Broad Institute

OCTOBER 30, 2024

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.

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Broad Institute

FEBRUARY 27, 2025

An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.

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RNA Therapies DNA Virus 66

BioPharma Drive: Drug Pricing

APRIL 22, 2024

billion, is the latest research collaboration involving small molecule drugs that modify RNA. The deal, which could be worth up to $1.8

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RNA Small Molecule Disease Research 167

Science Daily: Pharmacology News

OCTOBER 9, 2024

161,979 new RNA viruses have been discovered using a machine learning tool that researchers believe will vastly improve the mapping of life on Earth and could aid in the identification of many millions more viruses yet to be characterized.

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Virus RNA Research 326

Science Daily: Pharmacology News

JUNE 8, 2023

Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins.

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RNA DNA Research 361

Science Daily: Pharmacology News

AUGUST 30, 2024

Researchers have uncovered a surprising genetic mechanism that influences the vibrant and complex patterns on butterfly wings. The team discovered that an RNA molecule, rather than a protein as previously thought, plays a pivotal role in determining the distribution of black pigment on butterfly wings.

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Science Daily: Pharmacology News

JULY 27, 2023

In a step forward in the development of genetic medicines, researchers have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

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RNA Research Therapies Disease 183

Drugs.com

JANUARY 3, 2024

3, 2024 -- A regularly prescribed class of heart medications might be capable of treating one of the most common forms of muscular dystrophy, a new study in mice suggests.Myotonic dystrophy type 1 (DM1) is caused by abnormal RNA. WEDNESDAY, Jan.

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RNA Research Drugs 243

Covalent Modifiers

FEBRUARY 25, 2024

TD19 irreversibly modifies the residues C100 and C267, preventing ALKBH5 from binding to m6A-containing RNA. Moreover, TD19 displays good anticancer efficacy in acute myeloid leukemia and glioblastoma multiforme cell lines.

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RNA Cell Based Assays Regulations Research 157

Science Daily: Pharmacology News

MAY 29, 2024

New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix.

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RNA DNA Therapies Treatment 299

Science Daily: Pharmacology News

JANUARY 16, 2024

RNA is thought to have sparked the origin of life by self-copying. Researchers have now revealed the atomic structure of an 'RNA copy machine' through cryo-EM. This breakthrough sheds light on a primordial RNA world and fuels advancements in RNA nanotechnology and medicine.

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BioPharma Drive: Drug Pricing

JUNE 3, 2024

The alliance hands Lilly an RNA-based therapy in preclinical testing for ALS and frontotemporal dementia, and includes a research collaboration to develop other, similar medicines.

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RNA Therapies Drugs Research 218

Science Daily: Pharmacology News

DECEMBER 20, 2023

A research team has uncovered a previously undetected mechanism in mice -- starring the genetic molecule RNA -- that could explain how each sensory cell, or neuron, in mammalian noses becomes tailored to detect a specific odor chemical.

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RNA Research 242

Broad Institute

JUNE 28, 2023

They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. The new study demonstrates that RNA-guided DNA-cutting mechanisms are present across all kingdoms of life. said Zhang.

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RNA DNA Research Engineering 139

Science Daily: Pharmacology News

AUGUST 30, 2023

Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).

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Engineering RNA Research 210

Drug Target Review

JUNE 15, 2023

In this article Drug Target Review’s Izzy Wood spoke to Sam Hasson, Director of Target Biology at Rgenta Therapeutics, a biotech firm in Massachusetts, US, that aims to develop small molecule therapeutics to target RNA processing. The field is faced with a number of obstacles that require specifically assay technologies to surmount.

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RNA Small Molecule Disease Assay Development 96

Broad Institute

JANUARY 8, 2024

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. Researchers have used a variety of methods to deliver these molecular machines to cells, including lipid nanoparticles and viruses.

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Engineering Research Virus DNA 144

SCIENMAG: Medicine & Health

AUGUST 14, 2023

A technique that enables scientists to record gene mutations and patterns of gene activity in individual cells has been extended to cover RNA splicing as well, in a study led by researchers at Weill Cornell Medicine, the New York Genome Center and the Princess Margaret Cancer Centre in Toronto.

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RNA Disease Research 83

Broad Institute

MARCH 12, 2025

Their method, known as Perturb-FISH, combines imaging-based spatial transcriptomic measurements with large-scale detection of CRISPR guide RNAs. In addition, the research team tested the method in a more complex system, using a xenograft model developed in the Broad Cancer Program. Paper cited Binan L, et al.

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RNA Science Research Disease 99

Drug Discovery Today

MAY 10, 2021

A new approach to tackling viruses by targeting the ‘control centre’ in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defence against future pandemics, according to new research at the University of Birmingham.

