Drug Discovery World

JUNE 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers three articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. and Choosing the right site solution for clinical trials.

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Clinical Trials Trials Drugs Pharmaceuticals 148

Drug Discovery World

JULY 12, 2024

Scientists at the University of Oxford in the UK have launched a new clinical trial to test a vaccine to protect against “devastating” Marburg virus. This is the first-in-human trial of the ChAdOx1 Marburg vaccine, which has been developed and manufactured by researchers at the University of Oxford.

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Virus Vaccine Trials Clinical Trials 148

Drug Discovery World

APRIL 30, 2024

They aim to tackle barriers that ordinarily prevent new tests and treatments reaching patients with rare diseases and speed up the delivery of rare disease treatment trials. However, rare disease research can be fragmented. The £12 ($15) million centre will develop a UK ‘four nations’ approach to deliver trials of new treatments.

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Drug Discovery World

JULY 5, 2024

The Division of Clinical Neuroscience at Oslo University Hospital (OUS) and the Swedish drug development company TikoMed have signed a research collaboration agreement focused on amyotrophic lateral sclerosis (ALS).

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Drug Discovery World

NOVEMBER 24, 2023

The pivotal proof-of-concept testing clears the way to progress the Clamp2 technology in a range of research programmes. Project leader, Associate Professor Keith Chappell, said the preliminary clinical trial results were an ‘exciting reward’ for the team’s continued dedication and the community’s widespread support for the project. “We

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Drug Discovery World

AUGUST 27, 2024

Skye Bioscience has started screening patients for a Phase II clinical trial (CBeyond) of its novel peripheral CB1 inhibitor, nimacimab, a negative allosteric modulating antibody. Assessing psychiatric effects of CB1 inhibition The clinical trial will enrol 120 patients across four treatment groups.

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Drug Discovery World

JUNE 24, 2024

Scientists at the Brain Tumour Research Centre of Excellence at the University of Plymouth are conducting a clinical trial to see whether using anti-retroviral medications, ritonavir and lopinavir, could help people with Neurofibromatosis 2 (NF2).

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Clinical Trials Trials Drugs DNA 148

Drug Discovery World

JULY 12, 2024

Covid-19 is no longer in the top five most studied indications, replaced by type 2 diabetes, according to Phesi’s mid-year analysis of clinical trials. The analysis of 66,935 clinical trials reveals that the top five most studied diseases are now breast cancer, solid tumours, stroke, prostate cancer and type 2 diabetes.

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Research Clinical Trials Clinical Development Trials 148

Antidote

MARCH 12, 2024

For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.

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Trials Research Clinical Research 119

Drug Discovery World

AUGUST 19, 2024

CV6 Therapeutics has initiated patient dosing in Phase Ia clinical trial evaluating its investigational first-in-class, specific dUTPase inhibitor CV6-168 + infusional 5-fluorouracil (5-FU).

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Drug Discovery World

MAY 14, 2024

The study examined the motivators and deterrents of clinical trial participation among ethnic minorities and outlined strategies sponsors can utilise to minimise deterrents and promote diversity in their research. “Diversity in clinical trials isn’t a nice to have, it’s a medical necessity. Read the full paper.

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Trials Clinical Trials Clinical Research Research 130

Drug Discovery World

MAY 17, 2024

Deepika Khedekar , Associate Centralized Clinical Trial Lead at IQVIA Inc, looks at the challenges of utilising artificial intelligence (AI) in oncology clinical research. MIT research 4 tells us a hard truth: about 95% of these trials fall short, leaving behind a trail of broken hopes for cancer patients each year.

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Trials Clinical Trials Treatment Research 148

Drug Discovery World

DECEMBER 19, 2023

The first patient has been dosed with an engineered B cell investigational therapy in a Phase I trial in Mucopolysaccharidosis type I (MPS I). The post World’s first engineered B cell therapy enters human trials appeared first on Drug Discovery World (DDW).

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Drug Discovery World

SEPTEMBER 3, 2024

The therapy is now approved by both the FDA and China Center for Drug Evaluation (CDE) to enter clinical trials in both countries for advanced solid tumour patients. Diana Spencer, Senior Digital Content Editor, DDW The post FDA clears genetically engineered TIL therapy for solid tumour trials appeared first on Drug Discovery World (DDW).

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Engineering Therapies FDA Trials 148

Drug Discovery World

NOVEMBER 8, 2023

Deepika Khedekar , Associate Centralized Clinical Lead at IQVIA, explains how artificial intelligence could make clinical trials more accurate, accessible and standardised. Tapping into the capabilities of AI One reason AI may accelerate clinical trials is its ability to rapidly process and analyse vast amounts of data.

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Clinical Trials Trials Disease Medical Schools 183

Antidote

JANUARY 18, 2024

Antidote’s mission is to connect patients with medical research so medical breakthroughs can take place. We provide our clinical trial matching technology, Antidote Match, at no cost to these organizations, to help patients and caregivers discover new research opportunities and connect to clinical trials quickly and easily.

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Clinical Trials Trials Research 105

Drug Discovery World

JULY 30, 2024

A new partnership between NHS Scotland, AstraZeneca and the Universities of Dundee and Glasgow hopes to accelerate research into treating chronic kidney disease. As we navigate the complex issue of chronic kidney disease, our commitment to patient-centred research remains unwavering.

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Disease Research Government Clinical Trials 130

Drug Discovery World

JUNE 25, 2024

A new study demonstrates that AI-powered digital twin solutions can potentially replace the standard-of-care (SOC) control arm of a clinical trial. We have demonstrated that digital twins offer real potential to replace standard-of-care comparator arms to streamline the implementation of clinical trials and dramatically reduce patient burden.”

