Research - Drug Discovery Digest

Does Federally Funded Research Justify A Piece Of Pharma’s Profits?

Forbes: Drug Truths

MARCH 4, 2024

The thought that all drugs arise from government funded research is a fallacy.

Research

Research Government Drugs

Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Commentary]

ASPET

JULY 26, 2024

Meanwhile decades of research have advanced our knowledge of cannabis pharmacology and particularly of the endocannabinoid system with which the components of cannabis interact. Here we highlight the challenges of cannabis research and the gaps in our knowledge of cannabis pharmacology and of the endocannabinoid system that it targets.

Research

Research Production

How artificial intelligence could automate genomics research

Science Daily: Pharmacology News

DECEMBER 2, 2024

New research suggests that large language models like GPT-4 could streamline the process of gene set enrichment, an approach what genes do and how they interact. Results bring science one step closer to automating one of the most widely used methods in genomics research.

Research

Research Science

Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

DNA

DNA Research

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management.

Clinical Trials

Researchers identify source of a brain cancer’s deadly transformation

Broad Institute

NOVEMBER 21, 2024

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations.

Research

Research Medical Schools DNA Hospitals

Machine learning guides researchers to new synthetic genetic switches

Broad Institute

OCTOBER 23, 2024

Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P.

Research

Research DNA Laboratories Molecular Biology

Researchers map communities of single cells in metastatic breast cancers

Broad Institute

OCTOBER 30, 2024

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.

Research

Research RNA Medical Schools Treatment

Researchers identify previously unknown compound in drinking water

Science Daily: Pharmacology News

NOVEMBER 21, 2024

Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.

Research

Research Disease

Researchers discover new bacterium that causes gut immunodeficiency

Science Daily: Pharmacology News

SEPTEMBER 26, 2024

Researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases. The team identified the bacterium, Tomasiella immunophila (T.

Research

Research Disease

Researchers demonstrate self-assembling electronics

Science Daily: Pharmacology News

DECEMBER 2, 2024

Researchers have demonstrated a new technique for self-assembling electronic devices. The proof-of-concept work was used to create diodes and transistors, and paves the way for self-assembling more complex electronic devices without relying on existing computer chip manufacturing techniques.

Research

'Out-of-body' research could lead to new ways to promote social harmony

Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Out-of-body experiences, such as near-death experiences, can have a 'transformative' effect on people's ability to experience empathy and connect with others, new research explains.

Research

Researchers confront new US and global challenges in vaccinations of adults

Science Daily: Pharmacology News

OCTOBER 7, 2024

Researchers discuss the multifactorial barriers including increasing vaccine hesitancy and new clinical and public health challenges in vaccinations of U.S. Over the past decade, decreasing vaccination rates now threaten the huge beneficial impacts of vaccinations in the U.S. and globally.

Vaccine

Vaccine Research

Research in 4 continents links outdoor air pollution to differences in children's brains

Science Daily: Pharmacology News

OCTOBER 1, 2024

A research team systematically analyzed 40 empirical studies, the majority of which had found that outdoor air pollution is associated with differences in children's brains. These differences include volumes of white matter, which is associated with cognitive function, connections throughout the brain and even early markers for Alzheimer's.

Research

Researchers combine the power of AI and the connectome to predict brain cell activity

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

With maps of the connections between neurons and artificial intelligence methods, researchers can now do what they never thought possible: predict the activity of individual neurons without making a single measurement in a living brain.

Research

Life from a drop of rain: New research suggests rainwater helped form the first protocell walls

Science Daily: Pharmacology News

AUGUST 21, 2024

New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.

RNA

RNA Research

The monarch butterfly may not be endangered, but its migration is, researchers find

Science Daily: Pharmacology News

OCTOBER 16, 2024

With vigorous debate surrounding the health of the monarch butterfly, new research may have answered the biggest question plaguing butterfly researchers. Why are the wintering populations declining while breeding populations are stable?

Research

Airborne plastic chemical levels shock researchers

Science Daily: Pharmacology News

OCTOBER 1, 2024

A new study documents how Southern Californians are chronically being exposed to toxic airborne chemicals called plasticizers, including one that's been banned from children's items and beauty products.

Research

Research Production

New research explores volcanic caves, advancing the search for life on Mars

Science Daily: Pharmacology News

NOVEMBER 18, 2024

Through the intricate study of lava tubes -- caves formed following volcanic eruptions when lava cools down -- an international team of researchers has uncovered clues about Earth's ancient environments that could be significant in the search for life on Mars.

