2023

Stc2 translates to a secreted disulfide-linked hormone, STC2 known to function in cell development, calcium and phosphate regulation, angiogenesis, and anti-apoptosis - albeit the comprehensive mechanism by which CA-AhR-STC2 axis confers anti-apoptosis is yet to be characterized.

RNA 100

RNA Regulations Treatment Disease 100

Chemical Biology and Drug Design

OCTOBER 27, 2023

Melatonin (MEL) has been investigated to be an essential regulator involved in bone metabolism, as well as BMSCs differentiation. Circular RNAs (circRNAs) are a unique kind of non-coding RNA and play an important regulatory role in OP.

RNA 100

RNA Regulations Treatment Research 100

Chemical Biology and Drug Design

AUGUST 7, 2023

RNA sequencing (RNA-seq) analysis identified 18 differentially expressed genes (DEGs) between D-galactose-treated and PPS-pretreated mice abdominal aorta.

RNA 100

RNA Regulations Research 100

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism. IGF2BP3 negatively regulated hsa_circRNA_103820 expression and interacted with it. Hsa_circRNA_103820 is implicated in the pathogenesis of multiple cancers, including lung cancer (LC).

Bioinformatics 100

Bioinformatics RNA Regulations Research 100

SCIENMAG: Medicine & Health

JUNE 11, 2023

Abu Dhabi, UAE (June 12): A team of researchers at NYU Abu Dhabi, led by Associate Professor of Biology Youssef Idaghdour and working in collaboration with clinicians at several Abu Dhabi hospitals, investigated the association between microRNAs, a class of small RNA molecules that regulate genes, and COVID-19 severity among 259 unvaccinated COVID-19 (..)

RNA 84

RNA Research Hospitals Regulations 84

ASPET

SEPTEMBER 6, 2023

Toll-like receptor (TLR) 7 and TLR8 are single-stranded RNA-sensing endosomal pattern recognition receptors that evolved to defend against viral infections. However, aberrant TLR7/8 activation by endogenous ligands has been implicated in the pathogenesis of autoimmune diseases including systemic lupus erythematosus.

Disease 100

Disease RNA Treatment Regulations 100

Chemical Biology and Drug Design

NOVEMBER 27, 2023

A6 play anticancer role by regulating Best1 and HIST1H2BJ. To clarify how A6 affected on MCF-7 cells, RNA-seq analysis was conducted to evaluate the whole genome effect of A6 on gene expression. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Chemical Biology and Drug Design

APRIL 1, 2023

Berberine has been shown in in vitro and in vivo studies to inhibit various types of cancer by activating the p-53 and cyclin-B expression, targeting various cell signalling pathways, to regulate the cell cycle. Berberine anticancer properties are demonstrated due to the interaction of berberine with micro-RNA.

Therapies 100

Therapies RNA Regulations Research 100

Broad Institute

DECEMBER 13, 2023

typeof="foaf:Image" /> New tool uses RNA sequencing to chart rich maps of cellular and tissue function When a scientist wants to study individual cells at the molecular level within an organ like the heart or brain, they usually break the tissue up to analyze the cells. However, some beads capture the RNA of multiple cells at once. “So

RNA 145

RNA Research DNA Hospitals 145

Chemical Biology and Drug Design

DECEMBER 28, 2023

RNA sequencing analysis was conducted to study the gene expression profiles of Formononetin-induced H1975_OR cells. However, the potentials and the mechanisms of Formononetin to counteract the Osimertinib resistance in NSCLC are unclear.

RNA 100

RNA Regulations Treatment Research 100

ASPET

OCTOBER 8, 2024

Additionally, RNA sequencing analysis pointed to the potential involvement of the TLR pathway in the anti-colitic effects induced by amitriptyline. To bolster our findings, in vitro studies demonstrated that amitriptyline down-regulated the TLR4/NF-B/MAPK signaling cascades in mouse macrophages stimulated with LPS.

RNA 100

RNA Regulations Treatment Research 100

Broad Institute

JUNE 29, 2023

The method, described today in Science , provides a way for scientists to learn new details on how translation is regulated within individual cell types and how that changes in disease. When we use RIBOmap to look at individual cells within tissues, we can start to discover how different cell types are regulating translation differently.”

Protein Production 105

Protein Production RNA Regulations Science 105

Chemical Biology and Drug Design

DECEMBER 1, 2023

circinteractome, and CircBank and validated using dual-luciferase reporter and RNA pull-down assays. Importantly, circ_0068464 could regulate ATG5 expression by functioning as a miR-520h molecular sponge. The molecular mechanisms related to circ_0068464 were predicted through online prediction websites Starbase 2.0,

RNA 100

RNA Regulations Treatment Drugs 100

Codon

AUGUST 26, 2024

Remdesivir and other broad-spectrum antivirals work by jamming up RNA-dependent RNA polymerase (RdRp), an enzyme that nearly all RNA viruses use to replicate their genomes. Other efforts to build broad-spectrum antivirals have focused on another conserved feature of viruses: double-stranded RNA.

