Broad Institute

MARCH 14, 2024

Continuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues. Paper cited Mercer JAM, et al. March 14, 2024. Funding This work was supported in part by the National institutes of Health and the Howard Hughes Medical Institute.

Targeted Protein Degradation 141

Targeted Protein Degradation Small Molecule Medical Schools Science 141

Covalent Modifiers

NOVEMBER 2, 2023

Ashley R Julio, Flowreen Shikwana, Cindy Truong, Nikolas R Burton, Emil Dominguez, Alexandra Turmon, Jian Cao, Keriann Backus bioRxiv 2023.10.30.564067; doi: [link] Protein homeostasis is tightly regulated, with damaged or misfolded proteins quickly eliminated by the proteasome and autophagosome pathways.

Targeted Protein Degradation 189

Targeted Protein Degradation Small Molecule Regulations 189

BMG Labtech

JUNE 17, 2024

However, knowledge of how proteins are broken down and how degradation contributes to cellular regulation is more recent. The half-lives of proteins in cells are known to span from minutes to several days and differences in the rates of protein degradation contribute significantly to cell regulation.

Targeted Protein Degradation 40

Targeted Protein Degradation Regulations Research Science 40

Drug Hunter

AUGUST 21, 2023

The BBB is composed of specialized brain endothelial cells that regulate the distribution of molecules into and out of the brain from the blood. Unlike the endothelial BBB, the blood-cerebrospinal fluid-barrier (BCSFB) is made up of epithelial cells that similarly regulate the distribution of molecules between the blood and CSF.

Drugs 206

Drugs Disease Targeted Protein Degradation Screening Hits 206

Drug Target Review

JULY 5, 2024

Interneuron migration is regulated by L-type calcium channels (LTCCs), encoded by the CACNA1C gene. Her research interest is in the neuroscience and oncology areas using both traditional and targeted protein degradation approaches.

Drugs 64

Drugs Targeted Protein Degradation Disease FDA Approval 64

The Pharma Data

JANUARY 31, 2021

Ion channels are a class of integral membrane proteins that regulate the flow of ions across the cell membrane as a means of conducting signals between cells and their environment. . TOKYO and CAMBRIDGE, England , Feb.

Structure Based Drug Design (SBDD) 52

Structure Based Drug Design (SBDD) Targeted Protein Degradation Drugs Disease 52

LifeSciVC

FEBRUARY 5, 2025

Substantial biological validation: As transcription factors play central roles in the up-/down-regulation of distinct signaling cascades, we have the ability to look to other pathway regulators, whether that be upstream or downstream, to understand the degree to which a given pathways modulation has on disease.

Small Molecule 67

Small Molecule Targeted Protein Degradation Regulations Disease 67