Broad Institute

AUGUST 31, 2023

Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome.

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DNA RNA Engineering Laboratories 145

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

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Engineering Protein Production RNA Vaccine 140

Broad Institute

MAY 16, 2024

By Allessandra DiCorato May 16, 2024 Credit: Deverman lab Brain vasculature (in blue) surrounded by RNA (in orange) transcribed from the gene delivered to the brain in humanized mice using an engineered AAV targeting the human transferrin receptor.

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Therapies FDA Approval Engineering Disease 137

The Pharma Data

MARCH 23, 2022

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.

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Virus Small Molecule Protein Production Research 52

Broad Institute

DECEMBER 13, 2023

By Leah Eisenstadt December 13, 2023 Two teams of Broad researchers produced detailed maps of the mouse nervous system. Related news Researchers map brain cell changes in Alzheimer’s disease Courtesy of the Chen and Macosko labs. Courtesy of the Chen and Macosko labs. Courtesy of the Chen and Macosko labs.

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DNA Virus Research Engineering 140

Chemical Biology and Drug Design

JULY 27, 2023

cells induced by poly (I:C) were treated with or without PA, and then RNA-sequencing, GO and KEGG analysis were carried out to obtain the five differentially expressed genes (IL-1β, HMOX1, PTGS2, Abca1, and P65), which were verified by QRT-PCR and western blot. RNA-sequencing was applied to analyze the differentially expressed genes (DEGs).

RNA 100

RNA Virus Disease Drugs 100

Broad Institute

JANUARY 30, 2024

More bottles on the medicine shelf would help, but Bhattacharyya, who’s now also a research scientist, realized that science might lead to better tools for diagnosing and treating such challenging cases. TWO WHITE COATS Roby Bhattacharyya's mother, Maryka, visiting his graduate research lab at UCSF.

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Hospitals Medical Schools Virus Science 137

Codon

MARCH 20, 2023

Basic Science A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Nucleic Acids Research. Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment. Assembly of metabolons in yeast using Cas6-mediated RNA scaffolding. Nucleic Acids Research.

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Virus Engineering RNA Small Molecule 52

Broad Institute

JUNE 27, 2024

There are currently no treatments, but researchers from the Whitehead Institute for Biomedical Research and Broad Institute of MIT and Harvard have developed an approach that could one day be used to turn off the gene encoding this protein throughout the brain to treat or even prevent prion disease.

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Disease Therapies Engineering Clinical Trials 142

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. The authors found that tracr-L redirects Cas9 in S. The authors suggest natural tracr-L regulates autoimmunity.

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Research RNA Molecular Biology Small Molecule 52

Drug Target Review

SEPTEMBER 4, 2023

Infectious agents’ resistance was described at the European Union Research Parliament “as a widespread, multifaceted phenomenon that affects both living things and the environment, as well as their capacity to survive in the presence of drugs intended to either kill or inactivate them.”

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Drugs RNA DNA Disease 111

The Pharma Data

AUGUST 16, 2021

Researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen and the Julius Maximilians University Würzburg have now elucidated the underlying molecular mechanism. The antiviral agent incorporates RNA-like building blocks into the RNA genome of the virus. ” Mutations in the genome stop the virus.

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RNA Virus Clinical Trials Drugs 52

Advarra

MARCH 31, 2023

This trend came to the forefront during the COVID-19 pandemic, as the three most popular vaccines developed in response to the coronavirus contained engineered genetic materials in the form of mRNA or a genetically engineered virus. Either way, occupational exposure to these gene delivery systems bears potential risks to the research staff.

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Engineering Clinical Research Research Virus 52

PLOS: DNA Science

JULY 27, 2023

I tracked the numbers of sequenced SARS-CoV-2 genomes posted at GISAID every few days during the pandemic, contributed by researchers everywhere. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages. Right now it’s just below 16 million variations of the tiny genome.

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Disease DNA Virus RNA 98

Codon

DECEMBER 12, 2024

Among the report’s authors are 16 members of national academies, two Nobel Laureates, and several researchers who have previously been frontrunners in the quest to create mirrored life. ” 1 Now, it seems, these researchers have changed their minds. It would also be undetectable by key parts of the human immune system.

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DNA RNA Vaccine Virus 81

Drug Target Review

FEBRUARY 7, 2024

How does the Artificial Intelligence (AI) system developed by the research team contribute to understanding the interactions between SARS-CoV-2 viral protein fragments and the immune system? Third, since SARS-CoV-2 replicates faster than common cold coronaviruses, there are larger numbers of virus particles to fragment.

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RNA Virus Immune Response Engineering 69

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. A year before the initial outbreak, Wuhan researchers proposed nurturing a coronavirus with enhanced ability to attach onto, and enter, human cells. An altered virus could have escaped. Her points: 1.

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Virus RNA DNA Science 52

The Pharma Data

JULY 6, 2021

But HIV’s ability to mutate isn’t unique among RNA viruses – most viruses develop mutations, or changes in their genetic code, over time. Changes in mutationally constrained epitopes are rare, as they can cause the virus to lose its ability to infect and replicate, essentially rendering it unable to propagate itself.

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Vaccine Virus Research Immune Response 52

The Pharma Data

JANUARY 10, 2021

The VIR Seek SARS-CoV-2 Solution is a comprehensive workflow for the detection of SARS-CoV-2 on environmental surfaces that includes swabbing of environmental surfaces, RNA extraction, analysis by Reverse Transcription PCR (RT-PCR) and evaluation by an advanced algorithm.