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RNA Virus Drugs Research 100

Drug Discovery Today

MAY 13, 2021

INDIANAPOLIS and LONDON — Eli Lilly and Company (NYSE: LLY) and MiNA Therapeutics Limited, a pioneer in RNA activation therapeutics, today announced a global research collaboration to develop novel drug candidates using MiNA’s proprietary small activating RNA (saRNA) technology platform.

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RNA Research Drugs 100

Broad Institute

OCTOBER 23, 2024

Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P.

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Research DNA Laboratories Molecular Biology 136

Crown Bioscience

JULY 15, 2024

In the world of RNA analysis, researchers have an array of technologies at their disposal. Each method comes with its unique strengths, making the choice dependent on specific research needs and constraints.

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RNA Research 52

Drug Target Review

DECEMBER 6, 2024

In drug discovery and biological research, the scientists workflow often follows a structured and iterative approach to ensure accuracy, reproducibility and scientific integrity. At the heart of any research is the scientific question. This acts as a safeguard against false positives and misinterpretation of the data.

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RNA Drugs Research Science 52

Drug Target Review

JANUARY 2, 2024

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. In the lab, they labelled RNA molecules with fluorescent markers, enabling them to easily locate them within individual cells.

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RNA Immune Response Therapies Disease 128

PLOS: DNA Science

JUNE 8, 2023

But some species control genetic responses another way – via RNA editing. Because the edits are in RNA, and not DNA, they are fleeting. In 2015, the researchers discovered that about 60 percent of the mRNAs in the common squid Doryteuthis pealeii are edited. ’ ” Rosenthal posed.

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RNA DNA Science Laboratories 52

Elrig

MARCH 25, 2025

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

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RNA Bioinformatics Science Pharmacokinetics 59

SCIENMAG: Medicine & Health

JUNE 11, 2023

Abu Dhabi, UAE (June 12): A team of researchers at NYU Abu Dhabi, led by Associate Professor of Biology Youssef Idaghdour and working in collaboration with clinicians at several Abu Dhabi hospitals, investigated the association between microRNAs, a class of small RNA molecules that regulate genes, and COVID-19 severity among 259 unvaccinated COVID-19 (..)

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Research RNA Hospitals Regulations 84

Broad Institute

NOVEMBER 23, 2023

By Allessandra DiCorato November 23, 2023 Credit: Jessica Hernandez, Broad Communications Related news Researchers uncover new CRISPR-like system in animals that can edit the human genome Microbial sequence databases contain a wealth of information about enzymes and other molecules that could be adapted for biotechnology.

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RNA DNA Engineering Science 135

Broad Institute

JUNE 18, 2024

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. The researchers also adapted SHINE to distinguish between different flu strains.

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Virus RNA Laboratories Medical Schools 144

SCIENMAG: Medicine & Health

JULY 27, 2023

Philadelphia, July 28, 2023—In a step forward in the development of genetic medicines, researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased (..)

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RNA Research Hospitals Disease 69

Dark Matter Blog

AUGUST 31, 2020

However, since most small molecule drugs target proteins in the cell, the vast majority of target identification methods available to research scientists are aimed at identifying interactions between small molecules and proteins. First, given an RNA target, could we identify where on the RNA an rSM bound?

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RNA Small Molecule Bioinformatics Computational Chemistry 52

Broad Institute

AUGUST 31, 2023

By Leah Eisenstadt August 31, 2023 Credit: Susanna Hamilton, Broad Communications Researchers studied the effects of a schizophrenia gene mutation in different regions of the mouse brain. One of these is the GRIN2A gene, which encodes a subunit of a protein complex called the NMDA receptor.

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RNA Medical Schools Research Science 143

Broad Institute

OCTOBER 21, 2024

By Leah Eisenstadt October 21, 2024 Credit: Kevin Middleton, Broad Communications In the Bhattacharyya lab, researchers develop methods to quickly identify the most appropriate treatments for bacterial infections. The findings appear in the Journal of Clinical Microbiology.

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RNA Hospitals Laboratories Medical Schools 115

Fierce BioTech

JULY 1, 2024

Streamlining the Path from Discovery to Patient – Simpler RNA Manufacturing with Aldevron’s Codex® HiCap RNA Polymerase swheeler Mon, 07/01/2024 - 17:17 Wed, 08/07/2024 - 10:00 Resource Type Webinar Kyle Studey, M.S. Codex ® is a trademark of Codexis, Inc. Listing Image aldevron 250x190.png

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RNA Engineering Research 40

Broad Institute

APRIL 4, 2024

A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis By Rose Circeo April 4, 2024 Breadcrumb Home A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

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RNA Bioethics Disease Research 52

Reprocell

AUGUST 8, 2024

In the ever-evolving landscape of drug discovery, the ability to extract and analyze DNA and RNA from clinical biospecimens has become a cornerstone of innovative research. It is critical for downstream applications such as RT-PCR, RNA sequencing, and Next Generation Sequencing (NGS).

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Clinical Research Research RNA DNA 52