Research - Drug Discovery Digest

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

JANUARY 22, 2025

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.

Research

Research Science Disease Drugs

Researchers create gel that can self-heal like human skin

Science Daily: Pharmacology News

MARCH 7, 2025

Now, a team of researchers has developed a hydrogel with a unique structure that overcomes earlier limitations, opening the door to applications such as drug delivery, wound healing, soft robotics sensors and artificial skin.

Research

Research Drugs

Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

Researchers at the Broad Institute of MIT and Harvard, Massachusetts General Hospital, and Harvard University took a fresh approach by building a remarkably diverse collection of molecular compounds that can be mined for those that target disease-related genetic variants in new ways.

Disease

Disease Research DNA Small Molecule

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Bridging Innovation & Patient Care: The Growing Role of AI

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How artificial intelligence could automate genomics research

Science Daily: Pharmacology News

DECEMBER 2, 2024

New research suggests that large language models like GPT-4 could streamline the process of gene set enrichment, an approach what genes do and how they interact. Results bring science one step closer to automating one of the most widely used methods in genomics research.

Research

Research Science

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

But its impact goes far beyond research. From Research to Real-World Care 🌎 Understand how AI-driven advancements are shaping personalized treatments and patient outcomes. AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis.

Clinical Trials

Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

DNA

DNA Research

Researchers identify previously unknown compound in drinking water

Science Daily: Pharmacology News

NOVEMBER 21, 2024

Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.

Research

Research Disease

Researchers solve a fluid mechanics mystery

Science Daily: Pharmacology News

FEBRUARY 3, 2025

Seven years ago, researchers caught an unexpected phenomenon on film: A pool of red dye that somehow 'knew' how to solve a maze filled with milk. Propelled forward by a couple drops of soap, it unerringly found its way, avoiding dead ends and even making 90 degree turns in its path toward the exit.

Research

Researchers make comfortable materials that generate power when worn

Science Daily: Pharmacology News

JANUARY 15, 2025

Researchers have demonstrated new wearable technologies that both generate electricity from human movement and improve the comfort of the technology for the people wearing them. The work stems from an advanced understanding of materials that increase comfort in textiles and produce electricity when they rub against another surface.

Research

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management.

Clinical Trials

Researchers discover simple solution to break down forever chemicals

Science Daily: Pharmacology News

FEBRUARY 5, 2025

A researcher has discovered a new method to remove so-called 'forever chemicals' from our drinking water by heating the PFAS with granular activated carbon. The discovery represents a significant breakthrough in managing PFAS-containing solid wastes, biosolids and spent adsorbent media that are major concerns to farmers and communities.

Research

Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

Science Daily: Pharmacology News

MARCH 12, 2025

New research suggests black holes may transition into 'white holes', ejecting matter and potentially even time back into the universe, defying our current understanding of these cosmic giants.

Research

New research uncovers exotic electron crystal in graphene

Science Daily: Pharmacology News

JANUARY 22, 2025

Researchers have identified a new class of quantum states in a custom-engineered graphene structure. The study reports the discovery of topological electronic crystals in twisted bilayer -- trilayer graphene, a system created by introducing a precise rotational twist between stacked two-dimensional materials.

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Research Engineering

Why our biological clock ticks: Research reconciles major theories of aging

Science Daily: Pharmacology News

JANUARY 21, 2025

Researchers have revealed that these theories may not be so different after all. Two major theories of aging both involve DNA, but in very different ways.

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Research DNA

Researchers combine holograms and AI to create uncrackable optical encryption system

Science Daily: Pharmacology News

JANUARY 30, 2025

Researchers developed a new optical system that uses holograms to encode information, creating a level of encryption that traditional methods cannot penetrate.

Research

A fast-moving belly flop: Researchers unveil the unique skills of cricket frogs

Science Daily: Pharmacology News

JANUARY 10, 2025

The way cricket frogs move across the surface of water has long been thought to resemble walking on water, but researchers have now discovered a different reality.

Research

Researchers discover class of anti-malaria antibodies

Science Daily: Pharmacology News

JANUARY 3, 2025

Antibodies that bind to a previously untargeted portion of the malaria parasite could lead to new monoclonal antibody treatments and vaccines for malaria.

