Research and Science - Drug Discovery Digest

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

JANUARY 22, 2025

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.

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David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

APRIL 5, 2025

David Liu receives Breakthrough Prize in Life Sciences By Corie Lok April 5, 2025 Breadcrumb Home David Liu receives Breakthrough Prize in Life Sciences Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. In 2013, Broad founding director Eric S.

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Global trust in science remains strong

Science Daily: Pharmacology News

JANUARY 20, 2025

A team of 241 researchers conducted the largest post-pandemic study of trust in science, societal expectations and public views on research priorities. A global survey spanning 68 countries reveals that public trust in scientists is still high.

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How artificial intelligence could automate genomics research

Science Daily: Pharmacology News

DECEMBER 2, 2024

New research suggests that large language models like GPT-4 could streamline the process of gene set enrichment, an approach what genes do and how they interact. Results bring science one step closer to automating one of the most widely used methods in genomics research.

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Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

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Researchers identify previously unknown compound in drinking water

Science Daily: Pharmacology News

NOVEMBER 21, 2024

Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.

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Researchers create gel that can self-heal like human skin

Science Daily: Pharmacology News

MARCH 7, 2025

Now, a team of researchers has developed a hydrogel with a unique structure that overcomes earlier limitations, opening the door to applications such as drug delivery, wound healing, soft robotics sensors and artificial skin.

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Researchers make comfortable materials that generate power when worn

Science Daily: Pharmacology News

JANUARY 15, 2025

Researchers have demonstrated new wearable technologies that both generate electricity from human movement and improve the comfort of the technology for the people wearing them. The work stems from an advanced understanding of materials that increase comfort in textiles and produce electricity when they rub against another surface.

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Monkeys are world's best yodellers -- new research

Science Daily: Pharmacology News

APRIL 2, 2025

The research provides significant new insights into the diverse vocal sounds of non-human primates, and reveals for the first time how certain calls are produced. The researchers have discovered that special anatomical structures called vocal membranes allow monkeys to introduce 'voice breaks' to their calls.

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Researchers discover simple solution to break down forever chemicals

Science Daily: Pharmacology News

FEBRUARY 5, 2025

A researcher has discovered a new method to remove so-called 'forever chemicals' from our drinking water by heating the PFAS with granular activated carbon. The discovery represents a significant breakthrough in managing PFAS-containing solid wastes, biosolids and spent adsorbent media that are major concerns to farmers and communities.

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Researchers demonstrate the UK's first long-distance ultra-secure communication over a quantum network

Science Daily: Pharmacology News

APRIL 7, 2025

Researchers have successfully demonstrated the UK's first long-distance ultra-secure transfer of data over a quantum communications network, including the UK's first long-distance quantum-secured video call.

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Why our biological clock ticks: Research reconciles major theories of aging

Science Daily: Pharmacology News

JANUARY 21, 2025

Researchers have revealed that these theories may not be so different after all. Two major theories of aging both involve DNA, but in very different ways.

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Researchers combine holograms and AI to create uncrackable optical encryption system

Science Daily: Pharmacology News

JANUARY 30, 2025

Researchers developed a new optical system that uses holograms to encode information, creating a level of encryption that traditional methods cannot penetrate.

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A fast-moving belly flop: Researchers unveil the unique skills of cricket frogs

Science Daily: Pharmacology News

JANUARY 10, 2025

The way cricket frogs move across the surface of water has long been thought to resemble walking on water, but researchers have now discovered a different reality.

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Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

Science Daily: Pharmacology News

MARCH 12, 2025

New research suggests black holes may transition into 'white holes', ejecting matter and potentially even time back into the universe, defying our current understanding of these cosmic giants.

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New research uncovers exotic electron crystal in graphene

Science Daily: Pharmacology News

JANUARY 22, 2025

Researchers have identified a new class of quantum states in a custom-engineered graphene structure. The study reports the discovery of topological electronic crystals in twisted bilayer -- trilayer graphene, a system created by introducing a precise rotational twist between stacked two-dimensional materials.

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What's the best way to organize people to generate ideas? New research offers insight

Science Daily: Pharmacology News

FEBRUARY 4, 2025

New research offers insight into these questions -- and some of the results are not what you'd expect. Is it better to work in large groups? Smaller ones? With other people who are similar or different?