Research

Research International

Have we found all the major Maya cities? Not even close, new research suggests

Science Daily: Pharmacology News

OCTOBER 29, 2024

Researchers used laser-guided imaging to uncover vast unexplored Maya settlements in Campeche, Mexico, revealing more than 6,500 pre-Hispanic structures, including a previously unknown large city with stone pyramids.

Research

Researchers use the sounds of healthy coral reefs to encourage growth of a new species of coral larvae

Science Daily: Pharmacology News

OCTOBER 23, 2024

The researchers found that now a second species of coral larvae responded to the sounds of a healthy reef played through a speaker, indicating 'acoustic enrichment' encourages coral to settle has the potential to be a widely applicable method among coral species for reef restoration.

Research

Memories are not only in the brain, new research finds

Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories.

Research

Neuroscience breakthrough: Research team has mapped the entire brain of an adult fruit fly for the first time

Science Daily: Pharmacology News

OCTOBER 2, 2024

Previous researchers have mapped the brain of a C. Scientists have made an enormous step toward understanding the human brain by building a neuron-by-neuron and synapse-by-synapse roadmap -- scientifically speaking, a 'connectome' -- through the brain of an adult fruit fly (Drosophila melanogaster).

Research

Research Disease

Researchers test ChatGPT, other AI models against real-world students

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

An experiment tested six generative large language models against students in an online introductory biomedical and health informatics course. The models scored higher than as many as three quarters of the real-world students in the class.

Research

Researchers give adult zebra finches back their ability to learn new songs

Science Daily: Pharmacology News

SEPTEMBER 3, 2024

We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges.

Research

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Science Daily: Pharmacology News

OCTOBER 17, 2024

A new study opens the door to cutting-edge solutions that could contribute to the realization of a system capable of processing quantum information in a simple yet powerful way. The work presents a method for manipulating the photonic states of light in a never-before-seen way, offering greater control over the evolution of photon propagation.

Research

Countdown to an ice-free Arctic: New research warns of accelerated timelines

Science Daily: Pharmacology News

DECEMBER 3, 2024

Scientists demonstrate how a series of extreme weather events could lead to the Arctic's first ice-free day within just a few years.

Research

Researchers complete the largest compilation of cancer prevalence across vertebrates

Science Daily: Pharmacology News

OCTOBER 25, 2024

For all its pervasiveness and the efforts to study it, cancer is still somewhat of a mystery. Why do some animals get it at a higher rate than others?

Research

Brain research: Study shows what your favorite film genres reveal about your brain

Science Daily: Pharmacology News

AUGUST 27, 2024

Crime films, action films, comedies, or documentaries? A person's favorite film genre reveals a lot about how their brain works. Fans of action films and comedies reacted very strongly to negative emotional stimuli, while participants who favored documentaries or crime films and thrillers had a significantly weaker reaction.

Research

Researchers discover new third class of magnetism that could transform digital devices

Science Daily: Pharmacology News

DECEMBER 11, 2024

A new class of magnetism called altermagnetism has been imaged for the first time in a new study. The findings could lead to the development of new magnetic memory devices with the potential to increase operation speeds of up to a thousand times.

Research

Researchers deal a blow to theory that Venus once had liquid water on its surface

Science Daily: Pharmacology News

DECEMBER 2, 2024

A team of astronomers has found that Venus has never been habitable, despite decades of speculation that our closest planetary neighbor was once much more like Earth than it is today.

Research

Saving the bats: Researchers find bacteria, fungi on bat wings that could help fight deadly white-nose syndrome

Science Daily: Pharmacology News

OCTOBER 23, 2024

Bacteria and fungi from the wings of bats could play a significant role in saving them from white-nose syndrome (WNS), a fungal disease affecting the skin of wings and muzzle, which has nearly wiped out vulnerable bat populations across North America.

Research

Research Disease

Could Olumiant Be A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- An existing drug might be able to treat an autoimmune disorder that causes dry eye, dry mouth, fatigue and muscle or joint pain. Baricitinib (Olumiant), a drug currently used to treat rheumatoid arthritis, appears to.

Disease

Disease Research Drugs

Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder [Minireview]

ASPET

SEPTEMBER 16, 2024

Recent work demonstrating the psychoplastogenic effects of psychedelics has reinvigorated research to examine their therapeutic potential in psychiatric conditions. Psilocybin, one psychedelic found in the Psilocybe genus of mushrooms, has exhibited promising antidepressant and anxiolytic effects in preclinical and clinical studies.

Treatment

Treatment Research

Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

Science Daily: Pharmacology News

AUGUST 22, 2024

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. With practice, the hydrogel's accuracy improved by up to 10%, resulting in longer rallies.