Research

Research Vaccine Treatment

New research reveals secrets about locust swarm movement

Science Daily: Pharmacology News

MARCH 24, 2025

New research is reshaping our understanding of one of nature's most stunning yet destructive phenomena -- massive locust swarms moving together.

Research

What's the best way to organize people to generate ideas? New research offers insight

Science Daily: Pharmacology News

FEBRUARY 4, 2025

New research offers insight into these questions -- and some of the results are not what you'd expect. Is it better to work in large groups? Smaller ones? With other people who are similar or different?

Research

Polymer research shows potential replacement for common superglues with a reusable and biodegradable alternative

Science Daily: Pharmacology News

JANUARY 16, 2025

Researchers have developed an adhesive polymer that is stronger than current commercially available options while also being biodegradable, tunable, and reusable. The findings show how the common, naturally occurring polymer P3HB can be chemically re-engineered for use as a strong yet sustainable bonding agent.

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Research Engineering

Memories are not only in the brain, new research finds

Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories.

Research

Adults can learn absolute pitch: new research challenges long-held musical belief

Science Daily: Pharmacology News

FEBRUARY 12, 2025

However, research challenges this, demonstrating that adults can acquire this skill through rigorous training.

Research

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

JANUARY 30, 2025

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

FDA Approval

FDA Approval Doctors Research FDA

Vertex, startup Orna to partner on gene editing research

BioPharma Drive: Drug Pricing

JANUARY 7, 2025

The three-year partnership is another example of Vertex’s interest in improving on Casgevy, its CRISPR medicine for sickle cell and beta thalassemia.

Research

Predator robots help researchers uncover how larval zebrafish rapidly learn

Science Daily: Pharmacology News

FEBRUARY 20, 2025

A novel system that chases larval zebrafish around an arena with predator robots is enabling scientists to understand how these days-old fish quickly learn in the real world.

Research

Researchers' breakthrough method reveals clouds amplify global warming far more than previously understood

Science Daily: Pharmacology News

MARCH 26, 2025

Now, researchers have developed a groundbreaking method that significantly improves accuracy in climate predictions. Tropical marine low clouds play a crucial role in regulating Earth's climate. However, whether they mitigate or exacerbate global warming has long remained a mystery.

Research

Research Regulations

Do parents really have a favorite child? Here's what new research says

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study found that younger siblings generally receive more favorable treatment from parents. Meanwhile, older siblings are often granted more autonomy, and parents are less controlling towards them as they grow up.

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Research Treatment

Zebrafish protein unlocks dormant genes for heart repair

Science Daily: Pharmacology News

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Therapies

Therapies Research

Heat from the sun affects seismic activity on Earth

Science Daily: Pharmacology News

MARCH 4, 2025

Researchers explore the likelihood that Earth's climate, as affected by solar heat, plays a role in seismic activity.

Research

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Science Daily: Pharmacology News

MARCH 4, 2025

The groundbreaking procedure was developed to help people with injuries like chemical burns that lead to irreversible limbal stem cell deficiency, and the researchers hope the new findings warrant additional trials.

Clinical Trials

Clinical Trials Trials Therapies Treatment

An effort based at Broad is fostering dialogue between autism researchers, advocates, and families

Broad Institute

MARCH 25, 2025

Related groups Healthy Engagement in Autism Research Dialogue (HEARD) In recent years, public discussions about autism, autism research, and individuals with autism have revealed a wide range of views, at times becoming contentious. Phan : Im one of the newer perspectives entering into this conversation.

Research

Research Science Therapies Production

Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

FEBRUARY 10, 2025

The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries. Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs.

Research

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

DNA

DNA Virus Treatment Research

Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

JANUARY 1, 2025

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

Research

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Science Daily: Pharmacology News

OCTOBER 28, 2024

By tweaking a few very specific genes in the neurons of aging fruit flies, the researchers prevented F-actin buildup, maintained cellular recycling and extended the healthy lifespan of fruit flies by approximately 30%. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.

DNA

DNA Research

Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Science Daily: Pharmacology News

MARCH 4, 2025

In order to address this challenge, researchers have developed Bis(diimino)palladium coordination nanosheets (PdDI), a novel two-dimensional electrocatalyst that effectively facilitates the hydrogen evolution reactions while minimizing the use of precious metals like platinum, paving the way for affordable hydrogen production.