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Feng Zhang awarded the National Medal of Technology and Innovation

Broad Institute

JANUARY 6, 2025

Feng Zhang awarded the National Medal of Technology and Innovation By Corie Lok January 6, 2025 Breadcrumb Home Feng Zhang awarded the National Medal of Technology and Innovation Zhang and 22 other individuals received the USs highest honors for science and technology. By Broad Communications January 6, 2025 Credit: Ryan K.

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Memories are not only in the brain, new research finds

Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories.

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Polymer research shows potential replacement for common superglues with a reusable and biodegradable alternative

Science Daily: Pharmacology News

JANUARY 16, 2025

Researchers have developed an adhesive polymer that is stronger than current commercially available options while also being biodegradable, tunable, and reusable. The findings show how the common, naturally occurring polymer P3HB can be chemically re-engineered for use as a strong yet sustainable bonding agent.

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Researchers give adult zebra finches back their ability to learn new songs

Science Daily: Pharmacology News

SEPTEMBER 3, 2024

We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges.

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Zebrafish protein unlocks dormant genes for heart repair

Science Daily: Pharmacology News

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

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Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Science Daily: Pharmacology News

OCTOBER 17, 2024

A new study opens the door to cutting-edge solutions that could contribute to the realization of a system capable of processing quantum information in a simple yet powerful way. The work presents a method for manipulating the photonic states of light in a never-before-seen way, offering greater control over the evolution of photon propagation.

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Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

FEBRUARY 10, 2025

The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries. Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs.

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Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

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Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Science Daily: Pharmacology News

OCTOBER 28, 2024

By tweaking a few very specific genes in the neurons of aging fruit flies, the researchers prevented F-actin buildup, maintained cellular recycling and extended the healthy lifespan of fruit flies by approximately 30%. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.

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Follow the water: Searching for a lunar oasis

Science Daily: Pharmacology News

JANUARY 28, 2025

Researchers may help bring science fiction to reality by providing a divining rod to guide future space missions. As humankind imagines living off-planet -- on the moon, Mars and beyond -- the question of how to sustain life revolves around the physical necessities of oxygen, food and water.

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Predator robots help researchers uncover how larval zebrafish rapidly learn

Science Daily: Pharmacology News

FEBRUARY 20, 2025

A novel system that chases larval zebrafish around an arena with predator robots is enabling scientists to understand how these days-old fish quickly learn in the real world.

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Brain-wide activity change visualized as geometric patterns

Science Daily: Pharmacology News

FEBRUARY 21, 2025

Researchers have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns. They visualized different shapes as the ever-changing neuronal activity in the temporal and frontal lobes of the brain during object recognition and recalling memories.

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Earliest days of Earth's formation

Science Daily: Pharmacology News

MARCH 26, 2025

New research sheds light on the earliest days of the earth's formation and potentially calls into question some earlier assumptions in planetary science about the early years of rocky planets.

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Researchers discover new third class of magnetism that could transform digital devices

Science Daily: Pharmacology News

DECEMBER 11, 2024

A new class of magnetism called altermagnetism has been imaged for the first time in a new study. The findings could lead to the development of new magnetic memory devices with the potential to increase operation speeds of up to a thousand times.

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Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Science Daily: Pharmacology News

MARCH 4, 2025

The groundbreaking procedure was developed to help people with injuries like chemical burns that lead to irreversible limbal stem cell deficiency, and the researchers hope the new findings warrant additional trials.

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Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

JANUARY 1, 2025

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

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Do parents really have a favorite child? Here's what new research says

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study found that younger siblings generally receive more favorable treatment from parents. Meanwhile, older siblings are often granted more autonomy, and parents are less controlling towards them as they grow up.

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Heat from the sun affects seismic activity on Earth

Science Daily: Pharmacology News

MARCH 4, 2025

Researchers explore the likelihood that Earth's climate, as affected by solar heat, plays a role in seismic activity.

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Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

Science Daily: Pharmacology News

JANUARY 16, 2025

A new study has revealed the alarming extent glaciers have shrunk over the past 40 years in a global warming hotspot -- and the biggest retreat has occurred in recent years.