Research

Hidden fat predicts Alzheimer's 20 years ahead of symptoms

Science Daily: Pharmacology News

DECEMBER 2, 2024

Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study.

Disease

Disease Research

Fungus-controlled robots tap into the unique power of nature

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

In creating a pair of new robots, researchers cultivated an unlikely component, one found on the forest floor: fungal mycelia.

Research

Rethinking the dodo

Science Daily: Pharmacology News

AUGUST 16, 2024

Researchers are setting out to challenge our misconceptions about the Dodo, one of the most well-known but poorly understood species of bird. Researchers have undertaken the most comprehensive review of the taxonomy of the Dodo and its closest relative, the Rodriguez Island Solitaire.

Research

Unnoticeable electric currents could reduce skin infections

Science Daily: Pharmacology News

OCTOBER 24, 2024

Using a few zaps of electricity to the skin, researchers can stop bacterial infections without using any drugs. For the first time, researchers designed a skin patch that uses imperceptible electric currents to control microbes.

Research

Research Drugs

High Throughput AI-Driven Drug Discovery Pipeline

Nvidia Developer: Drug Discovery

OCTOBER 30, 2024

The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional.

Drugs

Drugs Treatment Disease Research

Boost Alphafold2 Protein Structure Prediction with GPU-Accelerated MMseqs2

Nvidia Developer: Drug Discovery

NOVEMBER 13, 2024

The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a.

Science

Science Research Drugs

'Forever chemicals' influence the development and function of the brain

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

A research team has investigated the effects of PFAS on the brain. Using a combination of modern molecular biology methods and the zebrafish model, the researchers revealed the mechanism of action and identified the genes involved. They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer.

Molecular Biology

Molecular Biology Research

Brain-wide decision-making dynamics discovered

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

The research shows that decision-making is a global process across the brain that is coordinated by learning. The findings could aid artificial intelligence research by providing insights into how to design more distributed neural networks.

Research

Ancient hot water on Mars points to habitable past

Science Daily: Pharmacology News

NOVEMBER 22, 2024

New research has uncovered what may be the oldest direct evidence of ancient hot water activity on Mars, revealing the planet may have been habitable at some point in its past.

Research

Does Federally Funded Research Justify A Piece Of Pharma’s Profits?

Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Commentary]

Trending Sources

How artificial intelligence could automate genomics research

Researchers flip genes on and off with AI-designed DNA switches

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Researchers identify source of a brain cancer’s deadly transformation

Machine learning guides researchers to new synthetic genetic switches

Researchers map communities of single cells in metastatic breast cancers

Researchers identify previously unknown compound in drinking water

Researchers discover new bacterium that causes gut immunodeficiency

Researchers demonstrate self-assembling electronics

'Out-of-body' research could lead to new ways to promote social harmony

Researchers confront new US and global challenges in vaccinations of adults

Research in 4 continents links outdoor air pollution to differences in children's brains

Researchers combine the power of AI and the connectome to predict brain cell activity

Life from a drop of rain: New research suggests rainwater helped form the first protocell walls

The monarch butterfly may not be endangered, but its migration is, researchers find

Airborne plastic chemical levels shock researchers

New research explores volcanic caves, advancing the search for life on Mars

Have we found all the major Maya cities? Not even close, new research suggests

Researchers use the sounds of healthy coral reefs to encourage growth of a new species of coral larvae

Memories are not only in the brain, new research finds

Neuroscience breakthrough: Research team has mapped the entire brain of an adult fruit fly for the first time

Researchers test ChatGPT, other AI models against real-world students

Researchers give adult zebra finches back their ability to learn new songs

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Countdown to an ice-free Arctic: New research warns of accelerated timelines

Researchers complete the largest compilation of cancer prevalence across vertebrates

Brain research: Study shows what your favorite film genres reveal about your brain

Researchers discover new third class of magnetism that could transform digital devices

Researchers deal a blow to theory that Venus once had liquid water on its surface

Saving the bats: Researchers find bacteria, fungi on bat wings that could help fight deadly white-nose syndrome

Could Olumiant Be A New Way to Treat Sjögren’s Disease? Researchers Are Hopeful

Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder [Minireview]

Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

Hidden fat predicts Alzheimer's 20 years ahead of symptoms

Fungus-controlled robots tap into the unique power of nature

Rethinking the dodo

Unnoticeable electric currents could reduce skin infections

High Throughput AI-Driven Drug Discovery Pipeline

Boost Alphafold2 Protein Structure Prediction with GPU-Accelerated MMseqs2

'Forever chemicals' influence the development and function of the brain

Brain-wide decision-making dynamics discovered

Ancient hot water on Mars points to habitable past

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