Production

Production Research

Could Olumiant Be A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- An existing drug might be able to treat an autoimmune disorder that causes dry eye, dry mouth, fatigue and muscle or joint pain. Baricitinib (Olumiant), a drug currently used to treat rheumatoid arthritis, appears to.

Disease

Disease Research Drugs

Drug candidate eliminates breast cancer tumors in mice in a single dose

Science Daily: Pharmacology News

JANUARY 22, 2025

Now, researchers have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects. Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women.

Treatment

Treatment Therapies Drugs Research

Obesity: Researchers discover a cause of leptin resistance -- and how to reverse it

Science Daily: Pharmacology News

MARCH 4, 2025

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

Research

Brain-wide activity change visualized as geometric patterns

Science Daily: Pharmacology News

FEBRUARY 21, 2025

Researchers have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns. They visualized different shapes as the ever-changing neuronal activity in the temporal and frontal lobes of the brain during object recognition and recalling memories.

Research

Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study has revealed the alarming extent glaciers have shrunk over the past 40 years in a global warming hotspot -- and the biggest retreat has occurred in recent years.

Research

School bans alone not enough to tackle negative impacts of phone and social media use, researchers find

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Students attending schools that ban the use of phones throughout the school day aren't necessarily experiencing better mental health and wellbeing, as the first worldwide study of its kind has found that just banning smartphones is not enough to tackle their negative impacts.

Research

Revolutionizing touch: Researchers explore the future of wearable multi-sensory haptic technology

Science Daily: Pharmacology News

MARCH 25, 2025

From virtual reality to rehabilitation and communication, haptic technology has revolutionized the way humans interact with the digital world.

Research

First operating system for quantum networks

Science Daily: Pharmacology News

MARCH 12, 2025

Researchers have announced the creation of the first operating system designed for quantum networks: QNodeOS. The research marks a major step forward in transforming quantum networking from a theoretical concept to a practical technology that could revolutionize the future of the internet.

Research

Researchers make breakthrough in bioprinting functional human heart tissue

Researchers create gel that can self-heal like human skin

Webinars

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Researchers devise new way to target and correct disease-related proteins

Webinars

How artificial intelligence could automate genomics research

Bridging Innovation & Patient Care: The Growing Role of AI

Researchers flip genes on and off with AI-designed DNA switches

Researchers identify previously unknown compound in drinking water

Researchers solve a fluid mechanics mystery

Researchers make comfortable materials that generate power when worn

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Researchers discover simple solution to break down forever chemicals

Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

New research uncovers exotic electron crystal in graphene

Why our biological clock ticks: Research reconciles major theories of aging

Researchers combine holograms and AI to create uncrackable optical encryption system

A fast-moving belly flop: Researchers unveil the unique skills of cricket frogs

Researchers discover class of anti-malaria antibodies

New research reveals secrets about locust swarm movement

What's the best way to organize people to generate ideas? New research offers insight

Polymer research shows potential replacement for common superglues with a reusable and biodegradable alternative

Memories are not only in the brain, new research finds

Adults can learn absolute pitch: new research challenges long-held musical belief

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

Vertex, startup Orna to partner on gene editing research

Predator robots help researchers uncover how larval zebrafish rapidly learn

Researchers' breakthrough method reveals clouds amplify global warming far more than previously understood

Do parents really have a favorite child? Here's what new research says

Zebrafish protein unlocks dormant genes for heart repair

Heat from the sun affects seismic activity on Earth

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

An effort based at Broad is fostering dialogue between autism researchers, advocates, and families

Boosting evolution: How humans unintentionally altered the skulls of pigs

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Key players in brain aging: New research identifies age-related damage on a cellular level

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Could Olumiant Be A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Drug candidate eliminates breast cancer tumors in mice in a single dose

Obesity: Researchers discover a cause of leptin resistance -- and how to reverse it

Brain-wide activity change visualized as geometric patterns

Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

School bans alone not enough to tackle negative impacts of phone and social media use, researchers find

Revolutionizing touch: Researchers explore the future of wearable multi-sensory haptic technology

First operating system for quantum networks

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