Drugs.com

FEBRUARY 18, 2025

18, 2025 -- A mobile "Man Van" screening program detected dozens of prostate cancer cases in disadvantaged neighborhoods of London, researchers report. TUESDAY, Feb. A team led by Dr. Masood Moghul of Royal Marsden Hospital in London reported its.

Screening Hits 130

Screening Hits Hospitals Research 130

Drug Target Review

APRIL 7, 2025

Advancements in screening technologies for small-molecule drug discovery including cellular assays, computational screening, and biophysics-based methods enhanced by structural biology breakthroughs have improved screening hit rates and facilitated the identification of drug candidates for previously undruggable targets.

Fragment Screening 52

Fragment Screening Drugs Small Molecule Biophysical Assays 52

Drug Target Review

NOVEMBER 1, 2023

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. I work in the Centre for Cancer Drug Discovery (CCDD) at The Institute of Cancer Research in London, which is an academic drug discovery centre. Acta Cryst. Acta Cryst. 2013) 56, 2059-2073.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

The ChEMBL-og

SEPTEMBER 1, 2021

In ChEMBL version 29, there are over 2 M bioactivity data points against fungal, bacterial or viral targets (for 460 K compounds) available for pathogen-related research. Since CO-ADD may re-screen hits against resistant bacterial strains or in cytotoxicity assays, more comprehensive data is available for some compounds.

Cell Based Assays 52

Cell Based Assays Screening Hits Small Molecule Virus 52

Practical Cheminformatics

AUGUST 3, 2023

It is quite a bit more potent than the values one finds with screening hits, which typically have IC50s in the single to double-digit µM range. Molecules with IC50 values less than 200nM are considered active, and molecules with IC50 values greater than or equal to 200nM are considered inactive.

Drugs 93

Drugs Biochemical Assays Metabolic Stability Screening Hits 93

Molecular Design

OCTOBER 14, 2018

The distinction between Type 1 and and Type 2 behaviors is an important and useful one to make from the perspective of drug discovery scientists who are making decisions as to which screening hits to take forward. The first was reported in 2014 by AstraZeneca( 16 ) and the second in 2016 by academic researchers and called Badapple.(

Screening Hits 52

Screening Hits FDA Approval Drugs FDA 52

Drug Hunter

AUGUST 21, 2023

The use of in silico and in vitro assays alleviates ethical concerns on extensive animal research in keeping with the three Rs (Replacement, Reduction, Refinement). Researchers replaced the acidic sulfonamide motif with a benzylic pyridine ether, which significantly improved the K p. Figure 14: Optimization of an NMT inhibitor by DNDi.

Drugs 206

Drugs Disease Targeted Protein Degradation Screening Hits 206