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How AI will reshape pharma by 2025

Drug Target Review

DECEMBER 20, 2024

Smith identifies three key obstacles preventing broader acceptance of AI: Communication gaps : Pharmaceutical and computational science communities often struggle to understand each others technical languages, making collaboration difficult. He was a postdoctoral researcher in mathematics at the University of Waterloo.

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Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Science Daily: Pharmacology News

MARCH 4, 2025

In order to address this challenge, researchers have developed Bis(diimino)palladium coordination nanosheets (PdDI), a novel two-dimensional electrocatalyst that effectively facilitates the hydrogen evolution reactions while minimizing the use of precious metals like platinum, paving the way for affordable hydrogen production.

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School bans alone not enough to tackle negative impacts of phone and social media use, researchers find

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Students attending schools that ban the use of phones throughout the school day aren't necessarily experiencing better mental health and wellbeing, as the first worldwide study of its kind has found that just banning smartphones is not enough to tackle their negative impacts.

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What if we find nothing in our search for life beyond Earth?

Science Daily: Pharmacology News

APRIL 7, 2025

Using advanced statistical modeling, the research team sought to explore how many exoplanets scientists should observe and understand before declaring that life beyond Earth is either common or rare. What if we spend decades building advanced telescopes to search for life on other planets and come up emptyhanded?

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Obesity: Researchers discover a cause of leptin resistance -- and how to reverse it

Science Daily: Pharmacology News

MARCH 4, 2025

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

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New technology puts a spatial lens on CRISPR screening

Broad Institute

MARCH 12, 2025

Related group Spatial Technology Platform Related news Q&A: How a Broad team uses cutting-edge spatial technologies to enable new science Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular genes and measure the impact on the expression of other genes.

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Our DNA is at risk of hacking, warn scientists

Science Daily: Pharmacology News

APRIL 16, 2025

According to new research next-generation DNA sequencing (NGS) -- the same technology which is powering the development of tailor-made medicines, cancer diagnostics, infectious disease tracking, and gene research -- could become a prime target for hackers.

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Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

Science Daily: Pharmacology News

AUGUST 22, 2024

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. With practice, the hydrogel's accuracy improved by up to 10%, resulting in longer rallies.

Research

Researchers make breakthrough in bioprinting functional human heart tissue

David Liu receives Breakthrough Prize in Life Sciences

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Global trust in science remains strong

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How artificial intelligence could automate genomics research

Researchers flip genes on and off with AI-designed DNA switches

Researchers identify previously unknown compound in drinking water

Researchers create gel that can self-heal like human skin

Researchers make comfortable materials that generate power when worn

Monkeys are world's best yodellers -- new research

Researchers discover simple solution to break down forever chemicals

Researchers demonstrate the UK's first long-distance ultra-secure communication over a quantum network

Why our biological clock ticks: Research reconciles major theories of aging

Researchers combine holograms and AI to create uncrackable optical encryption system

A fast-moving belly flop: Researchers unveil the unique skills of cricket frogs

Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

New research uncovers exotic electron crystal in graphene

What's the best way to organize people to generate ideas? New research offers insight

Feng Zhang awarded the National Medal of Technology and Innovation

Memories are not only in the brain, new research finds

Polymer research shows potential replacement for common superglues with a reusable and biodegradable alternative

Researchers give adult zebra finches back their ability to learn new songs

Zebrafish protein unlocks dormant genes for heart repair

Quantum research breakthrough uses synthetic dimensions to efficiently process quantum information

Boosting evolution: How humans unintentionally altered the skulls of pigs

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Follow the water: Searching for a lunar oasis

Predator robots help researchers uncover how larval zebrafish rapidly learn

Brain-wide activity change visualized as geometric patterns

Earliest days of Earth's formation

Researchers discover new third class of magnetism that could transform digital devices

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Key players in brain aging: New research identifies age-related damage on a cellular level

Do parents really have a favorite child? Here's what new research says

Heat from the sun affects seismic activity on Earth

Pioneering research exposes huge loss of glaciers in one of the fastest-warming places on Earth

How AI will reshape pharma by 2025

Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

School bans alone not enough to tackle negative impacts of phone and social media use, researchers find

What if we find nothing in our search for life beyond Earth?

Obesity: Researchers discover a cause of leptin resistance -- and how to reverse it

New technology puts a spatial lens on CRISPR screening

Our DNA is at risk of hacking, warn scientists

Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

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