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RNA Virus Research 52

PerkinElmer

JULY 13, 2020

The complex relationship between a virus and its host is one of the hottest topics in science right now, and has been given considerable attention in recent weeks as a result of the race to understand the virus that causes COVID-19 and its potential vulnerabilities.

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RNA Virus Laboratories Science 52

The Pharma Data

JANUARY 21, 2021

President Joe Biden has promised to re-energize the nation’s response to COVID-19, but one of his top pandemic advisors says that effort could be hamstrung by both the virus and the failings of the previous administration. People also haven’t been provided clear messaging on the messenger RNA vaccines, Osterholm added.

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Vaccine Virus RNA Research 52

PLOS: DNA Science

OCTOBER 24, 2024

In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining what was happening. “Do Your Own Research” Fuels Science Illiteracy COVID reawakened the mantra DYOR: do your own research. .

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Science Research Vaccine Government 57

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

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Treatment Immune Response Virus Drugs 72

The Pharma Data

OCTOBER 21, 2020

The COVID-19 pandemic has highlighted the urgent need for a novel, oral antiviral to treat this highly infectious and often deadly virus,” said Jean-Pierre Sommadossi, Ph.D., BOSTON, Oct. 22, 2020 (GLOBE NEWSWIRE) — Atea Pharmaceuticals, Inc. , Chief Executive Officer and Founder of Atea Pharmaceuticals.

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RNA Pharmaceuticals Virus Small Molecule 52

The Pharma Data

NOVEMBER 1, 2021

Rice University researchers have introduced an online portal to help researchers screen COVID-19 drug candidates that might attack specific proteins of the SARS-CoV-2 virus. Understanding these structures allows researchers to find binding partners that could, ideally, deactivate the virus.

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Virus RNA Engineering Drugs 52

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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RNA Immune Response DNA Molecular Biology 59

PerkinElmer

JUNE 14, 2021

The speed at which researchers developed effective vaccines to prevent the spread of COVID-19 required unprecedented international cooperation on a scale never seen before. Meanwhile, researchers are continuing to investigate possible treatments for patients suffering with the disease.

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Virus RNA Vaccine Treatment 52

The Pharma Data

DECEMBER 3, 2020

The methods developed by Mammoth Biosciences uses Cas12a to “detect the viral RNA sequences of the envelope (E) and nucleocapsid protein (N) genes, followed by isothermal amplification of the target, causing a visual reading with a fluorophore.” Sherlock Biosciences uses Cas13 to cut reporter RNA sequences after activation by guide RNA.

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RNA Virus DNA Disease 52

Drug Target Review

SEPTEMBER 28, 2023

After that, I spent over a decade at a large instrument and genomics company working in, and then leading, research and development. Could you share an example of a specific project or research that you have worked on and the impact it has had in your field? These are synthetic, not the live virus, so do not pose a risk of infection.

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DNA Organic Chemistry Science Virus 116

The Pharma Data

MARCH 8, 2022

Researchers led by Prof. The virus carries the information to produce a series of proteins, capable of inhibiting antiviral recognition systems of the infected cell. Actually, these systems could identify viral genetic material (here: Ribonucleic acids/RNAs) and sound the alarm. Camouflage protects virus from immune system.

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Clinical Pharmacology Immune Response RNA Virus 52

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). The lab created a plan with eight research institutions across three continents. Models of life became the dominant research paradigm in nearly every life-sciences field.

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The Pharma Data

JANUARY 14, 2021

14, 2021 — Multifocal microvascular injury has been observed in the brain and olfactory bulbs in postmortem observation of patients who died from COVID-19 , according to a research letter published online Dec. The researchers observed abnormalities on magnetic resonance imaging of brains from 10 patients. THURSDAY, Jan.

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RNA Virus Research 52

The Pharma Data

JANUARY 11, 2021

Moderna is following up on the success of its messenger RNA-based COVID-19 vaccine with plans to develop inoculations for numerous other infectious diseases, the company said Monday. The company is unlikely to run short of research funding this year. 18, 2020 ). Of those two dozen programs, 13 are now in clinical trials.

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Vaccine Clinical Trials RNA Virus 52

Codon

AUGUST 27, 2024

Identifying a new or unexpected pathogen quickly, particularly when it occurs in conjunction with other, more common illnesses, is a key challenge for doctors, researchers, and public health professionals concerned with disease preparedness and biosecurity.

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DNA Laboratories Hospitals Virus 83

The Pharma Data

JANUARY 31, 2021

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. FDA approval for prevention of infection caused by all known subtypes of hepatitis B virus in adults age 18 years and older. About Clover Biopharmaceuticals.

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Clinical Trials Vaccine Trials Virus 52

Codon

JUNE 25, 2024

Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. Researchers use DNA cloning to make numerous copies of a gene, which can then be inserted into living cells to study how that gene functions or otherwise coax the cell to make proteins. However, E.

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DNA RNA Laboratories Engineering 70

The Pharma Data

DECEMBER 10, 2020

Unsupervised use of this technique by people without medical training can lead to transmission of pathogens, according to Paul Carlson, principal investigator in the Laboratory of Mucosal Pathogens and Cellular Immunology at FDA’s Office of Vaccines Research and Review. The method could have other research uses, he said.

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FDA Laboratories RNA Virus 52