Drug Target Review

JULY 5, 2024

14 However, pharma, biotech companies and contract research organisations (CROs) are actively exploring the potential to scale up organoid screening capabilities ( Table 1 ). A regenerative approach to the treatment of multiple sclerosis. A significant challenge for the field is incorporating 3D models into high-throughput platforms.

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Targeted Protein Degradation Drugs Disease FDA Approval 65

The Pharma Data

SEPTEMBER 15, 2020

We are happy to support their scientific efforts as they tackle complex research challenges that potentially address critical unmet medical needs for patients. ” Trilo Therapeutics: Trilo Therapeutics is focused on the discovery of novel inhibitors of protein-protein interactions for therapeutic purposes.

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Targeted Protein Degradation Molecular Biology Small Molecule Science 52

Elrig

MARCH 22, 2023

Over the two days, we’ll bring together academia, industry, and the vendor community to discuss recent advancements in two ultra-exciting areas of drug discovery and biological research: therapeutic oligonucleotides and chemical biology. These fields are moving at remarkable speed and have huge potential to transform treatments.

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Targeted Protein Degradation Science Disease Laboratories 40

SugarCone Biotech

OCTOBER 6, 2024

Thus, it is not enough for 2 proteins to each be expressed on the same cell surface, other features such as protein mobility in the cell membrane must play a role. I suspect this is an area of active research. Indeed, if one just binds transferrin to Trf1 it will internalize, release iron and pop back up on the cell surface.

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Targeted Protein Degradation International Engineering Therapies 70

Drug Target Review

OCTOBER 4, 2023

Antibody-drug conjugates (ADCs) have been a groundbreaking approach to cancer treatment with their ability to deliver cytotoxic drugs directly to diseased cells while sparing healthy tissues. This targeted delivery allows enhanced therapeutic efficacy while reducing the harmful side effects commonly associated with traditional chemotherapy.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 127

Covalent Modifiers

JANUARY 7, 2025

Tomonori Tamura and Itaru Hamachi Accounts of Chemical Research 2025 58 (1), 87-100 DOI: 10.1021/acs.accounts.4c00628 4c00628 Selective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge in chemical biology.

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Targeted Protein Degradation Pharmaceuticals Research Treatment 147

LifeSciVC

FEBRUARY 5, 2025

However, in recent years, huge leaps have been made in drug discovery ranging from novel technologies unearthing new techniques for small molecule development to new modalities like targeted protein degradation that are beginning to open the door to a promising wave of transcription factor-directed therapeutic candidates.

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Small Molecule Targeted Protein Degradation Regulations Disease 67