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Clinical Trials Trials Hospitals Clinical Research 148

Drug Discovery World

MAY 14, 2024

In the clinic, I am always involved in clinical trials, both industry-initiated and investigator-initiated. The neoadjuvant concept has become an ideal platform for both drug discovery and translational research. MT: What industry-wide drug discovery breakthrough has most impacted your research?

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Drug Discovery World

FEBRUARY 8, 2023

A diversity study has shown that clinical trials should use real world diseases epidemiology data, rather than US Census Bureau race and ethnicity data, to ensure enrolment reflects the populations affected by different diseases. It also showed that GSK trial enrolment for each condition differed by race and ethnicity.

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Drug Discovery World

MAY 8, 2024

Calliditas Therapeutics has announced data from the proof-of-concept Phase II trial evaluating setanaxib, its lead NOX enzyme inhibitor, in combination with pembrolizumab, in patients with squamous cell carcinoma of the head and neck (SCCHN).

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ProRelix Research

MAY 31, 2023

Introduction: Clinical trials are a crucial component of the pharmaceutical and medical research industry, aimed at evaluating the safety and effectiveness of new drugs, treatments, or medical devices before they […] The post Successful Clinical Trial With ProRelix Research: Phase 1, 2, 3 & 4 Clinical Trial Services at … appeared (..)

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Clinical Trials Trials Research Pharmaceuticals 98

Drug Discovery World

JULY 10, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. In the first article, DDW Editor Reece Armstrong looks into recent research which may explain why cancers can become more aggressive.

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Research Clinical Trials Trials Drugs 148

Drug Discovery World

MARCH 10, 2023

Cancer Research UK and UCB have agreed a clinical development collaboration to advance two of UCB’s investigational oncology antibody candidates through clinical trials. If successful in clinical trials the investigational candidates may have the potential to offer cancer patients access to new targeted treatment options.

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SCIENMAG: Medicine & Health

FEBRUARY 2, 2024

Clinical trials and medical research have been historically lacking in diversity among all groups. Credit: Hackensack Meridian Health Clinical trials and medical research have been historically lacking in diversity among all groups.

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Clinical Trials Trials Research 77

Drug Discovery World

JUNE 25, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers three articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. and Choosing the right site solution for clinical trials.

Clinical Trials 130

Clinical Trials Trials Drugs Pharmaceuticals 130

Drug Discovery World

AUGUST 24, 2022

The trial will see participants receive either a 14-day course of 600 mg tecovirimat twice daily or a matched placebo treatment. As a community-based trial, participants will take the treatment or placebo in their own homes. The trial looks to include at least 500 participants in the UK. .

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Drug Discovery World

MARCH 23, 2023

A series of new measures will be introduced by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) to make it faster and easier to gain approval and run clinical trials in the UK. For example, the regulatory and ethics reviews of clinical trial applications will be integrated.

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Drug Discovery World

AUGUST 9, 2024

The first patient has been dosed in a Phase I clinical trial of AGX101, a novel TM4SF1-directed antibody-drug conjugate being developed for the treatment of solid cancers. We look forward to evaluating AGX101 in this trial.”

Trials 148

Trials Pharmacokinetics Drugs Clinical Trials 148

Drug Discovery World

JULY 10, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. In the first article, DDW Editor Reece Armstrong looks into recent research which may explain why cancers can become more aggressive.

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Research Clinical Trials Trials Drugs 130

Drug Discovery World

JULY 5, 2024

AviadoBio has launched its Phase I/II ASPIRE-FTD clinical trial at the Ohio State University in the US. There is an urgent need for collaboration between researchers, clinicians, patients, advocates, and families to courageously explore new approaches for FTD, including innovative and targeted delivery approaches.”

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Therapies Trials Clinical Trials Clinical Development 148

Drug Discovery World

JUNE 3, 2024

Thousands of cancer patients in England are set to gain fast-tracked access to trials of mRNA personalised cancer vaccines following the launch of an NHS trial ‘matchmaking’ service to help find new life-saving treatments.

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Drug Discovery World

JANUARY 11, 2024

VRG50635 is a small molecule PIKfyve inhibitor and is reportedly one of the first drugs to enter clinical trials that was entirely discovered and developed using an AI-enabled platform. ” The post AI-discovered ALS drug trial uses unique remote monitoring appeared first on Drug Discovery World (DDW).

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Drug Trials Trials Small Molecule Clinical Trials 246

Drug Discovery World

MAY 30, 2024

The Michael J Fox Foundation (MJFF) has awarded a grant of more than SEK 20 million ($2 million) to conduct this first Phase I clinical trial of IRL757. IRLAB has also recently announced a collaboration with McQuade Center for Strategic Research and Development (MSRD), part of Otsuka, to develop IRL757 further.

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Drug Discovery World

FEBRUARY 28, 2024

Lu Rahman selects some of the year’s interesting and noteworthy advances in cancer research drug discovery and development. In the UK, according to Cancer Research UK, around 167,000 people die from cancer in the UK each year. Research into new drugs and therapeutics is on-going and is helping drive mortality rates down.

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Drug Discovery World

MAY 8, 2024

Fiona Maini , Senior Director Global Compliance & Strategy, at Medidata looks at the rise of artificial intelligence (AI) and machine learning (ML) within life sciences and the applications for the technology in clinical trials.

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Clinical Trials Trials Regulations Compliance 163

Antidote

MAY 18, 2023

Clinical Trials Day takes place on May 20 each year, and is a day to celebrate the thousands of medical research volunteers who participate in trials for a wide range of conditions. It's also a day to raise awareness of the fact that even more volunteers are needed to push medical research forward.

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