RNA 94

RNA Virus DNA Vaccine 94

KIF1A

SEPTEMBER 16, 2023

Note: For simplicity I will use the term KIF1A when referring to UNC-104 Post-translational modifications: When we talk about modifications to proteins, it’s usually in the context of mutations – a modification to the KIF1A gene makes altered RNA, which translates into altered KIF1A protein.

Regulations 105

Regulations RNA Disease Research 105

Chemical Biology and Drug Design

FEBRUARY 26, 2024

The m 6 A-RNA immunoprecipitation (MeRIP) assay detected the m 6 A modification profile. METTL3 was highly expressed in DC samples and HG-induced HLECs, METTL3 deficiency protected HLECs against HG-mediated apoptotic and oxidative injury via down-regulating miR-4654.

RNA 100

RNA Regulations Therapies Research 100

Broad Institute

AUGUST 31, 2023

Through the imposition of a user-defined GRN in its architecture, GRouNdGAN simulates steady-state and transient-state single-cell datasets where genes are causally expressed under the control of their regulating transcription factors (TFs).

RNA 40

RNA Regulations 40

Broad Institute

JUNE 28, 2023

Today, scientists use these reactions to produce customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and many aspects of basic biomedical research. “I There, he became interested in how DNA was regulated and what its many sequences meant.

DNA 98

DNA RNA Science Therapies 98

Drug Target Review

AUGUST 9, 2023

14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts. Many potential toxic effects have been suggested, including the mis-splicing of the Stathmin-2 RNA transcript. 14 Image modified from Suk et al.

RNA 98

RNA Regulations Disease DNA 98

Broad Institute

MARCH 12, 2025

Gone FISH-ing Previously, researchers had combined single-cell RNA sequencing with CRISPR screening to examine gene networks within cells using tools such as Perturb-seq, but the cells spatial context wasnt captured.

RNA 90

RNA Science Research Disease 90

Drug Target Review

JULY 7, 2023

The epigenome (meaning ‘above the genome’) is a system of reversible marks regulating how the DNA is read, translated and used. 2 Additionally, the epigenetic editing toolkit allows for precise temporal regulation. RNA-guided transcriptional silencing in vivo with S. What is epigenetic editing? Molecular Therapy.

DNA 105

DNA Engineering Therapies Regulations 105

Drug Target Review

SEPTEMBER 25, 2024

BRAF and downstream mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors are combined to treat BRAF-mutated melanoma, for example. Inhibiting KDM5A, a regulator of cell proliferation, poses another interesting approach.

Small Molecule 105

Small Molecule Therapies Regulations Treatment 105

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. They found that certain genetic changes rewire the interactions between proteins.

DNA 98

DNA RNA Regulations Treatment 98

Broad Institute

JANUARY 22, 2024

Initially, there were two approaches: small hairpin RNA (shRNA)-based and now CRISPR-based experiments. But we discovered two negative regulators [inhibitors of gene expression], DUSP4 and DUSP6. As the cells were becoming resistant, their dependency on negative regulators became higher and higher.

Drugs 128

Drugs Therapies Regulations RNA 128

Drug Target Review

SEPTEMBER 4, 2023

I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. 2018): Silent Information Regulator 2 from Trypanosoma cruzi is a potential target to infection control, IntechOpen. We discovered it is highly effective and environmentally friendly. 12(11): e0006980.

Drugs 111

Drugs RNA DNA Disease 111

Broad Institute

FEBRUARY 27, 2024

Past Speakers Speaker Topic Jeffery Kelly Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases Chuan He RNA modification in gene expression regulation Richard Young Biomolecular condensates: new insights into regulation and dysregulation of cellular compartments David Liu Base Editing and Prime Editing: (..)

RNA 52

RNA DNA Regulations Disease 52

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

Research 52

Research RNA Molecular Biology Small Molecule 52

Broad Institute

MARCH 6, 2024

In the new study, McCarroll, Berretta, and colleagues used single-nucleus RNA sequencing, which measures gene expression in individual cells, to better understand how the brain naturally varies across individuals. They analyzed 1.2 million cells from 94 people with schizophrenia and 97 without.

Medical Schools 134

Medical Schools RNA Science Research 134

Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. Dr Dixon said: “Now that we know Foxp3 plays a greater role in regulatory T cell function, we may be able to find ways to turn up and down Foxp3 to regulate immunosuppression.”

Government 104

Government DNA RNA Regulations 104

Broad Institute

OCTOBER 23, 2024

By analyzing these predictions, the researchers discovered new patterns in the DNA, learning how the grammar of CRE sequences in the DNA impact how much RNA would be made – a proxy for how much a gene is activated. Tags: Genome regulation Machine Learning Pardis Sabeti Paper cited Gosai SJ, Castro RI, et al. Online October 23, 2024.

Research 136

Research DNA Laboratories Molecular Biology 136